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Virtual exercise program to preserve function and prevent disability during chemotherapy

Distance-Based Exercise to Preserve Function and Prevent Disability

Not applicable Interventional Alliance for Clinical Trials in Oncology · NCT07059884

This trial tests whether supervised resistance sessions by video plus short home aerobic workouts help adults 18–64 maintain strength and stay active while receiving curative-intent chemotherapy.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment104 (estimated)
Ages18 Years and up
SexAll
SponsorAlliance for Clinical Trials in Oncology Academic / other
Drugs / interventionschemotherapy, immunotherapy, radiation
Locations17 sites (Dublin, California and 16 other locations)
Trial IDNCT07059884 on ClinicalTrials.gov

What this trial studies

This is a feasibility trial delivering a telehealth-based exercise program to adults undergoing outpatient cytotoxic chemotherapy with curative intent. Participants receive twice-weekly supervised resistance sessions via video with trained staff, unsupervised 30-minute aerobic sessions three times per week, adjustable dumbbells for home use, and continuous activity monitoring by accelerometer, continuing until chemotherapy completion or up to six months. Primary objectives are to establish implementation feasibility and to enroll and retain a diverse patient population, with exploratory outcomes including 6-minute walk distance, grip strength, accelerometer-measured activity, patient-reported outcomes, and employment status. The intervention is run at Kaiser Permanente sites in California and uses remote supervision to try to make exercise accessible during treatment.

Who should consider this trial

Good fit: Adults aged 18–64 who are initiating outpatient cytotoxic chemotherapy given with curative intent for solid tumors or hematologic malignancies and who can enroll on or before their second cycle are the intended participants.

Not a fit: Patients treated with immunotherapy/monoclonal antibodies only, those with progressive disease, significant mobility or safety limitations, inability to use video telehealth, or those outside the 18–64 age range are unlikely to be eligible or to benefit.

Why it matters

Potential benefit: If successful, this program could help patients preserve physical function, reduce treatment-related fatigue, and make exercising at home more practical during chemotherapy.

How similar studies have performed: Prior research has shown that exercise can reduce fatigue and help maintain function during cancer treatment, and telehealth delivery has shown promise though supervised remote resistance programs are less established.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Participants must have histologically confirmed cancer
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Participants must be initiating outpatient cytotoxic chemotherapy for curative intent (for any malignancy) of at least 10 weeks duration (with or without concurrent radiation, immunotherapy, or other targeted therapy). Patients must be enrolled and baseline measures collected on or before administration of their second cycle of cytotoxic therapy. Patients receiving outpatient cytotoxic chemotherapy for curative intent in the neoadjuvant or adjuvant setting for solid tumors are eligible. Patients receiving outpatient cytotoxic chemotherapy given for curative intent for hematologic malignancies, as well as patients receiving definitive chemoradiation for solid tumors, are also eligible. Regimens of immunotherapy or monoclonal antibodies ONLY are not eligible
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Age 18-64 years
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Patients cannot have metastatic cancer
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Patients cannot have documentation in the medical record of severe cardiovascular, respiratory or musculoskeletal disease or joint problems that preclude moderate physical activity. Examples would include unstable angina, recent myocardial infarction, oxygen-dependent pulmonary disease, and osteoarthritis requiring imminent joint replacement. Moderate arthritis that does not preclude physical activity is not a reason for ineligibility
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Patients cannot be pregnant, because this study involves remotely delivered exercise, and cannot be breast-feeding as patients must be receiving cytotoxic chemotherapy, during which breast-feeding is contraindicated
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Patients cannot have documentation in the medical record of current alcohol or substance abuse
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Engaged in full time gainful employment of at least 30 hours per week at the time of cancer diagnosis
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Currently no self-report of engagement in competitive sports (e.g. not training for running races, triathlons, etc) AND no self-report of twice weekly progressive resistance exercise training within the past year
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Self-reported ability to walk for 6 minutes (use of assistive devices will be allowed)
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Not participating in another weight loss, physical activity, or dietary intervention clinical trial
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Predicted 6MWT distance of 450 meters or less
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Concurrent enrollment in treatment or supportive care trials (other than those focused on weight loss or exercise) is allowed with the permission of the Alliance Executive Officer and both studies' study chairs
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Eligibility is restricted to individuals who can comprehend and read English given that participation in the study will require the ability to read intervention materials and work with a coach through telehealth sessions
* REGISTRATION ELIGIBILITY CRITERIA (STEP 1): The trial is unable to accommodate the needs of deaf or blind participants as the study relies on language and visualization of exercise through telehealth sessions
* CLINICAL STAKEHOLDER ELIGIBILITY CRITERIA: Clinicians and research staff from enrolling sites who meet following criterion will be deemed eligible to participate as a clinical stakeholder:

  \* Providing clinical care for participating patients on this study
* CLINICAL STAKEHOLDER ELIGIBILITY CRITERIA: Ability to speak and understand English

Exclusion Criteria:

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Where this trial is running

Dublin, California and 16 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.