Condition

Colon Cancer clinical trials and research

• 104Clinical trials
• 82NIH research projects
• 1New in 30 days
• 28Countries

Newest Colon Cancer clinical trials

All recruiting trials (104)

• LTZ-232: a first-in-human test in advanced colorectal and other solid tumors

  A first-in-human study tests LTZ-232, a new therapy for adults with unresectable or metastatic colorectal cancer and other solid tumors that have not responded to standard treatments.

  Recruiting Phase 1 LTZ Therapeutics, Inc. · Scottsdale, Arizona · NCT07878988

• ctDNA-Guided Immunotherapy for dMMR/MSI-H Colon Cancer

  This study tests whether tracking ctDNA can guide neoadjuvant immunotherapy and surgical decisions for people with dMMR/MSI-H colon cancer, using PD-1 inhibitors first and adding CTLA-4 inhibitors if ctDNA remains detectable.

  Recruiting Phase 2 Fudan University · Shanghai · NCT07841236

• Tafolecimab with chemoimmunotherapy as neoadjuvant treatment for locally advanced colon cancer

  This study tests whether adding tafolecimab to a chemoimmunotherapy regimen helps shrink locally advanced colon cancer before surgery in adults who have pMMR/MSS tumors.

  Recruiting Phase 2 Daping Hospital and the Research Institute of Surgery of the Third Military Medical University · Chongqing, Chongqing Municipality · NCT07840677

• Neoadjuvant pembrolizumab and porustobart for resectable MSS colon cancer

  This trial tests whether giving pembrolizumab with porustobart before surgery can shrink MSS colon cancer and improve outcomes, comparing one versus two doses of porustobart.

  Recruiting at 3 sites Phase 2 Solstice Oncology, Inc. · Los Angeles, California and 29 other locations · NCT07808151

• DEM301 in advanced colorectal cancer: a first-in-human test

  This first-in-human Phase 1 study tests DEM301 in adults with advanced metastatic colorectal cancer to see if it is safe, how it behaves in the body, and whether it shows any signs of activity.

  Recruiting at 2 sites Phase 1 DEM BioPharma, Inc. · Birtinya, Queensland and 1 other locations · NCT07805369

• SHY-ONC6: a new anti-cancer drug tested in adults with advanced solid tumors

  This early-phase study tests SHY-ONC6 to see if it is safe and can help people with advanced solid tumors after standard therapies have failed.

  Recruiting at 3 sites Phase 1 SHY Therapeutics · Scottsdale, Arizona and 2 other locations · NCT07705334

• See if Nuvastatic helps with cancer-related fatigue in colon cancer patients on first-line chemotherapy

  This trial tests whether Nuvastatic can lessen fatigue in adults with colon cancer who are receiving their first round of chemotherapy, compared to placebo.

  Recruiting at 6 sites Phase 3 Natureceuticals Sdn Bhd · Srikakulam, Andhra Pradesh and 5 other locations · NCT07669519

• Nuvastatic 300mg Capsule in metastatic colorectal cancer patients on first-line chemotherapy

  This trial tests whether Nuvastatic 300mg capsules can lessen cancer-related fatigue in adults with metastatic colorectal cancer receiving standard first-line chemotherapy, compared with a placebo.

  Recruiting at 6 sites Phase 3 Natureceuticals Sdn Bhd · Visakhapatnam, Andhra Pradesh and 5 other locations · NCT07669454

• Bowel cleaning versus no bowel cleaning before laparoscopic right colectomy with internal (intracorporeal) anastomosis

  This trial will test whether doing a mechanical bowel preparation (bowel cleaning) before elective laparoscopic right hemicolectomy with intracorporeal anastomosis for stage I–III colon cancer changes surgical site infection rates and recovery.

  Recruiting University Medical Center Ho Chi Minh City (UMC) · Ho Chi Minh City, Ho Chi Minh · NCT07546565

• Nutritional and activity program to support recovery after colon cancer surgery

  This study will test whether combining an HMB- and vitamin D–enriched nutritional supplement with a structured postoperative physical activity program helps adults with stage I–III colon cancer regain muscle strength and function after surgery.

  Recruiting Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud · Málaga, Malaga · NCT07534852

• MIMICC: stool and saliva molecular profiling in colorectal cancer

  This project will test whether stool and saliva microRNA and microbiome markers can help diagnose and monitor colon or rectal cancer in adults aged 18–75 who are having surgery or other treatment.

  Recruiting Fondazione del Piemonte per l'Oncologia · Candiolo, Torino (TO) · NCT07494201

• Cutting down ultra-processed foods for people at high cancer risk

  This project tests whether using the Open Food Facts smartphone app alongside nutrition education helps adults at high risk of cancer eat fewer ultra-processed foods.

  Recruiting at 2 sites Gustave Roussy, Cancer Campus, Grand Paris · Avignon and 2 other locations · NCT07436312

• Quality of life after colorectal cancer treatment

  This project will test whether late side effects at 6, 12, and 24 months affect quality of life in people aged 25–65 who completed initial treatment for colorectal cancer at the Institute of Oncology Ljubljana.

  Recruiting Institute of Oncology Ljubljana · Ljubljana · NCT07427901

• Digital app to support oncologist‑initiated genetic testing

  This project tests a digital app (GA‑Mainstream) to help oncologists offer germline genetic testing to adults with breast, prostate, colon, or other GI cancers.

