Condition

Insomnia clinical trials and research

• 147Clinical trials
• 101NIH research projects
• 3New in 30 days
• 25Countries

Newest Insomnia clinical trials

All recruiting trials (147)

• SleepCogni for children with chronic insomnia

  A handheld SleepCogni device is tested to see if it helps kids aged 6–16 with chronic insomnia sleep better.

  Recruiting Sheffield Children's NHS Foundation Trust · Sheffield · NCT07926724

• Music therapy after stroke

  This trial tests whether adding music therapy to standard care helps stroke patients sleep better and feel less anxious or depressed while in the hospital.

  Recruiting Universidad de Granada · Granada, Granada · NCT07899034

• Remote ischemic conditioning for post-stroke insomnia

  A 136-person, randomized study will test whether a non-invasive arm-cuff procedure done twice daily for 90 days can improve sleep after a first ischemic stroke in adults 18–80.

  Recruiting Sichuan Academy of Medical Sciences · Chengdu, Sichuan · NCT07874594

• Nurse-guided app-based brief behavioral therapy for insomnia in older adults

  Aging adults with insomnia will be asked to try a nurse-supported, smartphone app therapy for four weeks to see if it helps with sleep.

  Recruiting Taipei Medical University · Taipei · NCT07842250

• Three rTMS approaches to lessen insomnia-related pain after exercise-induced muscle soreness

  This study tests whether three different rTMS approaches can reduce pain sensitivity and improve recovery in adults with insomnia after inducing muscle soreness from exercise.

  Recruiting The Hong Kong Polytechnic University · Hong Kong · NCT07827677

• Insomnia and Sleep Disruption's Effect on Pain Sensitivity and Muscle Soreness After Exercise

  This study tests whether poor sleep or insomnia affects how people feel pain and recover from exercise-induced muscle soreness in healthy adults.

  Recruiting The Hong Kong Polytechnic University · Hong Kong · NCT07827664

• Acute Muscle Pain and Sleep in Insomnia vs. Healthy Sleepers

  This study tests how temporary muscle soreness after intense exercise affects sleep in people with insomnia compared to healthy adults.

  Recruiting The Hong Kong Polytechnic University · Hong Kong · NCT07826650

• Sleep and arterial function in hypertensive patients with poor sleep quality

  This trial tests whether using cognitive-behavioural therapy for insomnia can improve artery health and well-being in adults with high blood pressure and poor sleep.

  Recruiting Unidade Local de Saúde do Alto Ave, EPE · Guimarães, Braga District · NCT07789535

• Managing nighttime voiding in older women with sleep strategies

  This study tests whether brief behavioral sleep therapy and mindfulness, alone or together, reduce how often older women wake at night to urinate and how much urine they produce at night.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07760779

• Managing COMISA: adding daridorexant to CPAP may help sleep and CPAP use

  This study tests whether adding daridorexant to CPAP helps people with COMISA better stick with CPAP and feel better.

  Recruiting University Hospital, Grenoble · Grenoble and 4 other locations · NCT07743931

• Chaihushugan Decoction vs Wen Dan Tang for Chronic Insomnia

  This trial tests two traditional Chinese medicine formulas to see if one helps adults with chronic insomnia more than the other over 8 weeks.

  Recruiting Tainan Hospital, Ministry of Health and Welfare · Tainan · NCT07735390

• Insomnia and Post-Dental Surgery Pain: A Look at Sleep Quality and Pain After Tooth Extractions

  This study tests whether preoperative sleep problems influence how much pain people feel after routine tooth extractions.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma · NCT07712432

• Understanding how GIM residents’ well-being relates to their careers over time

  This study tests how burnout, depression, sleep problems, stress, and fatigue among general internal medicine residents relate to their future career paths.

  Recruiting at 3 sites University of Fribourg · Bern and 2 other locations · NCT07707453

• CBT-I with Melatonin for Older Adults with Chronic Insomnia

  In people aged 60 and over with chronic insomnia, researchers will test whether CBT-I plus nightly melatonin helps sleep better than CBT-I with a placebo or sleep-health education with placebo.

  Recruiting The University of Hong Kong · Hong Kong · NCT07695246

• Does Yoga Style Affect Sleep and Heart Health in Adults with and without Insomnia

  This study tests whether two styles of yoga (vinyasa and gentle yoga) done in the evening can improve sleep and heart health in adults, including those with insomnia.

  Recruiting University of Central Florida · Orlando, Florida · NCT07638267

• CBT-I for insomnia in physically active adults

  A 6-week program of Cognitive Behavioral Therapy for Insomnia is being tested to see if it can help people who exercise regularly and have bothersome insomnia.

