Airway response to exercise after double lung transplant

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants who are at least three months after double lung transplantation will perform two constant-work exercise sessions at 60% of their peak oxygen uptake in random order, one lasting 5 minutes and one lasting 15 minutes. Ratings of perceived exertion will be recorded every 5 minutes during exercise and forced expiratory volume in 1 second (FEV1) will be measured before exercise, immediately after, and at 5, 10, 15, 20, and 30 minutes post-exercise to document airway response. The protocol excludes people with asthma, significant airflow limitation (FEV1 ≤50% predicted), recent infection or rejection within one month, or other exercise contraindications. The study is observational and compares the time course and magnitude of post-exercise airway changes and symptoms between the two exercise durations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Received double lung transplantation
2. ≥ 3 months post-transplant

Exclusion Criteria:

1. Diagnosis of asthma
2. Significant airflow limitation (≤50% FEV1 predicted)
3. Inability to cooperate with the required tests and measurements
4. Recent infection or rejection within 1 month
5. Exercise contraindication (e.g., recent heart attack or stroke within 3 months, uncontrolled hypertension, known aortic aneurysm, unstable cardiac ischemia, malignant arrhythmias)

Where it's running

• Chang Gung Memorial Hospital, Linkou Branch
  Taoyuan, Taiwan Recruiting

Study contacts

• Study coordinator: Mei-Chun Wan
• Email: alliewan@cgmh.org.tw
• Phone: +886-3-3281200

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.