  Recruiting at 2 sites Unity Health Toronto · Toronto, Ontario and 1 other locations · NCT07387263

• CBI-1214 T-cell engager for advanced MSS/MSI-L colorectal cancer

  This trial will test whether the experimental T-cell engager CBI-1214 is safe, reaches appropriate blood levels, and can shrink tumors in people with advanced or metastatic MSS/MSI-L colorectal cancer who have had prior treatment.

  Recruiting at 10 sites Phase 1 Cartography Biosciences · Phoenix, Arizona and 9 other locations · NCT07321106

• Surgical gloves to prevent hand neuropathy from oxaliplatin

  This trial will test whether wearing surgical gloves during oxaliplatin chemotherapy can prevent hand numbness and pain in adults with colon cancer.

  Recruiting AC Camargo Cancer Center · São Paulo, São Paulo · NCT07285356

• Node-sparing low-dose radiotherapy combined with chemotherapy and PD-1 blocker for high-risk pMMR/MSS locally advanced colon cancer.

  This trial tests whether adding node-sparing low-dose radiotherapy to standard chemotherapy and a PD-1 blocker can improve tumor response in adults with high-risk, locally advanced pMMR/MSS colon cancer before surgery.

  Recruiting Phase 2 Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT07279077

• Improving colon cancer scans with FAPI PET/CT

  This study will test whether a new PET tracer called 18F‑FAPI‑74 gives clearer whole-body images to find lymph node spread and distant metastases in people with colon cancer.

  Recruiting Phase 2/3 Turku University Hospital · Turku · NCT07272772

• Blood test of exosomal microRNAs to stage colon cancer before surgery

  This project will try a blood test that measures tumor-released exosomal microRNAs to see if it can identify patients with higher-risk colon cancer before surgery.

  Recruiting City of Hope Medical Center · Duarte, California · NCT07255729

• EXoPERT EMERALD: a blood test using AI on extracellular vesicles to detect early lung, breast, colorectal, pancreatic, and ovarian cancers.

  This test tries to detect early lung, breast, colorectal, pancreatic, and ovarian cancers from a single blood sample by using AI to read Raman spectroscopy patterns of tiny particles called extracellular vesicles.

  Recruiting at 9 sites EXoPERT · Long Beach, California and 8 other locations · NCT07186296

• CEA-targeted CAR-T for advanced CEA-positive solid tumors

  This trial will try CEA-targeted CAR-T cell infusions in adults with advanced CEA-positive cancers (such as colorectal, gastric, esophageal, lung, or pancreatic cancer) to see if the treatment is safe and helps control the disease.

  Recruiting Phase 1 Chongqing Precision Biotech Co., Ltd · Hefei, Anhui · NCT07179692

• Leakage risk after ileo-colic sutures using MonoPlus® following right hemicolectomy

  This will try MonoPlus® suture material for ileo-colic anastomosis in adults having elective right hemicolectomy for colon cancer to see if the 30-day leakage rate is not higher than published rates.

  Recruiting at 4 sites Aesculap AG · Göppingen, Baden-Wurttemberg and 3 other locations · NCT07132970

• PHN-012 for people with advanced colon, lung (NSCLC), or pancreatic cancer.

  This trial will try PHN-012, a new antibody-drug conjugate, in people with advanced colon, non-small cell lung, or pancreatic cancer who have already received other treatments.

  Recruiting at 26 sites Phase 1 Pheon Therapeutics · Los Angeles, California and 25 other locations · NCT07127874

• Group program to promote post-traumatic growth for adults with breast, colorectal, or head and neck cancer in Greece

  This project will try a manualized, group-based ACT program to help Greek adults who finished chemotherapy for breast, colorectal, or head and neck cancer increase post-traumatic growth and quality of life.

  Recruiting Centre for Research and Technology Hellas · Thessaloniki · NCT07108517

• Preserving the superior left colic artery to improve blood flow to the descending colon before reconnecting the bowel after left-sided, rectal, or ovarian cancer surgery

  This trial will test in adults having left colon, rectal, or ovarian cancer surgery whether preserving the superior left colic artery and temporarily managing the inferior mesenteric artery improves blood flow to the descending colon and reduces healing problems after the bowel is reconnected.

  Recruiting Institut du Cancer de Montpellier - Val d'Aurelle · Montpellier, Herault · NCT07098182

• Virtual exercise program to preserve function and prevent disability during chemotherapy

  This trial tests whether supervised resistance sessions by video plus short home aerobic workouts help adults 18–64 maintain strength and stay active while receiving curative-intent chemotherapy.

  Recruiting at 29 sites Alliance for Clinical Trials in Oncology · Dublin, California and 29 other locations · NCT07059884

• Fruquintinib plus FOLFIRI for second-line metastatic colorectal cancer

  This study will test whether adding fruquintinib to FOLFIRI helps people with metastatic colorectal cancer who progressed after first-line FOLFOX plus bevacizumab.

  Recruiting at 14 sites Phase 2 SCRI Development Innovations, LLC · Denver, Colorado and 13 other locations · NCT07011576

• Online and in-person exercise programs for cancer survivors in Canada

  This study is testing whether online and in-person exercise programs can help cancer survivors in Canada stay active and improve their health.

  Recruiting at 5 sites University of Calgary · Calgary, Alberta and 4 other locations · NCT06960291

• Combining radiotherapy and systemic therapy for advanced colon cancer

  This study is testing whether combining radiation therapy with chemotherapy and immune treatments can help people with advanced colon cancer have better surgery outcomes and improve their overall health.

