Using advanced ultrasound techniques to improve liver cancer diagnosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to enhance the diagnosis of hepatocellular carcinoma (HCC) by employing innovative quantitative ultrasound (QUS) techniques that assess tumor viscoelasticity and tissue structure. The researchers hypothesize that these advanced imaging methods, combined with machine learning classification models, will significantly improve the sensitivity and specificity of liver cancer detection compared to standard ultrasound. The study will involve patients with focal liver lesions visible during ultrasound screening, who are either enrolled in a monitoring program or referred for characterization. By improving early detection rates, the study seeks to increase the number of patients eligible for curative treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Are at least 18 years old at screening;
* Able to comprehend and willingness to provide voluntary consent;
* Are able to have a MRI;
* Understand French or English;
* Patients enrolled in a monitoring program or referred for the characterization of a focal liver lesion;
* Focal liver lesion is visible during ultrasound screening in B-mode.

Exclusion Criteria:

* Are pregnant or trying to become pregnant;
* Have a weight or girth preventing from entering the MR magnet bore;
* Are unable to understand or unwilling to provide written informed consent for this study;
* Have a contraindication to MRI (pacemaker, insurmountable claustrophobia);
* Have chronic kidney disease preventing the injection of gadolinium-based contrast agent.

Where it's running

• Centre hospitalier de l'Université de Montréal (CHUM)
  Montreal, Quebec, Canada Recruiting

Study contacts

• Principal investigator: Guy Cloutier, PhD — Centre hospitalier de l'Université de Montréal (CHUM)
• Study coordinator: Guy Cloutier, PhD
• Email: guy.cloutier@umontreal.ca
• Phone: 514-890-8000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.