Clinical trial Recruiting at 14 sites Observational Ages 18 and up

Evaluating the impact of MR-guided radiation therapy on cancer treatment outcomes

Official title: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

Run by UMC Utrecht · NCT04075305 · Data updated 2026-11-12

This study is testing how using a special type of radiation therapy with real-time imaging can improve treatment results and quality of life for adults with cancer.

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Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment8000 (estimated)
SponsorUMC Utrecht
Academic / other
Drugs / interventionsradiation
Locations18 sites (Pittsburgh, Pennsylvania and 17 other locations)
StatusRecruiting
StartedFebruary 1, 2019
Main results expectedFebruary 1, 2030
Study endsAugust 1, 2030
Registry record updatedMarch 5, 2026
Trial IDNCT04075305 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are cancer patients aged 18 and older who are scheduled for treatment or imaging on an MR-Linac machine.

Probably not a fit

Patients with MRI contraindications, such as those who are pregnant or have incompatible metal implants, may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The MOMENTUM study is an international registry that collects data on patients undergoing radiation therapy using the MR-Linac technology. This observational cohort study aims to enhance the implementation of MR-guided radiation therapy, which allows for real-time imaging and precision treatment. By gathering technical and clinical data, the study seeks to optimize treatment outcomes, minimize side effects, and improve overall patient survival and quality of life. Participants include cancer patients aged 18 and older who are receiving treatment or imaging on the MR-Linac machine.

Why it matters

Potential benefit: If successful, this study could lead to improved survival rates and reduced side effects for cancer patients undergoing radiation therapy.

How similar studies have gone: Other studies have shown promise with MR-guided radiation therapy, indicating potential for success in this innovative approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patient is to undergo or has completed imaging or treatment procedures on an MR-Linac;
* Patient provides written, informed consent;
* Patient is 18 years old or older.

Exclusion Criteria:

* MRI exclusion criteria, including
* MRI contraindications as per usual clinical care, such as (possible) pregnancy; claustrophobia and metal or electronic implants not compatible with MRI.

Where it's running

  • Allegheny Health Network
    Pittsburgh, Pennsylvania, United States
    Recruiting
  • Md Anderson Cancer Center
    Houston, Texas, United States
    Recruiting
  • Medical College of Wisconsin
    Milwaukee, Wisconsin, United States
    Recruiting
  • Sunnybrook Health Sciences Centre/Odette Cancer Centre
    Toronto, Ontario, Canada
    Recruiting
  • University Health Network - Princess Margaret Cancer Center
    Toronto, Canada
    Recruiting
  • Odense Universitetshospital
    Odense, Funen, Denmark
    Recruiting
Show 12 more locations
  • Universitätsklinikum Tübingen
    Tübingen, Germany
    Recruiting
  • IRCCS Ospedale Sacro Cuore Don Calabria
    Negrar, Italy
    Recruiting
  • Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital
    Amsterdam, Netherlands
    Recruiting
  • Radiotherapiegroep
    Deventer, Netherlands
    Recruiting
  • Radboud UMC
    Nijmegen, Netherlands
    Recruiting
  • University Medical Center Utrecht
    Utrecht, Netherlands
    Recruiting
  • The Royal Marsden and The Institute of Cancer Research National Institute for Health Research Biomedical Research Centre
    London, United Kingdom
    Recruiting
  • The Christie National Health Service Foundation Trust
    Manchester, United Kingdom
    Recruiting
  • Austin Health - Olivia Newton-John Cancer Wellness and Research Centre
    Melbourne, Australia
    Not yet recruiting
  • Insitut Jules Bordet
    Brussels, Belgium
    Not yet recruiting
  • Università degli Studi di Brescia
    Brescia, Italy
    Not yet recruiting
  • Radiotherapeutisch Instituut Friesland (RIF)
    Leeuwarden, Netherlands
    Not yet recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.