Liver cancer prevention and care in Uganda using HIV clinic networks
Official title: Leveraging HIV care infrastructure for implementation of context-adapted liver cancer comprehensive control strategies in Uganda: The LC3 Study
Funded at Johns Hopkins University · NIH-11535354 · Data updated 2026-11-12
A program in Uganda uses existing HIV care systems to roll out liver cancer prevention, screening, and treatment strategies tailored to local needs.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 3, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $43,740 |
| NIH project number | 3U01CA275117-03S2 |
| Project ID | NIH-11535354 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults living with HIV in Uganda, particularly those in settings with high HBV/HCC burden.
✕Less likely to help
Patients who do not have HIV or HBV co-infection or who access care only outside the affected regions may see limited direct benefit.
What this research studies
This grant builds on long-running partnerships between Makerere and Johns Hopkins to implement context-adapted liver cancer prevention and care within HIV clinics in Uganda. It focuses on integrating HBV screening, diagnosis, vaccination, and HBV/HIV co-infection management into routine HIV care, with a strong emphasis on practical, real-world implementation. The approach uses a bundled set of interventions (the LC3 package) informed by local experience and evidence, and will assess how to deliver these services across diverse settings in Uganda. The work blends clinic-based activities with operational research to understand barriers and optimize delivery in both urban and rural regions.
Why it matters
Potential benefit: If successful, patients living with HIV in Uganda could receive earlier detection and better management of liver cancer risk.
How similar studies have gone: Previous implementation efforts have shown that integrating HBV services into HIV care is feasible and can improve care delivery in similar settings.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Kirk, Gregory D — Johns Hopkins University
- Study coordinator: Kirk, Gregory D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.