Multidisciplinary non-drug program to improve quality of life after solid organ transplant

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center study tests a non-pharmacological approach for solid organ transplant recipients. The program combines acupuncture, telerehabilitation-based physical therapy, and psychological/brain-health support to see if health-related quality of life and well-being can be improved. Eligibility includes adults 25–65 who are at least one year post-transplant with certain quality-of-life indicators and no contraindications to exercise. The trial will provide preliminary estimates of impact and assess feasibility of implementing this approach in clinical practice.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 25 years and ≤ 65 years;
* Solid organ transplantation (liver, kidney, heart, or lung) performed at least 1 year prior to enrollment, with good graft functional recovery according to organ-specific criteria;
* Ability to understand and independently complete questionnaires;
* Ability to provide written informed consent;
* Absence of clinical contraindications to therapeutic exercise;
* Adequate cognitive status;
* SF-36 score \< 50 or Distress Thermometer (DT) score ≥ 4 and Pittsburgh Sleep Quality Index (PSQI) score ≥ 5.

Exclusion Criteria:

* Diagnosis of severe cognitive impairment, acute psychiatric illness, or significant hearing or visual disability;
* Severe ongoing complications or comorbidities that would prevent participation in the physiotherapy program;
* Unstable immunosuppressive therapy and/or evidence of ongoing graft rejection;
* Diagnosis of active malignancy;
* Pregnancy.

Where it's running

• IRCCS ISMETT - Istituto Mediterraneo per i Trapianti e le Terapie ad Alta Specializzazione
  Palermo, Palermo, Italy Recruiting

Study contacts

• Study coordinator: Giada Pietrosi
• Email: gpietrosi@ismett.edu
• Phone: +39 0912192111

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Multimodal prospective approach to understand acute and chronic lung transplant rejection

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• Airway response to exercise after double lung transplant

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• Measuring breathing effort before and after removing the breathing tube

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• Cryo nerve block to improve recovery after bilateral lung transplant

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  Recruiting University Hospital, Gasthuisberg · Leuven, Vlaams-Brabant · NCT06959056

• Identifying noninvasive markers of heart transplant rejection in patients with congenital heart disease

  This study is testing a new blood test to see if it can help detect heart transplant rejection in patients with congenital heart disease without needing a more invasive procedure.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna · NCT06784440

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.