Condition

Liver Metastases clinical trials and research

• 51Clinical trials
• 11NIH research projects
• 21Countries

Newest Liver Metastases clinical trials

All recruiting trials (51)

• Prospective look at liver metastases imaging and tissue patterns in colorectal and breast cancer

  This observational study tests whether 3D maps of histopathological growth patterns in liver metastases align with imaging features from MRI/CT in patients undergoing liver surgery.

  Recruiting Cancer Research Antwerp · Wilrijk, Antwerp · NCT07781306

• Predicting liver failure after major liver surgery using CT measurements and vascular shape changes

  Doctors are testing whether adding vascular deformation mapping to CT measurements can better predict liver failure after removing a large portion of the liver.

  Recruiting at 3 sites Minia University · Minya, Minya Governorate and 2 other locations · NCT07727759

• DRAGON: International registry for patients who had combined portal and hepatic vein embolization before liver surgery

  This registry collects data on patients who had PVE/HVE before liver resection to see if it helps liver regeneration and what factors relate to outcomes.

  Recruiting at 30 sites Maastricht University Medical Center · Chicago, Illinois and 30 other locations · NCT07717437

• Metastatic liver cancer patient registry from multiple Chinese centers

  This is a registry that collects real-world data on adults with liver metastases to understand patterns and prognosis and to support future research.

  Recruiting at 2 sites Anhui Provincial Hospital · Bengbu, Anhui and 2 other locations · NCT07602504

• HEPZATO KIT with Opdualag for metastatic melanoma that has spread to the liver

  This will try adding HEPZATO KIT to Opdualag (nivolumab + relatlimab) to see if it's safe and helps people with metastatic melanoma that has spread to the liver.

  Recruiting Phase 1/2 University of Wisconsin, Madison · Madison, Wisconsin · NCT07281924

• Neoadjuvant immunotherapy with Dupilumab and Toripalimab for MSS colorectal cancer with resectable liver metastases

  This study tests a pre-surgery treatment combining dupilumab and toripalimab in adults with microsatellite-stable colorectal cancer that has liver metastases, to see if it’s safe and can lead to major tumor response.

  Recruiting Phase 1/2 Icahn School of Medicine at Mount Sinai · New York, New York · NCT07277322

• Boosting immunotherapy with low-dose liver radiation

  This trial tests whether adding low-dose radiation to the liver before immunotherapy helps people with melanoma or non-small cell lung cancer who have liver metastases live longer without their disease worsening.

  Recruiting University of Cincinnati · Cincinnati, Ohio · NCT07225036

• MRI-guided adaptive single-session radiation for liver tumors (SABR)

  This trial will test a single-session, MRI-guided adaptive high-dose radiation (SABR) for adults with primary or metastatic liver tumors to see if on-table MRI planning and replanning can treat tumors without a separate simulation visit.

  Recruiting Phase 2 Stanford University · Palo Alto, California · NCT07223307

• CRISPR-edited donor liver transplant to reduce rejection

  This trial will try transplanting deceased-donor livers that have had key HLA genes removed with CRISPR to see if they cause less rejection in adults needing a liver transplant.

  Recruiting Phase 1/2 American Organ Transplant and Cancer Research Institute LLC · Beijing, Changping · NCT07053488

• Histotripsy plus chemotherapy versus chemotherapy alone for colorectal cancer spread to the liver

  This trial will test whether adding noninvasive histotripsy to standard chemotherapy helps people with unresectable, liver‑confined colorectal cancer metastases stay free of disease progression longer.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT07044362

• Liver function after stereotactic body radiotherapy (SBRT)

  This project will use a special liver scan (HEBIS) before and after SBRT to see how different radiation doses affect liver function in people treated for liver metastases.

  Recruiting The Netherlands Cancer Institute · Amsterdam · NCT07033364

• Assessing blood biomarkers and MRI for liver cancer patients undergoing radiation therapy

  This study is testing if using special MRI scans and blood tests can help doctors keep track of liver health in patients with liver cancer who are getting radiation therapy.

  Recruiting Montefiore Medical Center · The Bronx, New York · NCT06899152

• Treatment for liver metastases from colorectal cancer using a combination of therapies

  This study is testing if a new combination of treatments for liver cancer from colorectal cancer can help patients live longer compared to the standard treatment they would usually receive.

  Recruiting Phase 3 The Netherlands Cancer Institute · Amsterdam · NCT06857773

• Combining radiation therapy and PD-1 antibody for liver metastases from colorectal cancer

  This study is testing if combining a special type of radiation therapy with a new immune treatment can help people with liver cancer from colorectal cancer feel better and live longer.

