Predictors of Lung Transplant Success and Costs
Official title: Clinical and Biological Factors Predicting Lung Transplant Textbook Outcomes (U01)
Funded at Duke University · NIH-11394471 · Data updated 2026-11-12
This study looks at what pre-transplant patient factors and biology predict a smooth recovery and lower costs after lung transplant.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | August 5, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $370,073 |
| NIH project number | 5U01HL163300-05 |
| Project ID | NIH-11394471 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older who are undergoing or being evaluated for lung transplantation at participating centers.
✕Less likely to help
Patients not undergoing lung transplantation or those without pretransplant data may not benefit from these findings.
What this research studies
If you or a loved one is waiting for a lung transplant, this project aims to identify which pretransplant clinical features and aging-related biological factors are linked to ideal, complication-free early recovery and lower health-care costs. The team will use data from several major lung transplant centers to define and compare outcomes that constitute a textbook-level recovery. By linking patient characteristics with early post-operative results and costs, the research hopes to spot targets for improving care before surgery. The work builds on prior definitions of textbook outcomes and seeks to understand variability across centers to guide personalized care.
Why it matters
Potential benefit: If successful, this work could help clinicians tailor pretransplant care to reduce complications and costs, potentially improving survival and value of transplantation for patients.
How similar studies have gone: Previous work shows that achieving textbook outcomes is linked to better survival and lower costs, but there is wide center-to-center variability which this study will address.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Snyder, Laurie D — Duke University
- Study coordinator: Snyder, Laurie D
Related research
Other NIH-funded projects on the same topics.
-
Exercise-based frailty program for people awaiting lung transplants
A tailored exercise and lifestyle program is being tested to reduce frailty and improve outcomes for people waiting for a lung transplant.
-
Understanding why a lung transplant sometimes fails early and how to tailor treatment
A study of people receiving lung transplants to find molecular differences that cause early graft failure and point to better, personalized therapies.
-
Targeting inflammation and alloimmunity in lung transplant recipients with clazakizumab
A study to see if blocking IL-6 with clazakizumab can improve survival and reduce rejection in people who have received a lung transplant.
-
Vaccination responses in lung transplant patients
This grant studies how people who have received lung transplants respond to COVID-19 vaccines and why their antibody responses may be limited.
-
The Post-Lung Transplant Aging in Immune Cells in Donor Lungs
This grant explores how aging donor lungs affect lung transplant outcomes by studying immune cells called alveolar macrophages.
-
Lung Transplant Network Data Center coordinating multicenter research
A national network is creating a shared data and biosample hub to support a large study of people who receive lung transplants.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.