Exercise program to reduce frailty in people awaiting lung transplant
XFIT: An Exercise-based Frailty Intervention in Lung Transplant Candidates
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11193900
A tailored exercise and lifestyle program to help people who are frail while waiting for a lung transplant get stronger and more active.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11193900 on ClinicalTrials.gov |
What this research studies
You would be offered a personalized exercise and lifestyle program adapted from geriatric and pulmonary rehabilitation approaches to address weakness, muscle loss, inflammation, and low activity. The team at UCSF working with geriatrics, pulmonary rehab, and exercise physiologists would tailor supervised sessions and home-based exercises to your needs. Researchers will collect measures like strength, body composition, activity levels, and blood markers before and after the program to track change. The intervention is designed specifically for people listed for lung transplant to try to improve function before and after surgery.
Who could benefit from this research
Good fit: Ideal candidates are adults who are listed for lung transplantation and show signs of physical frailty, low strength, or low activity.
Not a fit: People who are not on a lung transplant list, are not physically frail, or who cannot safely participate in exercise because of unstable medical conditions may not benefit from this program.
Why it matters
Potential benefit: If successful, this program could improve strength and fitness, reduce complications around transplant, and increase chances of surviving and recovering after transplant.
How similar studies have performed: Exercise and lifestyle programs have improved frailty and physical function in older adults, but applying these interventions specifically to lung transplant candidates is a novel approach that has not yet been proven.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SINGER, JONATHAN PAUL — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: SINGER, JONATHAN PAUL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.