Registry for lung transplant outcomes using the OCS Lung System
Official title: US National OCS Lung Thoracic Organ Perfusion (TOP) Registry
Run by TransMedics · NCT06513091 · Data updated 2026-11-12
This study is tracking how well lung transplants work for patients who received donor lungs preserved with a new device called the OCS Lung System to see if it improves outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 10000 (estimated) |
| Sponsor | TransMedics Industry-sponsored |
| Locations | 7 sites (Phoenix, Arizona and 6 other locations) |
| Status | Recruiting |
| Started | January 23, 2025 |
| Main results expected | November 2034 |
| Study ends | November 2039 |
| Registry record updated | September 3, 2025 |
| Trial ID | NCT06513091 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this registry are all individuals who have undergone lung transplantation.
✕Probably not a fit
Patients who have not received a lung transplant will not benefit from this registry.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This registry aims to collect both short and long-term clinical outcome data from lung transplant recipients who have received donor lungs preserved and assessed using the OCS Lung System. The study will document the performance of the OCS device in real-world settings following its FDA approval in the United States. By gathering comprehensive data, the registry seeks to enhance understanding of lung transplant outcomes and the effectiveness of the OCS technology.
Why it matters
Potential benefit: If successful, this registry could improve lung transplant outcomes and inform best practices for the use of the OCS Lung System.
How similar studies have gone: While this registry approach is not novel, it builds on previous successful registries that have documented transplant outcomes.
Who can join: the full rules
Show full inclusion / exclusion criteria
All lung transplant recipients
Where it's running
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St. Joseph's Hospital & Medical Center
Phoenix, Arizona, United States Recruiting -
Stanford University School of Medicine
Stanford, California, United States Recruiting -
University of Minnesota
Minneapolis, Minnesota, United States Recruiting -
Duke University
Durham, North Carolina, United States Recruiting -
Baylor Scott & White Research Institute
Dallas, Texas, United States Recruiting -
Baylor College of Medicine
Houston, Texas, United States Recruiting
Show 1 more location
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Medical College of Wisconsin
Milwaukee, Wisconsin, United States Recruiting
Study contacts
- Study coordinator: Julia Church
- Email: jdeane@transmedics.com
- Phone: 9782893546
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Research on improving outcomes for lung transplant donors and recipients
This study is trying to see how different donor and medical practices affect the health of lung transplant patients and donors, while also looking for blood markers that might predict complications after the surgery.
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Multidisciplinary non-drug program to improve quality of life after solid organ transplant
A multidisciplinary, non-drug program using acupuncture, remote physical rehab, and brain-health activities is being tested to see if it can improve quality of life for adults at least one year after heart, kidney, liver, or lung transplant.
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Multimodal prospective approach to understand acute and chronic lung transplant rejection
This project will see if blood tests, airway sampling, imaging, and genetic analyses can identify which adults who have had or are being evaluated for a lung transplant will develop antibody‑mediated rejection and later chronic graft dysfunction.
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Airway response to exercise after double lung transplant
This study will see if short (5-minute) versus longer (15-minute) constant-work exercise causes different airway narrowing and breathlessness in people who have had a double lung transplant.
-
Measuring breathing effort before and after removing the breathing tube
This will test a new electrical impedance method to measure breathing effort in adults on ventilators as they try breathing on their own and after the breathing tube is removed.
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Cryo nerve block to improve recovery after bilateral lung transplant
This pilot will test whether adding a cryo nerve block around the chest helps people with end-stage COPD recover better after a bilateral lung transplant.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.