  Recruiting Phase 2 Hebei Medical University Fourth Hospital · Shijiazhuang, Hebei · NCT06949111

• Endoscopic full-thickness resection versus surgery for early colon cancer

  This test tries whether a minimally invasive endoscopic full-thickness resection (eFTR) works as well as standard surgery for people with newly diagnosed small (≤20 mm) early colon cancer who have no high-risk biopsy features.

  Recruiting Phase 3 Norwegian Department of Health and Social Affairs · Gdansk · NCT06940947

• Chronic Loose Stools After Right-Sided Colectomy: How Bile Acids and Gut Bacteria Might Link to Symptoms

  This study tests whether bile acid metabolism and small intestinal bacteria relate to chronic loose stools in patients after right-sided colectomy or total colectomy.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT06927011

• IV lidocaine during colon cancer surgery to lower inflammation and speed recovery

  This trial will test if an intravenous lidocaine infusion given around the time of surgery can lower inflammation, reduce pain and opioid use, and help bowel function recover faster in adults having laparoscopic colon cancer surgery.

  Recruiting Phase 2 Institute of Oncology Ljubljana · Ljubljana and 1 other locations · NCT06923787

• Intensified omeprazole treatment to reduce high-output stoma in ileostomy patients

  This study tests if a stronger dose of omeprazole can help adults with ileostomy surgery have less stoma output and stay out of the hospital longer.

  Recruiting at 2 sites Medical University of Gdansk · Gdansk, Pomeranian Voivodeship and 1 other locations · NCT06917963

• Optimized ERAS 3.0 home recovery program for older adults after colon cancer surgery

  This trial will test whether a home-based ERAS 3.0 program of geriatric assessment, diet counseling, and guided physical activity helps frail patients aged 65 and older recover better after colon cancer surgery.

  Recruiting Copenhagen University Hospital at Herlev · Herlev and 1 other locations · NCT06802991

• Imaging method for digestive system cancer using targeted PET scans

  This study is testing a new type of PET scan to see if it can better help doctors find and diagnose cancers in the digestive system.

  Recruiting RenJi Hospital · Shanghai, Shanghai Municipality · NCT06715839

• Evaluating QL1706 for Treating Resectable Colon Cancer

  This study is testing a new treatment called QL1706 for people with certain types of colon cancer to see if it can help them during their surgery and recovery.

  Recruiting Phase 3 Qilu Pharmaceutical Co., Ltd. · Guangzhou · NCT06686576

• Evaluating a new CAR T-cell therapy for solid tumors expressing EGFR

  This study is testing a new CAR T-cell therapy to see if it can safely help adults with certain solid tumors, like colorectal and lung cancer, that have specific markers.

  Recruiting at 10 sites Phase 1/2 A2 Biotherapeutics Inc. · Gilbert, Arizona and 9 other locations · NCT06682793

• Using brodalumab to treat immune-related side effects from cancer therapy

  This study is testing if brodalumab can help cancer patients who are having immune-related side effects from their immunotherapy treatment feel better.

  Recruiting Phase 1 Columbia University · New York, New York · NCT06673329

• Minimally invasive surgery for early-stage colon cancer

  This study is testing a new, less invasive surgery for early-stage colon cancer to see if it can lower the chances of cancer coming back compared to the standard surgery.

  Recruiting Meander Medical Center · Amersfoort · NCT06652672

• Using ctDNA to guide chemotherapy for elderly colon cancer patients after surgery

  This study tests if using a blood test to check for cancer DNA can help doctors decide the best chemotherapy for older patients with high-risk colon cancer after surgery.

  Recruiting Phase 3 Zhejiang Cancer Hospital · Hangzhou, Zhejiang · NCT06609551

• Exploring the links between cancer, undernutrition, and sensory changes

  This study looks at how newly diagnosed cancers in the mouth, throat, colon, and liver affect patients' nutrition and senses like taste and smell, to see how these changes impact their eating habits and quality of life.

  Recruiting Centre Hospitalier Universitaire Dijon · Dijon · NCT06600295

• Using immune checkpoint inhibitors to preserve organs in non-metastatic gastric or colon cancers

  This study is testing a new combination of immune treatments to see if it can help people with non-metastatic gastric or colon cancers keep their organs and improve their health before surgery.

  Recruiting Phase 2 Peking University · Beijing, Beijing Municipality · NCT06580574

• Treatment for advanced colon and rectal cancer using immune cells

  This study is testing a new treatment that uses the patient's own immune cells combined with other medications to see if it can help people with advanced colon and rectal cancer feel better and live longer.

  Recruiting Phase 1/2 Essen Biotech · Beijing, Beijing Municipality · NCT06530303

• Injecting a virus directly into tumors to treat advanced cancers

  This study is testing whether injecting a special virus directly into tumors can be safe and help people with advanced solid cancers.

  Recruiting Phase 1 GONGCHU Biotechnology Co., Ltd · Zhengzhou, Henan · NCT06508307

• Comparing two surgical methods for treating right colon cancer

  This study tests whether using special imaging during surgery helps people with right colon cancer recover better than just having the standard surgery alone.

  Recruiting Sun Yat-sen University · Guangzhou · NCT06485609

• Analyzing shopping habits to improve early cancer diagnosis

  This study is trying to see if changes in shopping habits can help spot cancer earlier by looking at purchase data from loyalty cards of people recently diagnosed with cancer and those without it.

  Recruiting Imperial College London · London · NCT06447064

• Pre-surgery chemotherapy followed by immunotherapy for locally advanced colon cancer

  This trial will see if giving CAPEOX chemotherapy before surgery and then adding the immunotherapy serplulimab helps adults with locally advanced, MSS/RAS-mutant colon cancer get better tumor responses and live longer.

