Understanding how stress responses affect lung transplant outcomes
Pathological activation of integrated stress response as a driver of Chronic allograft dysfunction after lung transplant
This study is looking at how stress in the body affects lung transplants and aims to find ways to improve the health of transplanted lungs by understanding how certain cells behave, so it’s for people who have had a lung transplant and want to ensure their new lungs stay healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11024748 on NIH RePORTER |
What this research studies
This research investigates the role of the integrated stress response in the development of chronic allograft dysfunction following lung transplantation. It aims to uncover the molecular mechanisms linking early graft dysfunction to long-term complications like lung fibrosis. By studying the behavior of specific immune cells and epithelial cells in the lungs, the research seeks to identify potential targets for improving lung transplant outcomes. Patients may be monitored for changes in their lung function and overall health as part of this investigation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have undergone lung transplantation or are awaiting a lung transplant.
Not a fit: Patients with lung transplants who are not experiencing any complications or those with other unrelated lung conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing chronic lung transplant complications, enhancing patient survival and quality of life.
How similar studies have performed: Previous research has indicated that understanding the immune response and stress mechanisms in lung transplants can lead to significant improvements in patient outcomes, suggesting a promising avenue for this investigation.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Kurihara, Chitaru — Northwestern University at Chicago
- Study coordinator: Kurihara, Chitaru
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.