  Recruiting Federal University of Jatai · Jatai, Goiás · NCT07607444

• Digital therapy BELL-001 to help with insomnia

  A smartphone-based therapy called BELL-001 is being tried in adults with insomnia to see if it is safe and helps people fall asleep and stay asleep over about 3 months.

  Recruiting at 3 sites BELL Therapeutics Inc. · Incheon and 2 other locations · NCT07582809

• Sleep and Recovery After Stroke

  This study will test whether wearable devices and overnight breathing recordings can find sleep problems like sleep apnea and show how those problems affect people three months after an ischemic stroke.

  Recruiting Region Skane · Lund, Skåne County · NCT07579871

• Auricular Laser Acupuncture for Sleep in Breast Cancer Patients

  This trial tests whether active auricular laser acupuncture can improve sleep in women with breast cancer and insomnia compared with a sham laser.

  Recruiting Chung Shan Medical University · Taichung · NCT07547423

• A smart look at common sleep meds for insomnia

  This trial tests how well and how safely widely used sleep medicines and OTCs work for adults with insomnia and which might be best overall.

  Recruiting Phase 4 University of Pennsylvania · Philadelphia, Pennsylvania · NCT07542756

• Comparing exercise, cognitive behavioral therapy for insomnia, and both for chronic musculoskeletal pain with poor sleep

  This project will test whether a 12-month home-based exercise program, CBT for insomnia, or their combination helps reduce pain and improve sleep in adults with chronic low back pain or hip/knee osteoarthritis who have poor sleep.

  Recruiting University of Sydney · San Antonio, Nevada and 3 other locations · NCT07532070

• Wearable, voice-guided BBTi for COMISA (insomnia + sleep apnea)

  A wearable, voice-guided Brief Behavioral Therapy for Insomnia (BBTi) combined with a smart eye-mask is being tested to see if it helps adults with COMISA improve sleep and CPAP adherence.

  Recruiting National Sun Yat-sen University · Tainan, Taiwan · NCT07521319

• Ear acupressure for functional dyspepsia with insomnia

  This trial will test whether pressing specific points on the ear can reduce bothersome upper‑abdominal dyspepsia symptoms and improve sleep in adults with functional dyspepsia and insomnia.

  Recruiting The First Affiliated Hospital of Zhejiang Chinese Medical University · Hangzhou, Zhejiang · NCT07442734

• Parent-led sleep program for insomnia in young autistic children

  This trial tests whether a parent-delivered Sleep Parent Treatment (SPT) helps improve sleep for autistic kids aged 3 to almost 8 years, compared with Sleep Parent Education (SPE), over 10 weeks.

  Recruiting at 3 sites The Cleveland Clinic · Cleveland, Ohio and 2 other locations · NCT07435740

• Blue-blocking glasses for sleep problems in children and teens

  This study tests whether wearing blue-blocking glasses or using real darkness at night helps sleep problems in children and adolescents with insomnia or delayed sleep phase disorder who are receiving mental health care.

  Recruiting Helse Fonna · Haugesund, Rogaland and 1 other locations · NCT07433491

• Telehealth CBT for insomnia tailored to ulcerative colitis

  This pilot will test whether telehealth cognitive behavioral therapy for insomnia, adapted for adults with ulcerative colitis, can improve sleep and is acceptable to patients.

  Recruiting Dartmouth-Hitchcock Medical Center · Lebanon, New Hampshire · NCT07428629

• APSTZD for Insomnia: Safety and Effectiveness in Adults

  This trial tests APSTZD against an active drug and placebo to see if it helps adults with insomnia.

  Recruiting Phase 2 Apsen Farmaceutica S.A. · Bragança Paulista, São Paulo · NCT07420816

• Lemborexant for insomnia in people with psychiatric conditions

  We will try lemborexant for 8 weeks in adults with psychiatric disorders who have insomnia to see if it helps them sleep better and is safe.

  Recruiting at 9 sites Shanghai Mental Health Center · Suzhou, Jiangsu and 8 other locations · NCT07417813

• SleepFix for Youth: Digital Therapy for Insomnia With E-Psychologist Support

  A pilot study tests SleepFix, a smartphone-based digital therapy for insomnia with weekly support from an e-psychologist, in young people aged 16-24 to see if it helps sleep more than an online sleep-education comparison.

  Recruiting Woolcock Institute of Medical Research · Sydney, New South Wales · NCT07405775

• CBT for insomnia to reduce impulsivity and risky behavior in young people

  This project will test whether group cognitive behavioral therapy for insomnia (CBT-I) can reduce impulsive behavior and risky decision-making in Chinese youths aged 12–24 who have insomnia.

