Creating biological models to study liver diseases and tumors
"Constitution of a Biological Collection to Establish Preclinical Translational Models for the Study of Tumors and Chronic Liver Diseases".
This study is trying to create new models to better understand liver diseases and tumors so that we can find better treatments for people suffering from these conditions.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 800 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Institut National de la Santé Et de la Recherche Médicale, France Government |
| Locations | 1 site (Strasbourg) |
| Trial ID | NCT04690972 on ClinicalTrials.gov |
What this trial studies
This study focuses on developing preclinical translational models to better understand chronic liver diseases and tumors, including non-alcoholic steatohepatitis and liver cancer. The research involves collecting blood samples and biopsies from patients undergoing surgery or diagnostic tests to analyze the liver's microenvironment and disease mechanisms. By utilizing advanced techniques like single cell RNA sequencing, the study aims to identify new therapeutic targets and improve treatment responses for these conditions. The ultimate goal is to enhance the understanding of liver diseases and facilitate the development of effective therapies.
Who should consider this trial
Good fit: Ideal candidates for this study are adults diagnosed with chronic liver disease and at least one liver nodule requiring a biopsy.
Not a fit: Patients who are minors, under legal protection, or unable to provide informed consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and better outcomes for patients with chronic liver diseases and liver cancer.
How similar studies have performed: While similar studies have explored liver disease models, this approach utilizing single cell RNA sequencing represents a novel and advanced methodology.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients * diagnosed with chronic liver disease (viral or not) * diagnosed with at least one liver nodule for which a biopsy is planned as part of the care * for hepatobiliary surgery planned as part of care * for locoregional treatment for HCC is indicated 2. Patients able to receive and understand information relating to the study and give their written informed consent 3. Patients affiliated to the French social security system Exclusion Criteria: 1. Minor patients 2. Patients under legal protection, 3. Patients subject to legal protection or unable to express their consent, 4. Patients in a situation of social fragility, 5. Pregnant or breastfeeding woman, 6. No signing of informed consent.
Where this trial is running
Strasbourg
- PU-PH, Directeur de l'UMR_S1110 Unité Inserm d'affiliation : UMR_S1110 — Strasbourg, France (Recruiting)
Study contacts
- Study coordinator: Thomas BAUMERT, DR
- Email: thomas.baumert@unistra.fr
- Phone: 03 68 85 37 03
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.