  Recruiting Phase 3 Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT06794086

• Evaluating a new immuno-adjuvant for colorectal liver metastases after ablation treatments

  This study is testing a new treatment called IP-001 to see if it can boost the immune response and help people with colorectal liver metastases feel better after they have undergone ablation therapies.

  Recruiting Phase 1/2 Amsterdam UMC, location VUmc · Amsterdam, North Holland · NCT06630624

• Combination treatment for liver metastases from uveal melanoma

  This study is testing a new combination treatment for patients with liver metastases from uveal melanoma to see if adding a special delivery method can help them live longer without their cancer getting worse.

  Recruiting at 3 sites Phase 3 Vastra Gotaland Region · Gothenburg and 5 other locations · NCT06519266

• Ultra-high dose MR-guided single-session radiation for liver metastases

  This trial will test whether one very high‑dose MR‑guided radiation session works better than a high‑dose approach for adults with up to three liver metastases.

  Recruiting Phase 3 University Health Network, Toronto · Toronto, Ontario · NCT06362395

• Testing immunotherapy combinations for colorectal cancer that has spread to the liver

  This study is testing different combinations of immunotherapy treatments for people with colorectal cancer that has spread to the liver to see if they can improve treatment results before surgery.

  Recruiting Phase 2 Weill Medical College of Cornell University · New York, New York · NCT06300463

• ctDNA blood tests to guide treatment in colorectal cancer with liver metastases

  A study using blood tests that look for tumor DNA to help decide which patients with colorectal cancer that has spread to the liver need more treatment after surgery.

  Recruiting at 2 sites University Hospital, Montpellier · Montpellier and 1 other locations · NCT06287723

• Combining Serplulimab and Bevacizumab with FOLFOX for Colorectal Cancer Treatment

  This study is testing if adding two new drugs to standard chemotherapy can help people with colorectal cancer that has spread to the liver live longer and have fewer chances of the cancer coming back after surgery.

  Recruiting Phase 2/3 Sun Yat-sen University · Guangzhou, Guangdong · NCT06280495

• Comparing simultaneous and staged surgery for colorectal cancer with liver metastases

  This study is testing whether doing surgery for colon cancer and liver tumors at the same time or in separate stages is better for patients in terms of recovery and overall health.

  Recruiting Oslo University Hospital · Oslo · NCT06200831

• Comparing two treatments for colorectal liver metastases

  This study is testing whether a new treatment called irreversible electroporation works better than stereotactic body radiotherapy for people with hard-to-treat colorectal cancer that has spread to the liver.

  Recruiting Phase 2/3 Amsterdam UMC, location VUmc · Amsterdam, North Holland · NCT06185556

• Using AI to improve treatment for liver tumors

  This study is testing whether using artificial intelligence can help doctors choose the best treatments and predict outcomes for patients with liver tumors undergoing thermal ablation.

  Recruiting Leiden University Medical Center · Leiden · NCT06179602

• High-dose MRI-guided radiation therapy for liver cancer from colorectal cancer

  This study is testing if a single high-dose radiation treatment guided by MRI can help people with liver cancer caused by colorectal cancer by stopping the growth of tumors and seeing how well it works based on MRI images.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT06130280

• Comparing surgery and medical treatment for breast cancer that has spread to the liver

  This study is testing whether surgery or just medical treatment works better for people with breast cancer that has spread to the liver.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Rome, Lazio · NCT06093022

• Comparing methods to increase liver size before surgery

  This study is testing three different ways to help increase liver size before surgery for patients with liver tumors to see which method works best.

  Recruiting Medical University of Warsaw · Warsaw, Masovian Voivodeship · NCT06050200

• Neoadjuvant therapy followed by local treatment for recurrent colorectal liver metastases

  This study is testing if giving a new treatment before local therapy can help people with recurrent colorectal liver cancer live longer compared to getting local therapy right away.

  Recruiting Phase 3 Amsterdam UMC, location VUmc · Amsterdam · NCT05861505

• Using Alpha Radiation to Treat Liver Metastases

  This study is testing a new treatment using alpha radiation to see if it can safely target and shrink liver tumors in patients with liver metastases.

  Recruiting Alpha Tau Medical LTD. · Montreal, Quebec · NCT05829291

• Comparing chemotherapy and observation for liver metastasis in colorectal cancer

  This study is testing if some patients with liver metastasis from colorectal cancer can safely skip chemotherapy after surgery and just be monitored instead.

  Recruiting Phase 3 Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT05815082

• Maintenance therapy for colorectal cancer patients after liver surgery

  This study is testing if adding maintenance therapy to standard chemotherapy can help colorectal cancer patients with liver metastases live longer without their cancer getting worse after surgery.

  Recruiting Phase 3 Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT05797077

• Improving recovery after surgery with intravenous iron treatment

  This study tests if giving intravenous iron to patients who lose a lot of blood during major surgeries can help them recover better and need fewer blood transfusions.