  Recruiting The University of Hong Kong · Hong Kong · NCT07399964

• An app-based program to help children with ASD and insomnia sleep better

  This project will test whether an app-based, parent-led sleep program—with or without phone support—helps children aged 6–12 with ASD and insomnia and also improves parental sleep and stress.

  Recruiting The University of Hong Kong · Hong Kong · NCT07398183

• Understanding the Locus Coeruleus in Insomnia

  This study tests whether a brain chemical blocker (dexmedetomidine) or placebo can reveal how the locus coeruleus relates to insomnia in adults.

  Recruiting Phase 2 Woolcock Institute of Medical Research · Macquarie Park, New South Wales · NCT07392177

• Intelligent app-based diagnosis and treatment program for insomnia

  This trial will try an intelligent, app-delivered cognitive behavioral therapy program to help adults with insomnia sleep better and reduce treatment costs.

  Recruiting The First Hospital of Jilin University · Changchun, Jilin · NCT07357779

• Tailored behavioral programs to improve sleep in first-time mothers

  This study tests whether a person-centered behavioral sleep program or a guided aerobic exercise program helps first-time mothers 4–12 months after delivery with insomnia sleep better than usual postpartum care.

  Recruiting at 2 sites Research Foundation - Flanders (Fonds Wetenschappelijk Onderzoek) · Brussels, Jette and 1 other locations · NCT07345065

• See if CBT-I can help with insulin resistance in adults with insomnia

  This study tests whether Cognitive Behavioral Therapy for Insomnia (CBT-I) can improve insulin resistance and metabolic measures in adults with insomnia.

  Recruiting University of Missouri-Columbia · Columbia, Missouri · NCT07333586

• 40 Hz flicker light for sleep in Parkinson’s disease

  A small study tests whether 40 Hz flickering light at bedtime helps people with Parkinson’s and insomnia see if it improves their sleep.

  Recruiting Jiangsu Province Nanjing Brain Hospital · Nanjing, Jiangsu · NCT07323121

• Remote CBT-I with IoT and AI for Insomnia in Older Adults

  This trial tests if a fully remote, AI‑driven digital CBT‑I program with IoT environmental cues helps older adults with insomnia more than two active CBT‑I–based or sleep hygiene controls.

  Recruiting at 2 sites Phase 2 Proactive Life Inc · New York, New York and 1 other locations · NCT07316153

• Sleep-hygiene education to improve sleep quality and mood in menopausal women.

  This trial will try sleep-hygiene education based on the IMB model to see if it improves sleep quality and reduces depressive symptoms in menopausal women with poor sleep.

  Recruiting Ankara Yildirim Beyazıt University · Ankara · NCT07299903

• Remote ischemic conditioning to help sleep in Parkinson’s disease

  A small, randomized study will test if brief, controlled limb ischemia over 7 days can improve sleep and other non-motor symptoms in people with Parkinson’s and insomnia.

  Recruiting Jiangsu Province Nanjing Brain Hospital · Nanjing, Jiangsu · NCT07299240

• Boosting resilience and reducing chronic low back pain by treating sleep and adding meditation or pain education

  This program tests whether adding savoring meditation or extra pain education to a cognitive behavioral sleep program helps adults with chronic low back pain and insomnia have less pain.

  Recruiting Phase 2 University of Virginia · Charlottesville, Virginia · NCT07298941

• How insomnia develops during the first year after a new cancer diagnosis

  This project will track how insomnia appears and changes during the first year after a cancer diagnosis in adults who had no prior sleep problems.

  Recruiting Centre Hospitalier Emile Roux · Le Puy-en-Velay · NCT07280416

• Phone-delivered healthy behavior programs to prevent insomnia in people with HIV with chronic pain

  This test compares brief phone-delivered behavioral insomnia treatment versus brief phone-delivered mindfulness training to see if they reduce insomnia, ease chronic pain, and slow biological aging in adults with HIV who have ongoing pain.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT07270406

• Noninvasive ear vagus nerve stimulation for insomnia in adult survivors of childhood ALL

  This tests whether nightly noninvasive ear vagus nerve stimulation can improve sleep in adult survivors of childhood acute lymphoblastic leukemia who have moderate to severe insomnia.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07191119

• Special blankets to improve sleep for 16–24-year-olds

  This project will test whether special tactile or weighted blankets help 16–24‑year‑olds with insomnia sleep better.

  Recruiting Aarhus University Hospital · Aarhus · NCT07181577

• How insomnia affects PAP use in children and teens with obstructive sleep apnea.

