Clinical trial Recruiting at 30 sites Observational Ages 18 and up

DRAGON: International registry for patients who had combined portal and hepatic vein embolization before liver surgery

Official title: DRAGON Registry - International Multicenter Registry and Medical Image Bank for Patients With Primarily Unresectable Liver Cancer or Liver Metastases That Underwent Combined Portal and Hepatic Vein Embolization (PVE/HVE) to Increase Future Liver Remnant Before Resection.

Run by Maastricht University Medical Center · NCT07717437 · Data updated 2026-11-12

This registry collects data on patients who had PVE/HVE before liver resection to see if it helps liver regeneration and what factors relate to outcomes.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment350 (estimated)
SponsorMaastricht University Medical Center
Academic / other
Locations31 sites (Chicago, Illinois and 30 other locations)
StatusRecruiting
StartedMarch 16, 2021
Main results expectedNovember 30, 2027
Study endsNovember 30, 2032
Registry record updatedJuly 21, 2026
Trial IDNCT07717437 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults 18 years or older with liver cancer or liver metastases who have undergone PVE/HVE or related techniques prior to planned liver resection.

Probably not a fit

Patients who did not receive PVE/HVE or who undergo other treatment pathways without this technique may not experience the findings' implications.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The DRAGON Registry is an international, multicenter observational database that retrospectively and prospectively collects clinical and imaging data from patients who underwent combined portal and hepatic vein embolization prior to liver surgery. It aims to identify associations between baseline characteristics, imaging findings, and safety with post-procedure outcomes. The study does not assign any treatment; instead it observes real-world use of PVE/HVE and tracks complications, liver regeneration, and subsequent surgical results. Data are gathered from participating centers to help better understand which patients may benefit from this approach and how it influences future liver remnant and resection planning.

Why it matters

Potential benefit: If successful, the registry could clarify which patients are most likely to benefit from combined PVE/HVE and improve decision-making for liver cancer and metastasis patients.

How similar studies have gone: Prior studies on portal and hepatic vein embolization have shown promise, but this registry collects broader observational data to validate and extend those findings.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients who have undergone PVE/HVE or technical variations on this procedure
* 18 Years and older
* Men and women

Where it's running

  • Rush University Medical Center
    Chicago, Illinois, United States
    Recruiting
  • Mayo Clinic
    Rochester, Minnesota, United States
    Recruiting
  • Cleveland Clinic
    Cleveland, Ohio, United States
    Recruiting
  • Monash Medical Centre
    Clayton, Victoria, Australia
    Recruiting
  • MedUni Wien
    Vienna, State of Vienna, Austria
    Recruiting
  • Social Center South (Klinik Favoriten)
    Vienna, State of Vienna, Austria
    Recruiting
Show 25 more locations
  • UZ Antwerpen
    Edegem, Antwerpen, Belgium
    Recruiting
  • Erasmus Hospital
    Anderlecht, Brussels Capital, Belgium
    Recruiting
  • CHU de Liège
    Liège, Liège, Belgium
    Recruiting
  • UZ Gent
    Ghent, Oost-Vlaanderen, Belgium
    Recruiting
  • Juravinski Hospital and Cancer Centre
    Hamilton, Ontario, Canada
    Recruiting
  • The Ottawa Hospital
    Ottawa, Ontario, Canada
    Recruiting
  • McGill University Health Centre
    Montreal, Quebec, Canada
    Recruiting
  • University Hospital Aachen (Uniklinik RWTH Aachen)
    Aachen, North Rhine-Westphalia, Germany
    Recruiting
  • Klinikum Saarbrücken
    Saarbrücken, Saarland, Germany
    Recruiting
  • Universitätsklinikum Halle
    Halle, Saxony-Anhalt, Germany
    Recruiting
  • Mumc+
    Maastricht, Limburg, Netherlands
    Recruiting
  • Amsterdam UMC
    Amsterdam, North Holland, Netherlands
    Recruiting
  • Universitair Medisch Centrum Groningen
    Groningen, Provincie Groningen, Netherlands
    Recruiting
  • Leids Universitair Medisch Centrum
    Leiden, South Holland, Netherlands
    Recruiting
  • Auckland City Hospital
    Grafton, Auckland, New Zealand
    Recruiting
  • Oslo University Hospital
    Oslo, Oslo, Norway
    Recruiting
  • Hospital Universitari Germans Trias i Pujol
    Badalona, Barcelona, Spain
    Recruiting
  • Vall d'Hebron University Hospital
    Barcelona, Barcelona, Spain
    Recruiting
  • Karolinska University Hospital
    Stockholm, Stockholm County, Sweden
    Recruiting
  • University Hospital Linköping
    Linköping, Östergötland County, Sweden
    Recruiting
  • Klinik Hirslanden
    Zurich, Canton of Zurich, Switzerland
    Recruiting
  • Aintree University Hospital
    Liverpool, Merseyside, United Kingdom
    Recruiting
  • Newcastle upon Tyne Hospitals
    Newcastle upon Tyne, North East England, United Kingdom
    Recruiting
  • Queen Elizabeth Hospital
    Birmingham, West Midlands, United Kingdom
    Recruiting
  • Erasmus MC
    Rotterdam, South Holland, Netherlands
    Not yet recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.