Understanding Long-Term Outcomes After Lung Transplant
Official title: Long Term Follow up of the Lung Transplant Outcomes Group Cohort
Funded at University of Pennsylvania · NIH-11099858 · Data updated 2026-11-12
This project continues to follow patients who have received lung transplants to better understand their health over many years.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | June 15, 2019 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $1,445,795 |
| NIH project number | 5U01HL145435-07 |
| Project ID | NIH-11099858 on NIH RePORTER |
Who could benefit from this research
✓Could help
This project focuses on individuals who have previously undergone lung transplantation and were part of the original Lung Transplant Outcomes Group (LTOG) cohort.
✕Less likely to help
Patients who have not undergone a lung transplant or were not part of the initial LTOG cohort would not directly benefit from this specific follow-up project.
What this research studies
Lung transplantation can extend life for people with severe lung diseases, but many patients still face challenges like chronic lung allograft dysfunction (CLAD) and a shorter life expectancy. This project builds on a large, ongoing effort called the Lung Transplant Outcomes Group (LTOG), which has already gathered information from over 3000 transplant recipients. By continuing to collect clinical data and biological samples from these patients, we hope to uncover why some people do better than others after a lung transplant. Our goal is to gain crucial insights into the long-term health of lung transplant patients.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of long-term lung transplant outcomes, potentially guiding new strategies to improve patient health and quality of life.
How similar studies have gone: The Lung Transplant Outcomes Group (LTOG) has been a successful multi-center effort for over a decade, providing a rich resource for this continued follow-up.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Christie, Jason D — University of Pennsylvania
- Study coordinator: Christie, Jason D
Related research
Other NIH-funded projects on the same topics.
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Exercise-based frailty program for people awaiting lung transplants
A tailored exercise and lifestyle program is being tested to reduce frailty and improve outcomes for people waiting for a lung transplant.
-
Understanding why a lung transplant sometimes fails early and how to tailor treatment
A study of people receiving lung transplants to find molecular differences that cause early graft failure and point to better, personalized therapies.
-
Targeting inflammation and alloimmunity in lung transplant recipients with clazakizumab
A study to see if blocking IL-6 with clazakizumab can improve survival and reduce rejection in people who have received a lung transplant.
-
Vaccination responses in lung transplant patients
This grant studies how people who have received lung transplants respond to COVID-19 vaccines and why their antibody responses may be limited.
-
The Post-Lung Transplant Aging in Immune Cells in Donor Lungs
This grant explores how aging donor lungs affect lung transplant outcomes by studying immune cells called alveolar macrophages.
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Predictors of Lung Transplant Success and Costs
This study looks at what pre-transplant patient factors and biology predict a smooth recovery and lower costs after lung transplant.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.