  Recruiting Phase 2 Ruijin Hospital · Shanghai, Shanghai Municipality · NCT06368141

• Engaging cancer patients in genomic testing decisions

  This study is testing if letting cancer patients choose what genetic information they want to receive helps them feel more informed and satisfied with their health decisions.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT06340646

• Personalizing chemotherapy for older patients with advanced colon cancer

  This study is testing a personalized chemotherapy plan for older patients with advanced colon cancer to see if it can improve their treatment before surgery.

  Recruiting Phase 3 Centre Hospitalier Universitaire Dijon · Dijon · NCT06293625

• Heart-rate variability biofeedback for cancer patients

  This study is testing whether heart-rate variability biofeedback can help improve the well-being and treatment outcomes for breast and colon cancer patients.

  Recruiting Comenius University · Bratislava · NCT06281145

• Using zebrafish avatars to personalize colon cancer treatment

  This study is testing whether using zebrafish to mimic a patient's colon cancer can help doctors find the best treatment for them.

  Recruiting Phase 1/2 University Hospital, Linkoeping · Linköping, Östergötland County · NCT06270017

• Improving care for Black patients with gastrointestinal cancer

  This study is trying to improve cancer care for Black patients with gastrointestinal cancers by ensuring they get the right tests and treatments while helping us understand the challenges they face.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT06263088

• Using ctDNA to improve chemotherapy for stage III colon cancer

  This study is testing whether using blood tests to check for tumor DNA can help doctors give better chemotherapy to people with stage III colon cancer after surgery.

  Recruiting at 9 sites Phase 2 West China Hospital · Guiyang, Guizhou and 8 other locations · NCT06242418

• Testing MDX2001 for advanced solid tumors

  This study is testing a new drug called MDX2001 to see if it can safely help people with advanced solid tumors like breast or colon cancer.

  Recruiting at 6 sites Phase 1/2 ModeX Therapeutics, An OPKO Health Company · Denver, Colorado and 5 other locations · NCT06239194

• Using blood tests to manage gastrointestinal tumors

  This study is testing if blood tests that look for tumor DNA can help doctors better manage patients with gastrointestinal tumors like pancreatic, colon, and biliary tract cancers.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Rome, Lazio · NCT06202131

• Treatment using CEA-targeted CAR-T cells for advanced solid tumors

  This study is testing a new type of immune therapy using CAR-T cells to see if it can help people with advanced solid tumors that have a specific marker called CEA.

  Recruiting Phase 1 Chongqing Precision Biotech Co., Ltd · Wuhu, Anhui · NCT06126406

• Chemotherapy before surgery for obstructing colon cancer treated first with a diverting stoma

  This trial will test whether giving chemotherapy before surgery helps adults with non-metastatic obstructive colon cancer who’ve had a diverting stoma to complete all planned cancer treatments.

  Recruiting at 28 sites Phase 3 University Hospital, Rouen · Amiens and 27 other locations · NCT06107920

• COMBO endoscopy oropharyngeal airway for safer propofol‑sedated gastrointestinal endoscopy

  This trial will test whether the COMBO Endoscopy Oropharyngeal Airway reduces low-oxygen episodes in adults having propofol‑sedated gastroscopy or colonoscopy compared with a regular nasal cannula.

  Recruiting at 10 sites RenJi Hospital · Nanjing, Jiangsu and 9 other locations · NCT06081647

• Evaluating a new CAR T-cell therapy for solid tumors expressing MSLN

  This study is testing a new CAR T-cell therapy to see if it can safely treat adults with solid tumors like colorectal and lung cancer that express a specific protein.

  Recruiting at 12 sites Phase 1/2 A2 Biotherapeutics Inc. · Gilbert, Arizona and 11 other locations · NCT06051695

• Personalized T cell therapy targeting KRAS G12V in metastatic solid tumors

  This trial tests whether giving a patient's own modified CD8+ and CD4+ T cells engineered to recognize the KRAS G12V mutation can help people with metastatic solid tumors that carry that mutation.

  Recruiting Phase 1 Fred Hutchinson Cancer Center · Seattle, Washington · NCT06043713

• Platform program for evaluating treatments in metastatic HER2-positive breast cancer

  This study is testing different new treatments for people with advanced HER2-positive breast cancer to see which ones work best before moving them to larger trials.

  Recruiting at 5 sites Phase 1/2 QuantumLeap Healthcare Collaborative · Birmingham, Alabama and 9 other locations · NCT05868226

• Combination treatment for late-stage metastatic colorectal cancer

  This study is testing a new combination of treatments for people with late-stage metastatic colorectal cancer to see if it can help control their disease and extend the time before it gets worse.

  Recruiting at 9 sites Phase 2 Rutgers, The State University of New Jersey · Elizabeth, New Jersey and 8 other locations · NCT05806931

• Organ-sparing surgery for elderly patients with early colon cancer

  This study is testing a new, less invasive surgery for older patients with early colon cancer to see if it can be safer and easier than traditional surgery.

  Recruiting at 2 sites Zealand University Hospital · Copenhagen, Herlev and 2 other locations · NCT05734300

• Comparing laparoscopic and open surgery for right colon cancer

  This study is testing whether laparoscopic surgery or open surgery is better for patients with right colon cancer in terms of recovery and cancer outcomes.

  Recruiting Larissa University Hospital · Larissa · NCT05713903

• Using a Traditional Chinese medicine to prevent colon cancer recurrence

  This study is testing if a traditional Chinese medicine can help prevent colon cancer from coming back in people who have just finished their chemotherapy.

