Airway response to exercise after double lung transplant
Bronchial Response to Exercise After Double Lung Transplantation
This study will see if short (5-minute) versus longer (15-minute) constant-work exercise causes different airway narrowing and breathlessness in people who have had a double lung transplant.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 20 Years and up |
| Sex | All |
| Sponsor | Chang Gung Memorial Hospital Academic / other |
| Locations | 1 site (Taoyuan) |
| Trial ID | NCT07035743 on ClinicalTrials.gov |
What this trial studies
Participants who are at least three months after double lung transplantation will perform two constant-work exercise sessions at 60% of their peak oxygen uptake in random order, one lasting 5 minutes and one lasting 15 minutes. Ratings of perceived exertion will be recorded every 5 minutes during exercise and forced expiratory volume in 1 second (FEV1) will be measured before exercise, immediately after, and at 5, 10, 15, 20, and 30 minutes post-exercise to document airway response. The protocol excludes people with asthma, significant airflow limitation (FEV1 ≤50% predicted), recent infection or rejection within one month, or other exercise contraindications. The study is observational and compares the time course and magnitude of post-exercise airway changes and symptoms between the two exercise durations.
Who should consider this trial
Good fit: Ideal candidates are people at least three months after double lung transplantation who can exercise, do not have asthma, have adequate lung function above the exclusion threshold, and have no recent infection or rejection.
Not a fit: Patients with a diagnosis of asthma, severe airflow obstruction (FEV1 ≤50% predicted), recent infection or rejection within one month, or cardiac/exercise contraindications are unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, the findings could help tailor exercise prescriptions and monitoring to reduce breathlessness and improve safe rehabilitation for double lung transplant recipients.
How similar studies have performed: Exercise-induced airway narrowing has been documented in other populations, but direct randomized comparisons of short versus longer exercise durations in double lung transplant recipients are limited and relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Received double lung transplantation 2. ≥ 3 months post-transplant Exclusion Criteria: 1. Diagnosis of asthma 2. Significant airflow limitation (≤50% FEV1 predicted) 3. Inability to cooperate with the required tests and measurements 4. Recent infection or rejection within 1 month 5. Exercise contraindication (e.g., recent heart attack or stroke within 3 months, uncontrolled hypertension, known aortic aneurysm, unstable cardiac ischemia, malignant arrhythmias)
Where this trial is running
Taoyuan
- Chang Gung Memorial Hospital, Linkou Branch — Taoyuan, Taiwan (Recruiting)
Study contacts
- Study coordinator: Mei-Chun Wan
- Email: alliewan@cgmh.org.tw
- Phone: +886-3-3281200
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.