Vaccine responses in people with lung transplants
Vaccination responses in lung transplant recipients
This project looks at how well COVID-19 vaccines trigger immune protection in people who have had lung transplants.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11158660 on NIH RePORTER |
What this research studies
If you’ve had a lung transplant, doctors in this project will collect blood and other samples before and after you get vaccines and store them in a vaccine biobank. Researchers will run detailed immune tests—measuring antibodies, cellular responses, and system-wide signatures—to map how your immune system reacts while on transplant medications. The effort joins patients seen at Stanford, Inova-Fairfax, and Houston Methodist so teams can compare results across centers. The overall aim is to understand why some lung transplant recipients have weak vaccine responses and to identify ways to improve protection.
Who could benefit from this research
Good fit: People who have received a lung transplant and are followed at one of the participating transplant centers, especially those planning to receive or who recently received COVID-19 vaccination, are ideal candidates.
Not a fit: People without a lung transplant or those unable or unwilling to provide biological samples or travel to a participating center are unlikely to benefit directly from this project.
Why it matters
Potential benefit: Results could lead to better vaccine timing, dosing, or supportive treatments to increase protection for lung transplant patients.
How similar studies have performed: Recent reports show many solid-organ transplant recipients mount weak antibody responses to SARS‑CoV‑2 mRNA vaccines, and this project builds on those findings by adding deeper immune profiling and a centralized biobank.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Nicolls, Mark Robert — Stanford University
- Study coordinator: Nicolls, Mark Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.