  Recruiting Phase 3 Uppsala University Hospital · Uppsala, Sverige · NCT05744219

• Combining Bevacizumab with Chemoimmunotherapy for Advanced Lung Cancer with Liver Metastases

  This study is testing whether adding a drug called bevacizumab to a combination of chemotherapy and another treatment can help people with advanced lung cancer that has spread to the liver live longer and feel better.

  Recruiting at 3 sites Phase 2 Cedars-Sinai Medical Center · Los Angeles, California and 2 other locations · NCT05588388

• Using MRI to Improve Surgery Selection for Pancreatic Cancer Patients

  This study is testing whether using MRI along with CT scans can help doctors better decide if surgery is a good option for pancreatic cancer patients with possible liver spread.

  Recruiting at 3 sites University of Aarhus · Aalborg and 2 other locations · NCT05428358

• Liver transplantation for patients with non-resectable colorectal liver metastases

  This study is testing whether liver transplantation can help patients with colorectal cancer that has spread to the liver when surgery isn't an option.

  Recruiting Hospital Vall d'Hebron · Barcelona, Barcelona · NCT05398380

• Using ctDNA to guide chemotherapy after liver surgery for colorectal cancer

  This study is testing if checking for tumor DNA in the blood after liver surgery for colorectal cancer can help doctors decide the best follow-up treatment for patients to prevent the cancer from coming back.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT05062317

• Cryoablation with Sintilimab and Regorafenib for Liver Metastases from Colorectal Cancer

  This study is testing if combining a freezing treatment with two medications can help people with liver cancer from colorectal cancer who haven't responded to previous treatments.

  Recruiting Phase 2 Fudan University · Shanghai, Shanghai Municipality · NCT05057052

• Neoantigen vaccine combined with nivolumab for liver cancer treatment

  This study is testing a personalized vaccine combined with a cancer drug to see if it can help people with liver cancer stay cancer-free after surgery.

  Recruiting Phase 2 National Cancer Centre, Singapore · Singapore · NCT04912765

• Intra-arterial liver infusion of radiolabeled somatostatin drugs for gastroenteropancreatic neuroendocrine tumors with dominant liver metastases

  This will test whether giving radiolabeled somatostatin medication directly into the liver works better than the usual IV route for people with gastroenteropancreatic neuroendocrine tumors whose disease mainly affects the liver after four Lutathera treatments.

  Recruiting Phase 2 University Hospital, Bordeaux · Bordeaux and 3 other locations · NCT04837885

• Comparing standard and guided radiation therapy for liver cancer

  This study is testing if a new way of guiding radiation therapy can help people with liver cancer get better results and less damage to healthy tissue compared to the standard method.

  Recruiting London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario · NCT04745390

• Treatment for colorectal cancer patients with liver metastases that can't be surgically removed

  This study is testing two different treatment combinations to see which one helps colorectal cancer patients with liver tumors that can’t be removed by surgery live longer and possibly make their tumors operable.

  Recruiting Phase 3 Fudan University · Shanghai, Shanghai Municipality · NCT04687631

• Liver transplantation for patients with colorectal cancer that has spread to the liver

  This study looks at whether liver transplants can help patients with colorectal cancer that has spread only to the liver live longer if their cancer was well-controlled by chemotherapy before the transplant.

  Recruiting Hospital Universitario La Fe · Valencia · NCT04616495

• Improving fitness during chemotherapy for liver cancer patients

  This study is testing a 16-week program that combines exercise, nutrition, and support to see if it helps liver cancer patients feel fitter during chemotherapy and before surgery compared to those who only get support right before surgery.

  Recruiting Institut Investigacio Sanitaria Pere Virgili · Tarragona · NCT04520737

• Analyzing liver tumor tissue after ablation to guide further treatment

  This study is testing if looking at liver tumor samples after treatment can help doctors decide the best next steps for patients with liver cancer.

  Recruiting Phase 2/3 Memorial Sloan Kettering Cancer Center · New York, New York · NCT04143516

• Using MRI to guide radiation therapy for various cancers

  This study is testing if using MRI scans to adjust radiation therapy can help people with different types of cancer, like pancreatic and lung cancer, feel better and control their tumors more effectively.

  Recruiting at 2 sites Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT04115254

• Local treatment for breast cancer that has spread to the liver

  This study is testing whether surgery for liver cancer that has spread from breast cancer can help patients live longer and feel better compared to regular treatments.

  Recruiting Phase 3 Umeå University · Umeå · NCT04079049

• Evaluating the impact of MR-guided radiation therapy on cancer treatment outcomes

  This study is testing how using a special type of radiation therapy with real-time imaging can improve treatment results and quality of life for adults with cancer.

