Improving lung transplant acceptance through cellular therapies
Project 2: The New Era of Cellular Therapies For Lung Transplant Tolerance
This study is looking for new ways to help people who have received lung transplants accept their new lungs without needing to take medication for the rest of their lives, by using safe methods to help their bodies recognize the transplant as part of themselves.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11035230 on NIH RePORTER |
What this research studies
This research investigates new methods to achieve long-term acceptance of lung transplants without the need for lifelong immunosuppression. It focuses on developing safe conditioning regimens to induce mixed chimerism, which can help the body accept the transplanted lung as its own. The study also aims to enhance the function of regulatory T cells, which play a crucial role in maintaining immune tolerance. By exploring these innovative approaches, the research seeks to improve outcomes for lung transplant recipients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are undergoing or have undergone lung transplantation and are at risk of allograft rejection.
Not a fit: Patients who are not candidates for lung transplantation or those with advanced lung disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to life-long acceptance of lung transplants, significantly reducing complications and improving quality of life for patients.
How similar studies have performed: Previous research has shown success in achieving transplant tolerance in kidney transplants, but this approach for lung transplants is still in the early stages and represents a novel area of investigation.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Kean, Leslie S — Massachusetts General Hospital
- Study coordinator: Kean, Leslie S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.