Evaluating the impact of MR-guided radiation therapy on cancer treatment outcomes
Official title: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
Run by UMC Utrecht · NCT04075305 · Data updated 2026-11-12
This study is testing how using a special type of radiation therapy with real-time imaging can improve treatment results and quality of life for adults with cancer.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 8000 (estimated) |
| Sponsor | UMC Utrecht Academic / other |
| Drugs / interventions | radiation |
| Locations | 18 sites (Pittsburgh, Pennsylvania and 17 other locations) |
| Status | Recruiting |
| Started | February 1, 2019 |
| Main results expected | February 1, 2030 |
| Study ends | August 1, 2030 |
| Registry record updated | March 5, 2026 |
| Trial ID | NCT04075305 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are cancer patients aged 18 and older who are scheduled for treatment or imaging on an MR-Linac machine.
✕Probably not a fit
Patients with MRI contraindications, such as those who are pregnant or have incompatible metal implants, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The MOMENTUM study is an international registry that collects data on patients undergoing radiation therapy using the MR-Linac technology. This observational cohort study aims to enhance the implementation of MR-guided radiation therapy, which allows for real-time imaging and precision treatment. By gathering technical and clinical data, the study seeks to optimize treatment outcomes, minimize side effects, and improve overall patient survival and quality of life. Participants include cancer patients aged 18 and older who are receiving treatment or imaging on the MR-Linac machine.
Why it matters
Potential benefit: If successful, this study could lead to improved survival rates and reduced side effects for cancer patients undergoing radiation therapy.
How similar studies have gone: Other studies have shown promise with MR-guided radiation therapy, indicating potential for success in this innovative approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient is to undergo or has completed imaging or treatment procedures on an MR-Linac; * Patient provides written, informed consent; * Patient is 18 years old or older. Exclusion Criteria: * MRI exclusion criteria, including * MRI contraindications as per usual clinical care, such as (possible) pregnancy; claustrophobia and metal or electronic implants not compatible with MRI.
Where it's running
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Allegheny Health Network
Pittsburgh, Pennsylvania, United States Recruiting -
Md Anderson Cancer Center
Houston, Texas, United States Recruiting -
Medical College of Wisconsin
Milwaukee, Wisconsin, United States Recruiting -
Sunnybrook Health Sciences Centre/Odette Cancer Centre
Toronto, Ontario, Canada Recruiting -
University Health Network - Princess Margaret Cancer Center
Toronto, Canada Recruiting -
Odense Universitetshospital
Odense, Funen, Denmark Recruiting
Show 12 more locations
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Universitätsklinikum Tübingen
Tübingen, Germany Recruiting -
IRCCS Ospedale Sacro Cuore Don Calabria
Negrar, Italy Recruiting -
Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital
Amsterdam, Netherlands Recruiting -
Radiotherapiegroep
Deventer, Netherlands Recruiting -
Radboud UMC
Nijmegen, Netherlands Recruiting -
University Medical Center Utrecht
Utrecht, Netherlands Recruiting -
The Royal Marsden and The Institute of Cancer Research National Institute for Health Research Biomedical Research Centre
London, United Kingdom Recruiting -
The Christie National Health Service Foundation Trust
Manchester, United Kingdom Recruiting -
Austin Health - Olivia Newton-John Cancer Wellness and Research Centre
Melbourne, Australia Not yet recruiting -
Insitut Jules Bordet
Brussels, Belgium Not yet recruiting -
Università degli Studi di Brescia
Brescia, Italy Not yet recruiting -
Radiotherapeutisch Instituut Friesland (RIF)
Leeuwarden, Netherlands Not yet recruiting
Study contacts
- Principal investigator: Helena M Verkooijen, Prof, Dr — Universitair Medical Centre Utrecht
- Study coordinator: Tessa Leer
- Email: T.Leer@umcutrecht.nl
- Phone: T +31 (0)88 75 63707
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.