  Recruiting at 14 sites UMC Utrecht · Pittsburgh, Pennsylvania and 17 other locations · NCT04075305

• MRI‑guided, dose‑escalated SBRT for liver and nearby bowel metastases

  This trial will try giving higher, MRI‑guided stereotactic radiation doses to people with liver or adjacent bowel metastases to find the safest maximum dose.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT04020276

• Comparing liver transplantation to chemotherapy for colorectal cancer patients with liver metastases

  This study is testing whether liver transplantation works better than chemotherapy for colorectal cancer patients whose liver cancer can't be surgically removed.

  Recruiting Oslo University Hospital · Oslo · NCT03494946

• Liver transplantation for patients with colorectal cancer liver metastases

  This study is testing a new approach that combines surgery and liver transplantation to see if it can help patients with colorectal cancer that has spread to the liver live longer compared to standard chemotherapy.

  Recruiting at 2 sites Jena University Hospital · Jena and 1 other locations · NCT03488953

• Using targeted radiation therapy for liver tumors that can't be surgically removed

  This study is testing if a special type of radiation therapy can help patients with certain types of cancer who have liver tumors that can't be surgically removed.

  Recruiting Phase 2 University of Sao Paulo · São Paulo, São Paulo · NCT02185443

• Using proton therapy to treat liver metastases

  This study is testing if proton therapy can help control hard-to-treat liver metastases better than traditional methods for patients who have limited treatment options.

  Recruiting Loma Linda University · Loma Linda, California · NCT01697371

NIH-funded research (11)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• TREM2+ macrophages and liver metastases in pancreatic cancer

  Researchers are studying immune cells in liver metastases from pancreatic cancer to understand how they influence the cancer’s spread and more effective treatments.

  NIH research Washington University · Saint Louis, United States · NIH-11452084

• Immune regulation in colon cancer and its spread to lymph nodes and liver

  A patient-friendly look at how immune system circuits in colorectal cancer and its metastases may influence treatment responses and outcomes.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11415153

• Ablating Liver Metastases with SBRT to Boost Immunotherapy in Melanoma

  Aims to see if targeted liver radiation plus two immunotherapy drugs helps people with melanoma that has spread to the liver.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11393641

• Targeting stress defenses in eye melanoma that spreads to the liver

  Researchers are working to weaken tumor cells' defenses against oxidative damage so liver metastases from uveal (eye) melanoma in adults become more vulnerable to treatment.

  NIH research Drexel University · Philadelphia, United States · NIH-11298994

• Exercise before liver surgery to lower colorectal cancer recurrence

  Exercise before liver surgery aims to calm harmful immune responses and reduce the chance colorectal cancer comes back in the liver for people with liver metastases.

  NIH research University of Virginia · Charlottesville, United States · NIH-11289466

• Immune cell circuits in primary colon tumors and their lymph node and liver metastases

  This project looks at how immune cells and their neighborhoods behave in people with the common pMMR form of colon cancer to find ways to make immunotherapy work better.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11176073

• Exploring how surgery affects the immune response and liver cancer spread

  This study is looking at how exercise before surgery can help people with colorectal cancer that has spread to the liver by boosting their immune system and reducing inflammation, which might lead to better recovery and lower chances of cancer coming back.

  NIH research University of Virginia · Charlottesville, United States · NIH-11075861

• Understanding how liver conditions affect uveal melanoma spread

  This study is looking at how uveal melanoma, a serious eye cancer that can spread to the liver, grows in that environment, with the hope of finding new treatments to help patients live longer and better.

  NIH research Drexel University · Philadelphia, United States · NIH-11061803

• Understanding immune interactions in colon cancer and its spread to lymph nodes and liver

  This study is looking at how certain immune cells behave in colon cancer and its spread to lymph nodes and the liver, to help understand why some patients don’t respond well to treatments, and it’s for people with colorectal cancer.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-10911894

• Improving MRI technology to detect liver tumors earlier

  This study is working on improving MRI scans to help doctors find small liver tumors in people with colorectal cancer more easily, which could lead to quicker and better treatment options for patients.

  NIH research University of Arizona · Tucson, United States · NIH-10755679

• Identifying imaging markers to predict treatment response and recurrence in colorectal liver cancer

  This study is looking to find new ways to use regular CT scans to help predict how well patients with colorectal liver cancer will respond to treatment and their chances of the cancer coming back, so that doctors can tailor treatments to each person's needs.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-10684268

Related topics

Quick answers

How many Liver Metastases clinical trials are recruiting right now?

51, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 21 countries. The most sites are in United States (16 trials), Netherlands (8 trials), China (8 trials), Canada (5 trials), Spain (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 10, Phase 2: 9, Phase 1/2: 4, Phase 2/3: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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