  Recruiting Phase 3 Jiangsu Famous Medical Technology Co., Ltd. · Nanjing · NCT05709249

• Observational study on outcomes of advanced pelvic cancer surgeries

  This study looks at how well patients do after having complex surgeries for advanced pelvic cancer to see what challenges they face and how to improve their care.

  Recruiting Glasgow Royal Infirmary · Glasgow · NCT05696002

• Training healthcare providers in Nigeria for colorectal cancer screening and diagnosis

  This study is testing a new training program for healthcare providers in Nigeria to help them become better at screening and diagnosing colorectal cancer.

  Recruiting at 2 sites Obafemi Awolowo University Teaching Hospital · Ile-Ife, Osun State and 1 other locations · NCT05686499

• Treatment for lung cancer using targeted chemotherapy delivery

  This study is testing a new way to deliver chemotherapy directly to lung tumors in patients with hard-to-treat lung cancer to see if it helps control tumor growth better than standard treatments.

  Recruiting at 2 sites Phase 2 City of Hope Medical Center · Duarte, California and 1 other locations · NCT05672108

• Predicting responses to chemotherapy in gastrointestinal cancer using organoids

  This study is testing if lab-grown mini tumors from patients with gastric or colon cancer can help doctors find the best chemotherapy drugs to improve treatment outcomes.

  Recruiting at 4 sites Technische Universität Dresden · Berlin and 4 other locations · NCT05652348

• Intensified chemotherapy for colon cancer based on ctDNA results

  This study is testing if a stronger chemotherapy treatment can help people with stage 2-3 colon cancer who still have signs of cancer after standard treatment live longer and stay cancer-free.

  Recruiting at 13 sites Phase 3 Seoul National University Hospital · Busan and 12 other locations · NCT05534087

• Using circulating tumor DNA to guide chemotherapy for colon cancer

  This study tests if using blood samples to check for cancer DNA can help doctors decide how much chemotherapy colon cancer patients really need to improve their treatment outcomes.

  Recruiting Peking University Cancer Hospital & Institute · Beijing, Beijing Municipality · NCT05529615

• Comparing two surgical methods for right colon cancer treatment

  This study is testing whether a new surgical method for treating right colon cancer is as effective as the standard laparoscopic surgery for women aged 18-75.

  Recruiting Shanghai Minimally Invasive Surgery Center · Shanghai · NCT05495048

• Testing drug sensitivity in micro tumors to guide treatment for colorectal cancer

  This study is testing whether a new 3D drug sensitivity test on tiny tumors can help guide better treatment decisions for people with colorectal cancer after surgery.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT05424692

• Evaluating the safety of a new treatment for certain cancer types

  This study is testing a new treatment for certain types of cancer to see if it's safe for adults with recurrent or metastatic tumors.

  Recruiting at 4 sites Phase 1 Orano Med LLC · Chicago, Illinois and 7 other locations · NCT05283330

• Database for understanding cachexia in colon cancer patients

  This study is trying to gather information about weight loss and nutrition in colon cancer patients to see how it affects their treatment and overall health.

  Recruiting Institut du Cancer de Montpellier - Val d'Aurelle · Montpellier · NCT05257135

• Assessing HIPEC with Mitomycin C for Colon Cancer with Peritoneal Metastases

  This study is testing if a heated chemotherapy treatment called HIPEC with Mitomycin C can help people with colon cancer that has spread to the abdominal lining do better after surgery.

  Recruiting at 28 sites Phase 4 Hospital Universitario de Fuenlabrada · Elche, Alicante and 30 other locations · NCT05250648

• Neoadjuvant treatment with dostarlimab for advanced colon cancer

  This study is testing if the immunotherapy drug dostarlimab can shrink tumors in patients with advanced colon cancer so they might not need surgery.

  Recruiting at 2 sites Phase 2 University of Iowa · Iowa City, Iowa and 1 other locations · NCT05239546

• Understanding cancer through genomic profiling and analytics

  This study is trying to understand the genetic features of different types of cancer in people from a community healthcare system to improve screening and treatment options.

  Recruiting at 6 sites Avera McKennan Hospital & University Health Center · Marshall, Minnesota and 5 other locations · NCT05142033

• Comparing two methods for removing large colorectal adenomas

  This study is testing whether a new method that combines two techniques for removing large colorectal adenomas during colonoscopy works better than using just one of the techniques alone for patients with these types of growths.

  Recruiting Western Sydney Local Health District · Westmead, New South Wales · NCT05041478

• Investigating metastasis in colon cancer patients undergoing surgery

  This study is testing how removing certain parts of the mesentery during colon cancer surgery affects the safety and outcomes for patients with tumors near the liver.

  Recruiting Tongji Hospital · Wuhan, Hubei · NCT04980287

• Using mesalamine to prevent colorectal cancer in Lynch Syndrome patients

  This study is testing if taking mesalamine can help prevent colorectal cancer in people with Lynch Syndrome.

  Recruiting at 5 sites Phase 2 Karolinska University Hospital · Aalborg and 7 other locations · NCT04920149

• Improving care for rural patients with solid tumors

  This study is testing a new support program to see if it helps rural patients with solid tumors start and finish their treatment faster compared to usual care.

  Recruiting at 14 sites University of Colorado, Denver · Aurora, Colorado and 13 other locations · NCT04916990

• Using virtual reality to help manage pain in GI cancer patients

  This study is testing if virtual reality can help people with GI cancer manage their severe abdominal pain better than standard treatments.

