Multimodal prospective approach to understand acute and chronic lung transplant rejection

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, observational project recruiting adults who have undergone or are being evaluated for lung transplantation to the NIH Clinical Center. Participants will have clinic visits every 3–6 months for up to four years with blood draws, bronchoscopy with bronchoalveolar lavage, imaging, pulmonary function testing, and genetic/molecular profiling. The study will track donor-specific antibody (DSA) emergence and profile molecular changes that occur from DSA detection through acute antibody‑mediated rejection (AMR) and development of chronic lung allograft dysfunction (CLAD). Data aim to link clinical, imaging, and molecular signatures to timing and mechanisms of rejection.

Why it matters

Who can join: the full rules

* INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

1. Stated willingness to comply with study procedures and availability for the duration of the study.
2. Male or female, aged 18 - 75 years of age.
3. Have progressive lung disease or undergone or being evaluated for lung transplantation.
4. Ability of subjects to understand the informed consent document.

EXCLUSION CRITERIA:

An individual who meets any of the following criteria will be excluded from participation in this study:

1\. Pregnancy or lactation

Where it's running

• National Institutes of Health Clinical Center
  Bethesda, Maryland, United States Recruiting

Study contacts

• Principal investigator: Muhtadi H Alnababteh, M.D. — National Heart, Lung, and Blood Institute (NHLBI)
• Study coordinator: Andrew G Keel, C.R.N.P.
• Email: andrew.keel@nih.gov
• Phone: (301) 648-5674

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Muscle health before and after lung transplant in adults

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.