National coordination of lung transplant patient data and biosamples
Official title: Lung Transplant Consortium - Data Coordinating Center
Funded at Duke University · NIH-11382478 · Data updated 2026-11-12
This effort collects detailed health information and repeated blood and tissue samples from people who get lung transplants to help researchers learn what affects early and long-term outcomes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | August 5, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $129,600 |
| NIH project number | 3U24HL163122-04S1 |
| Project ID | NIH-11382478 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are people being evaluated for or who have received a lung transplant at one of the consortium's participating transplant centers.
✕Less likely to help
People without lung transplant disease, those not treated at participating centers, or those who decline to provide samples or data would not be able to participate or directly benefit from this project.
What this research studies
As a lung transplant patient or recipient, you would be part of a multisite effort that plans to enroll about 3,200 people across roughly 8 transplant centers and 24 clinical sites. The Duke Clinical Research Institute will run the data coordinating center while the University of Pennsylvania will manage the biorepository to store clinical data and serial biosamples. The project uses a single common protocol to gather standardized clinical information, outcomes, and repeat samples over time. The combined dataset and sample collection will create a resource for many future studies aimed at improving donor management, candidate selection, and recipient care.
Why it matters
Potential benefit: If successful, this resource could help identify causes of early complications and long-term problems after lung transplant and lead to better donor selection and patient care.
How similar studies have gone: Multicenter transplant registries and biobanks have previously helped find risk factors and biomarkers, so the overall approach is proven though this consortium's larger, standardized scope is newer.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Palmer, Scott M — Duke University
- Study coordinator: Palmer, Scott M
Related research
Other NIH-funded projects on the same topics.
-
Exercise-based frailty program for people awaiting lung transplants
A tailored exercise and lifestyle program is being tested to reduce frailty and improve outcomes for people waiting for a lung transplant.
-
Understanding why a lung transplant sometimes fails early and how to tailor treatment
A study of people receiving lung transplants to find molecular differences that cause early graft failure and point to better, personalized therapies.
-
Targeting inflammation and alloimmunity in lung transplant recipients with clazakizumab
A study to see if blocking IL-6 with clazakizumab can improve survival and reduce rejection in people who have received a lung transplant.
-
Vaccination responses in lung transplant patients
This grant studies how people who have received lung transplants respond to COVID-19 vaccines and why their antibody responses may be limited.
-
The Post-Lung Transplant Aging in Immune Cells in Donor Lungs
This grant explores how aging donor lungs affect lung transplant outcomes by studying immune cells called alveolar macrophages.
-
Predictors of Lung Transplant Success and Costs
This study looks at what pre-transplant patient factors and biology predict a smooth recovery and lower costs after lung transplant.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.