  Recruiting Cedars-Sinai Medical Center · Los Angeles, California · NCT04907643

• Comparing two surgical methods for right colon cancer treatment

  This study is testing two different surgical methods for treating right colon cancer to see which one helps patients live longer and feel better after surgery.

  Recruiting University of Turin, Italy · Grosseto, Arezzo and 13 other locations · NCT04871399

• Training to prevent hernias after stoma surgery

  This study tests whether special abdominal exercises can help prevent hernias in patients who have had stoma surgery for colon cancer.

  Recruiting at 4 sites Göteborg University · Gothenburg and 3 other locations · NCT04701853

• Treatment of advanced cancers with RSC-1255

  This study is testing a new oral drug called RSC-1255 to see if it can help adults with advanced cancers that haven't responded to other treatments.

  Recruiting at 3 sites Phase 1 RasCal Therapeutics, Inc. · Los Angeles, California and 2 other locations · NCT04678648

• Improving cancer care for older adults with gastrointestinal cancers

  This study is testing a new way to improve cancer care for older adults with gastrointestinal cancers by adding special consultations to their treatment plans.

  Recruiting Dana-Farber Cancer Institute · Boston, Massachusetts · NCT04674267

• Biopsy to study tumor changes after radioembolization

  This study is trying to see how tumors in patients with colorectal cancer that has spread to the liver change after they receive a specific radiation treatment called radioembolization.

  Recruiting Memorial Sloan Kettering Cancer Center · New York, New York · NCT04668872

• Comparing single-incision and conventional laparoscopic surgery for colorectal cancer outcomes

  This study is testing if a newer type of surgery with one small cut can help people with colorectal cancer have less pain and better healing compared to the usual surgery with multiple cuts.

  Recruiting at 11 sites Ruijin Hospital · Lanzhou, Gansu and 10 other locations · NCT04527861

• Using stereotactic body radiotherapy for patients with rare oligometastatic cancers

  This study is testing if adding a special type of targeted radiation therapy to standard treatment can help people with rare cancers that have spread to a few places live longer and feel better.

  Recruiting at 13 sites European Organisation for Research and Treatment of Cancer - EORTC · Anderlecht and 12 other locations · NCT04498767

• Exercise programs for cancer survivors in rural areas

  This study is testing community and online exercise programs for cancer survivors in rural areas to see if they can help improve their quality of life and encourage long-term fitness habits.

  Recruiting University of Calgary · Calgary, Alberta and 2 other locations · NCT04478851

• Comparing two approaches for treating acute colon cancer obstruction

  This study is testing whether a two-step treatment for colon cancer obstruction, which involves using a stent or stoma, works better than immediate surgery in helping patients recover and live longer.

  Recruiting Skane University Hospital · Gothenburg · NCT04450758

• Comparing D2 and D3 lymph node dissection for left colon cancer

  This study tests whether a new surgical technique for removing lymph nodes during left colon cancer surgery can help patients live longer and have better outcomes compared to the standard method.

  Recruiting Russian Society of Colorectal Surgeons · Moscow · NCT04364373

• Using blood tests to assess early treatment response in cancer patients

  This study is testing if blood tests that look for cancer DNA can help doctors see how well treatment is working for patients with different types of solid tumors.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT04354064

• Analysis of blood tumor markers for cancer diagnosis and treatment monitoring

  This study is testing whether a simple blood test can replace traditional tissue biopsies to help diagnose cancer and monitor how well treatments are working.

  Recruiting at 2 sites Institut du Cancer de Montpellier - Val d'Aurelle · Montpellier and 1 other locations · NCT04025541

• Developing a liquid biopsy protocol for cancer research at Princess Margaret

  This study is trying to create a simple way to collect blood samples from cancer patients to see if analyzing certain molecules in their blood can help doctors understand their cancer better and track how it changes over time.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT03702309

• Imaging, Blood, and Tissue Samples to Guide Colon Cancer and Liver Tumor Care

  This study tests whether combining imaging, blood, and tissue samples can help tailor treatment for people with colon cancer and related liver tumors.

  Recruiting at 4 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 3 other locations · NCT03432806

• Using modified immune cells to target specific cancer mutations

  This study is testing a new treatment that uses modified immune cells to target and attack tumors with a specific cancer mutation in patients with advanced pancreatic and colorectal cancer.

  Recruiting Phase 1/2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT03190941

• Treatment of advanced solid tumors with APL-101 for specific genetic mutations

  This study is testing a new oral medication called APL-101 to see if it helps people with advanced lung cancer and other solid tumors that have certain genetic changes, especially those who haven't had success with standard treatments.

  Recruiting at 32 sites Phase 2 Apollomics Inc. · Los Angeles, California and 34 other locations · NCT03175224

• Exploring the impact of genomic sequencing on understanding cancer risks

  This study is testing how genomic sequencing can help people with rare diseases understand their cancer risks and whether they take action based on the results.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT02595957

• A resource for collecting cancer data and biospecimens

  This study is creating a resource to collect health information and samples from cancer patients and healthy individuals to help improve cancer prevention and treatment strategies.

  Recruiting at 42 sites University of Nebraska · Greenwood Village, Colorado and 41 other locations · NCT02012699

• Understanding genetic causes of lymphoproliferative disorders in families

  This study is trying to find out how genetics play a role in lymphoproliferative disorders, like Hodgkin's disease and lymphoma, by looking at families with a history of these cancers.

