Exploring the links between cancer, undernutrition, and sensory changes
Oncology, Undernutrition and Sensoriality: Links, Mechanisms and Levers for Action - Study ONDES
This study looks at how newly diagnosed cancers in the mouth, throat, colon, and liver affect patients' nutrition and senses like taste and smell, to see how these changes impact their eating habits and quality of life.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 306 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire Dijon Academic / other |
| Drugs / interventions | chemotherapy, immunotherapy |
| Locations | 1 site (Dijon) |
| Trial ID | NCT06600295 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the connections between newly diagnosed cancers of the oropharynx, oral cavity, colon, and liver, and the issues of undernutrition and sensory changes such as taste and smell. It aims to understand how these factors affect patients' dietary habits and overall quality of life. Participants will undergo various assessments, including tests, questionnaires, and biological sample evaluations, to gather comprehensive data on their nutritional status and sensory experiences. The study seeks to identify mechanisms and potential interventions to improve patient outcomes.
Who should consider this trial
Good fit: Ideal candidates are adults with newly diagnosed cancer of the oropharynx, oral cavity, colon, or liver who are able to participate in the study procedures.
Not a fit: Patients who are unable to provide informed consent or have pre-existing sensory disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved nutritional support and quality of life for cancer patients facing undernutrition.
How similar studies have performed: While there is ongoing research into the nutritional needs of cancer patients, this specific focus on sensory changes and undernutrition in these cancer types is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Patient : * With newly diagnosed cancer of the oropharynx, oral cavity, colon or liver (at any stage). * For whom first-line treatment has been decided including radiotherapy, chemotherapy, immunotherapy and/or surgery. * Able to follow all study procedures in accordance with the protocol. * Have given their oral, free and informed consent to participate in the study. Exclusion Criteria: * Person not affiliated with national health insurance system * Person subject to a legal protection measure (curatorship, guardianship) * Pregnant women, women in labour or breastfeeding mothers * Adults who is unable to give consent * Minors * Person unable to read, speak, write and understand French * Patients with neuro-cognitive disorders (post-stroke, dyslexia, dyspraxia) or neuro-psychiatric disorders (dementia, autism) that make it impossible to assess taste sensoriality. * Patients with olfactory or gustatory disorders documented prior to the disease * Patient with another cancer currently being treated * Patients with a systemic disease or physical trauma affecting taste perception * Patients with kidney failure * Patients with sinonasal polyposis * Patients undergoing immunosuppressive treatment * Patients with an estimated life expectancy of less than 3 months
Where this trial is running
Dijon
- Chu Dijon Bourgogne — Dijon, France (Recruiting)
Study contacts
- Study coordinator: Vanessa COTTET
- Email: Vanessa.cottet@u-bourgogne.fr
- Phone: 0380393487
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.