Developing a markerless tracking method for real-time tumor motion measurement during radiation therapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to create a whole-of-body markerless tracking method to measure tumor and organ motion during radiation therapy. By utilizing routinely acquired patient data from 300 individuals with various cancers, the study will train, test, and validate this tracking method. The data will be processed through a clinical trial learning system that enhances the accuracy of the tracking software with each patient. The primary goal is to improve targeting accuracy in radiation therapy through advanced imaging techniques.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Will receive radiation therapy for brain, breast, head and neck, kidney, liver, pancreas, prostate, spine cancer treatment or cardiac arrhythmia treatment at a participating centre.
* Will receive CT planning, and a cone beam CT scan for at least one fraction of radiation therapy.
* Will receive intrafraction x-ray imaging for the liver, pancreas, prostate, spine cancer treatment or cardiac arrhythmia treatment. As intrafraction imaging is not common standard of care for brain, breast, head and neck and kidney cancer treatments there is no requirement to have intrafraction x-ray imaging data for these anatomical sites.
* Provides written informed consent.

Exclusion Criteria:

* Less than 18 years of age

Where it's running

• Royal North Shore Hospital
  Saint Leonards, New South Wales, Australia Recruiting
• Princess Alexandra Hospital
  Woolloongabba, Queensland, Australia Not yet recruiting
• Alfred Health
  Melbourne, Victoria, Australia Not yet recruiting
• Peter MacCallum Cancer Centre
  Melbourne, Victoria, Australia Not yet recruiting

Study contacts

• Study coordinator: Shona Silvester
• Email: shona.silvester@sydney.edu.au
• Phone: +61 2 8627 1185

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.