  Recruiting at 6 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 5 other locations · NCT00582621

• Long-term follow-up for patients previously treated with poxviral vector gene therapy

  This study is checking on the long-term health of cancer patients who received poxviral vector gene therapy to see how they are doing years later.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00451022

• Collecting blood samples from cancer patients

  This study is collecting blood samples from cancer patients to see how their immune cells change before and after chemotherapy.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00034216

NIH-funded research (newest 40 of 82)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Colon Cancer Family Registry Cohort study for smarter prevention and care

  A large international group is following thousands of people with colorectal cancer and their relatives to better understand risk, causes, and outcomes so future patients can get better guidance and treatment.

  NIH research University of Melbourne · Melbourne, Australia · NIH-11513998

• Bioengineered Networking Microbes for Targeted Colon Cancer Therapy

  A project tests a engineered bacteria-based therapy designed to target colon tumors and boost the body’s immune response in people with colon cancer.

  NIH research Arizona State University-Tempe Campus · Scottsdale, United States · NIH-11457613

• How DNA methylation patterns are kept in colon cancer and what happens when they’re disrupted

  Researchers are studying how the molecular marks that control gene activity are maintained in colon cancer and how breaking these marks affects cancer growth and treatment response.

  NIH research Van Andel Research Institute · Grand Rapids, United States · NIH-11447596

• Adaptive aerobic exercise plans during chemotherapy for colon cancer

  This study tests personalized aerobic exercise during chemotherapy for people with colon cancer to help them stay on their planned treatment schedule and reduce side effects.

  NIH research Adventhealth Orlando · Orlando, United States · NIH-11419227

• Immune regulation in colon cancer and its spread to lymph nodes and liver

  A patient-friendly look at how immune system circuits in colorectal cancer and its metastases may influence treatment responses and outcomes.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11415153

• Biomarker discovery in colon cancer with advanced metabolomics

  A new project will use advanced chemical analysis to find blood- and tissue-based markers that indicate colon cancer and its progression.

  NIH research Panome Bio INC · Saint Louis, United States · NIH-11404018

• Origins of tumor-reactive regulatory T cells in colorectal cancer patients

  This grant explores how certain immune cells that can dampen anti-tumor responses (regulatory T cells) arise and behave in colon cancer, with the goal of understanding and potentially guiding better treatments for patients.

  NIH research Providence Health & Services - Oregon · Renton, United States · NIH-11374311

• Colon cancer, blood vessels, and smooth muscle changes linked by PDGFR-B signaling

  A researcher is studying how colon cancer and cardiovascular disease interact, focusing on how cancer may influence artery walls through PDGFR-B signaling.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11371452

• Targeting mutant KRAS in metastatic colon cancer with RNA-loaded exosomes and CRISPR components

  A patient-focused grant exploring a new way to silence mutant KRAS in metastatic colon cancer using RNA-loaded exosomes to deliver CRISPR components and KRAS-targeting siRNA.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11369670

• Understanding how DNA methylation changes drive colon cancer and how we might fix them

  A study to uncover how epigenetic marks that control gene activity go wrong in colon cancer and explore ways to target these changes for better treatment.

  NIH research Van Andel Research Institute · Grand Rapids, United States · NIH-11364229

• Bacteria-made compounds to prevent colon cancer linked to GPR109A and ketone metabolism

  This grant tests how bacterial byproducts and ketone-related signals in the gut might help prevent colon cancer by engaging GPR109A and p53 pathways.

  NIH research Augusta University · Augusta, United States · NIH-11361675

• Engineered Colon Cancer Tissue in Obese Environments

  Aims to study how obesity-related changes in the tumor environment influence colorectal cancer using patient-derived, lab-made colon cancer models.

  NIH research Auburn University at Auburn · Auburn, UNITED STATES · NIH-11355575

• Targeting SUMO1 to attack advanced colon cancer

  A new approach aims to use tiny molecules to break down SUMO1, a protein linked to aggressive colon cancers, to improve treatment for patients with advanced disease.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11355551

• Adaptive aerobic exercise during colon cancer chemotherapy

  This program uses tailored aerobic exercise during chemotherapy to help people with stage II–III colon cancer complete their chemo doses and reduce side effects.

  NIH research Adventhealth Orlando · Orlando, United States · NIH-11350996

• Targeting CLDN1 to overcome chemoresistance and curb metastasis in colon cancer

  A new drug candidate that blocks CLDN1 may help people with colon cancer respond better to chemotherapy and reduce spread.

  NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11324005

• Monitoring online information and communication gaps about colon cancer screening

  This project uses computer language tools and input from crowd volunteers to find what information people see and share online about colon cancer screening, especially for groups less likely to get screened.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11322064

• Optical nanoscale chromatin test to guide colon cancer screening

  A new, affordable test using AI-enhanced light to spot dangerous changes in cell DNA from a simple sample, helping doctors decide who should get a colonoscopy.

  NIH research Northwestern University · Chicago, United States · NIH-11318966

• How aerobic exercise affects muscle health in colon cancer survivors

  This study is looking at how a regular exercise program can help improve muscle health and strength in people who have survived colon cancer, with the goal of boosting their overall well-being and lowering the chances of cancer coming back.

  NIH research Adventhealth Orlando · Orlando, United States · NIH-11317318

• Targeting enteric glia to overcome chemotherapy resistance in colon cancer

  Researchers aim to block signals from gut support cells called enteric glia so chemotherapy can kill colon cancer cells more effectively.

  NIH research North Carolina State University Raleigh · Raleigh, United States · NIH-11311353

• Boosting immune cell fat-burning to help fight metastatic colon cancer

  This project tries to turn on a fat-burning program in immune cells to help immunotherapy work better for people with metastatic colorectal (colon) cancer, especially the common microsatellite-stable type.

