Comparing off-pump lung transplantation to venoarterial ECMO lung transplantation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to compare two techniques for bilateral lung transplantation: off-pump lung transplantation and venoarterial ECMO (VA ECMO). The research focuses on evaluating which method results in lower rates of primary graft dysfunction (PGD) post-surgery. By utilizing a prospective multicenter randomized approach, the study seeks to address conflicting results from previous retrospective analyses regarding the effectiveness of these techniques. The trial is part of the Extracorporeal Life Support Registry in Lung Transplantation, which has previously highlighted the impact of intraoperative support on PGD rates.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Bilateral Lung Transplantation (LTx) recipients.
* Mean pulmonary artery pressure \< or = 35 mmHg.
* Eligible for off-pump or VA ECMO based on the judgement of the attending surgeon.

Exclusion Criteria:

* Single lung transplant
* Multiorgan transplant.
* Donor after cardiac death (DCD).
* Re-transplant.
* Intention to use prophylactic post-operative ECMO.
* Previous major lung surgery. Video-assisted thoracoscopic surgery (VATS) and wedge resection are not an exclusion criterion.
* Previous pleurodesis.
* Preoperative ECMO and/or mechanical ventilation.

Where it's running

• Cedar's Sinai
  Los Angeles, California, United States Recruiting
• University Of Louisville
  Louisville, Kentucky, United States Recruiting
• Johns Hopkins
  Baltimore, Maryland, United States Recruiting
• Mayo Clinic Rochester
  Rochester, Minnesota, United States Recruiting
• Ohio State University
  Columbus, Ohio, United States Recruiting
• Temple University
  Philadelphia, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Mauricio Villavicencio, MD, MBA — Mayo Clinic
• Study coordinator: Mauricio Villavicencio, MD, MBA
• Email: villavicencio.mauricio@mayo.edu
• Phone: 507-2557068

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.