DRAGON: International registry for patients who had combined portal and hepatic vein embolization before liver surgery
Official title: DRAGON Registry - International Multicenter Registry and Medical Image Bank for Patients With Primarily Unresectable Liver Cancer or Liver Metastases That Underwent Combined Portal and Hepatic Vein Embolization (PVE/HVE) to Increase Future Liver Remnant Before Resection.
Run by Maastricht University Medical Center · NCT07717437 · Data updated 2026-11-12
This registry collects data on patients who had PVE/HVE before liver resection to see if it helps liver regeneration and what factors relate to outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 350 (estimated) |
| Sponsor | Maastricht University Medical Center Academic / other |
| Locations | 31 sites (Chicago, Illinois and 30 other locations) |
| Status | Recruiting |
| Started | March 16, 2021 |
| Main results expected | November 30, 2027 |
| Study ends | November 30, 2032 |
| Registry record updated | July 21, 2026 |
| Trial ID | NCT07717437 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 years or older with liver cancer or liver metastases who have undergone PVE/HVE or related techniques prior to planned liver resection.
✕Probably not a fit
Patients who did not receive PVE/HVE or who undergo other treatment pathways without this technique may not experience the findings' implications.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The DRAGON Registry is an international, multicenter observational database that retrospectively and prospectively collects clinical and imaging data from patients who underwent combined portal and hepatic vein embolization prior to liver surgery. It aims to identify associations between baseline characteristics, imaging findings, and safety with post-procedure outcomes. The study does not assign any treatment; instead it observes real-world use of PVE/HVE and tracks complications, liver regeneration, and subsequent surgical results. Data are gathered from participating centers to help better understand which patients may benefit from this approach and how it influences future liver remnant and resection planning.
Why it matters
Potential benefit: If successful, the registry could clarify which patients are most likely to benefit from combined PVE/HVE and improve decision-making for liver cancer and metastasis patients.
How similar studies have gone: Prior studies on portal and hepatic vein embolization have shown promise, but this registry collects broader observational data to validate and extend those findings.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who have undergone PVE/HVE or technical variations on this procedure * 18 Years and older * Men and women
Where it's running
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Rush University Medical Center
Chicago, Illinois, United States Recruiting -
Mayo Clinic
Rochester, Minnesota, United States Recruiting -
Cleveland Clinic
Cleveland, Ohio, United States Recruiting -
Monash Medical Centre
Clayton, Victoria, Australia Recruiting -
MedUni Wien
Vienna, State of Vienna, Austria Recruiting -
Social Center South (Klinik Favoriten)
Vienna, State of Vienna, Austria Recruiting
Show 25 more locations
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UZ Antwerpen
Edegem, Antwerpen, Belgium Recruiting -
Erasmus Hospital
Anderlecht, Brussels Capital, Belgium Recruiting -
CHU de Liège
Liège, Liège, Belgium Recruiting -
UZ Gent
Ghent, Oost-Vlaanderen, Belgium Recruiting -
Juravinski Hospital and Cancer Centre
Hamilton, Ontario, Canada Recruiting -
The Ottawa Hospital
Ottawa, Ontario, Canada Recruiting -
McGill University Health Centre
Montreal, Quebec, Canada Recruiting -
University Hospital Aachen (Uniklinik RWTH Aachen)
Aachen, North Rhine-Westphalia, Germany Recruiting -
Klinikum Saarbrücken
Saarbrücken, Saarland, Germany Recruiting -
Universitätsklinikum Halle
Halle, Saxony-Anhalt, Germany Recruiting -
Mumc+
Maastricht, Limburg, Netherlands Recruiting -
Amsterdam UMC
Amsterdam, North Holland, Netherlands Recruiting -
Universitair Medisch Centrum Groningen
Groningen, Provincie Groningen, Netherlands Recruiting -
Leids Universitair Medisch Centrum
Leiden, South Holland, Netherlands Recruiting -
Auckland City Hospital
Grafton, Auckland, New Zealand Recruiting -
Oslo University Hospital
Oslo, Oslo, Norway Recruiting -
Hospital Universitari Germans Trias i Pujol
Badalona, Barcelona, Spain Recruiting -
Vall d'Hebron University Hospital
Barcelona, Barcelona, Spain Recruiting -
Karolinska University Hospital
Stockholm, Stockholm County, Sweden Recruiting -
University Hospital Linköping
Linköping, Östergötland County, Sweden Recruiting -
Klinik Hirslanden
Zurich, Canton of Zurich, Switzerland Recruiting -
Aintree University Hospital
Liverpool, Merseyside, United Kingdom Recruiting -
Newcastle upon Tyne Hospitals
Newcastle upon Tyne, North East England, United Kingdom Recruiting -
Queen Elizabeth Hospital
Birmingham, West Midlands, United Kingdom Recruiting -
Erasmus MC
Rotterdam, South Holland, Netherlands Not yet recruiting
Study contacts
- Principal investigator: Ronald Van Dam, Dr. — Maastricht Universitair Medisch Centrum
- Study coordinator: Fenna Van der Zijden, Dr.
- Email: fenna.van.der.zijden@mumc.nl
- Phone: +316 40911632
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.