  NIH research Cold Spring Harbor Laboratory · Cold Spring Harbor, United States · NIH-11309198

• ACSS2 and colon cancer

  This project aims to find out whether boosting a protein called ACSS2 can slow or prevent colon cancer by changing how tumor cells use short-chain fatty acids.

  NIH research University of Virginia · Charlottesville, United States · NIH-11294303

• How blocking a specific protein may help treat colon cancer

  This study is looking at a protein called claudin-1 that helps colon cancer spread, and it’s testing a new treatment that might make chemotherapy work better and stop the cancer from spreading further, all to help people with advanced colon cancer feel better and live longer.

  NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11291157

• Stopping colon cancer from spreading to the liver with a new drug approach

  Researchers are trying drugs that activate the dopamine D4 receptor, alone or with standard chemotherapy, to stop colon cancer from spreading to the liver in people at risk of liver metastases.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11289460

• Targeting fatty acid synthase to fight colon cancer

  This project is trying an oral drug that blocks a fat-making enzyme (FASN) to help people with colon cancer.

  NIH research University of Kentucky · Lexington, United States · NIH-11286775

• Blocking SUV39H1 to help treat colon cancer

  A new drug that blocks the SUV39H1 enzyme is being developed to help people with colorectal cancer, especially the common tumors that don't respond to PD‑1/PD‑L1 immunotherapy.

  NIH research Augusta University · Augusta, United States · NIH-11284052

• Understanding how colorectal polyps become cancer without mutations

  This grant studies the non-mutational steps that let colorectal polyps turn into cancer, using a new mouse model that mirrors human disease and helps identify when and why progression happens.

  NIH research Cold Spring Harbor Laboratory · Cold Spring Harbor, United States · NIH-11279349

• miR-146a: a tiny regulator that may block inflammation that feeds colon cancer

  This research explores whether boosting a small molecule called miR-146a can cut harmful IL-17 inflammation that helps colorectal cancer grow, for people with colorectal cancer.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11262326

• Blocking iRhom to improve colon cancer treatment

  This project will try blocking a protein called iRhom to help chemotherapy and immune-based treatments work better for people with colorectal cancer that usually doesn't respond to immunotherapy.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11257677

• ALOX15's role in colon cancer spread through PI3P and linoleic acid metabolism

  This grant explores how a specific enzyme, ALOX15, influences colon cancer invasiveness by changing a fat-related chemical pathway in the body.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11253934

• Boosting immune cells and blocking suppressive signals in colon cancer that has spread to the liver

  This project aims to increase immune-cell activity inside colon tumors and block signals that shut those cells down for adults with colon cancer that has spread to the liver.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11251932

• Investigating a new treatment to target colon cancer stem cells

  This study is looking at a new compound called G2.2 to see if it can help stop colon cancer stem cells from growing and spreading, which could lead to better treatments for people with colorectal cancer.

  NIH research VA Veterans Administration Hospital · Richmond, United States · NIH-11207158

• Immune cell circuits in primary colon tumors and their lymph node and liver metastases

  This project looks at how immune cells and their neighborhoods behave in people with the common pMMR form of colon cancer to find ways to make immunotherapy work better.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11176073

• How the mouth bacterium Parvimonas micra may change gene control in colon cells and promote colon cancer

  This project looks at whether a common mouth germ, Parvimonas micra, changes DNA methylation in colon cells and helps drive colorectal cancer in people.

  NIH research Mayo Clinic Arizona · Scottsdale, United States · NIH-11146520

• Boosting immune response against metastatic colon cancer

  This study is looking at ways to make cancer treatments work better for people with metastatic colorectal cancer by boosting the energy and effectiveness of certain immune cells, so they can fight the cancer more effectively.

  NIH research Cold Spring Harbor Laboratory · Cold Spring Harbor, United States · NIH-11142217

• How the PTPRT gene affects colon cancer growth and spread

  Researchers are looking at whether changes in a gene called PTPRT change how colon cancer grows and spreads, which could help people with colorectal cancer.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11137753

• New treatment approach for liver cancer spread from colon cancer

  This study is looking at a new way to help prevent liver cancer spread in people with colon cancer by testing a special treatment that works with certain receptors in the body, and it aims to see how well this treatment works alone or with other cancer medicines.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11133691

• Understanding Colon Cancer Growth in Obese Patients

  This project explores how obesity affects the growth and behavior of colon cancer cells to find new ways to help patients.

  NIH research Auburn University at Auburn · Auburn, UNITED STATES · NIH-11131100

• Understanding DNA Changes in Colon Cancer

  This research explores how abnormal DNA changes contribute to colon cancer and seeks new ways to target them.

  NIH research Van Andel Research Institute · Grand Rapids, United States · NIH-11129879

• Targeting Mutant KRAS in Colon Cancer Lung Metastasis with RNA Nanotechnology

  This project aims to develop a new way to deliver gene-silencing therapies directly to lung metastatic colon cancer cells that have a specific KRAS gene mutation.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11129835

• New medicines for advanced colon cancer

  This project aims to create new small-molecule drugs to treat advanced colon cancer, especially when current treatments are not working well.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11127751

Related topics

Quick answers

How many Colon Cancer clinical trials are recruiting right now?

104, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 28 countries. The most sites are in United States (37 trials), China (22 trials), France (9 trials), Italy (6 trials), Canada (5 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 15, Phase 1: 12, Phase 3: 9, Phase 1/2: 7. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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