  This study will see if insomnia makes children and teens with obstructive sleep apnea less likely to stick with positive airway pressure (PAP) therapy.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT07176767

• Digital CBT versus nightly trazodone versus nightly daridorexant for menopause-related insomnia

  This project will see if online cognitive behavioral therapy, nightly trazodone, or nightly daridorexant helps people in peri- and post-menopause who are having insomnia.

  Recruiting at 4 sites Phase 4 Brigham and Women's Hospital · Boston, Massachusetts and 4 other locations · NCT07136415

• Web-based insomnia treatment for Black prostate cancer survivors

  This project will test whether an online cognitive behavioral therapy program called SHUTi helps Black prostate cancer survivors with insomnia compared with an online educational website.

  Recruiting Georgetown University · Washington D.C., District of Columbia · NCT07128927

• Early restorative sleep treatment after an emergency department visit

  This trial will try virtual cognitive behavioral therapy for insomnia and nightmares soon after an assault-related emergency visit to see if it improves sleep and reduces PTSD symptoms.

  Recruiting Henry Ford Health System · Detroit, Michigan · NCT07121270

• Smartphone CBT‑I app for insomnia in cancer survivors

  This project will test whether the iCANSleep smartphone app reduces insomnia symptoms in Canadian adults who have completed cancer treatment.

  Recruiting Memorial University of Newfoundland · St. John's, Newfoundland and Labrador · NCT07101302

• Cognitive behavioral therapy for insomnia in adults with type 1 diabetes

  This trial will test whether virtual cognitive behavioral therapy for insomnia (CBT-I) helps adults with type 1 diabetes sleep better and improves blood sugar control and quality of life.

  Recruiting Early Phase 1 University of Illinois Chicago · Chicago, Illinois · NCT07091318

• NiteCAPP Jr: a digital CBT sleep program for kids aged 6–12 with insomnia

  This will test whether a digital cognitive behavioral therapy program called NiteCAPP Jr, delivered with caregiver support, can help children aged 6–12 who have insomnia compared with being on a waitlist.

  Recruiting University of South Florida · Tampa, Florida · NCT07091149

• Cystic Fibrosis Wellness Program for Adults with Fatigue

  This pilot randomized trial will try a combined cognitive behavioral therapy and physical activity coaching program to see if it helps adults with cystic fibrosis who have significant fatigue sleep better, move more, and sit less.

  Recruiting Johns Hopkins University · Denver, Colorado and 2 other locations · NCT07071324

• Accelerated 5-day program for insomnia, nightmares, and PTSD

  This 5-day group program combines cognitive-behavioral therapy for insomnia and nightmares with written exposure therapy to see if it reduces sleep problems and PTSD symptoms in active-duty military members and veterans who have insomnia, nightmares, and PTSD.

  Recruiting Palo Alto Veterans Institute for Research · Kileen, Texas · NCT07069517

• Improving diabetes care by treating insomnia with CBT-I

  A pilot test to see if a 6-week CBT-I program added to usual diabetes care helps sleep and diabetes control for adults with type 2 diabetes and insomnia in an FQHC setting.

  Recruiting Tulane University · Zachary, Louisiana · NCT07062406

• Insomnia in people with chronic non-cancer pain

  This study will see how common insomnia is and how it relates to chronic non-cancer pain in adults receiving care at pain clinics.

  Recruiting Germans Trias i Pujol Hospital · Badalona, Catalonia and 14 other locations · NCT07057232

• Cognitive-behavioral therapy with and without sleep restriction for insomnia in children aged 7-11

  This project will test whether adding sleep restriction to CBT-I helps children aged 7-11 with chronic insomnia sleep better.

  Recruiting Tel Aviv University · Tel Aviv, Israel · NCT07048340

• Rimazolen dosing during digestive endoscopy in people with insomnia

  This will see if people with insomnia need higher rimazolen doses than people with normal sleep during digestive endoscopy.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07028190

• Etomidate dose needed for adults with insomnia during digestive endoscopy.

  This will see if adults with insomnia need higher doses of etomidate than adults with normal sleep when having digestive endoscopy under intravenous anesthesia.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07028177

• Online Sleep Course for Public Safety Personnel

  This online cognitive behavioural therapy sleep course tests whether it helps public safety personnel (e.g., firefighters, paramedics, police, correctional workers) who have insomnia.

  Recruiting University of Regina · Regina, Saskatchewan · NCT07021183

• Eszopiclone for lowering blood pressure in adults with insomnia and high blood pressure

  This study tests whether eszopiclone can improve sleep and lower 24-hour ambulatory blood pressure in adults aged 30–75 who have insomnia and treated hypertension.

  Recruiting Phase 4 University of Sao Paulo · São Paulo, São Paulo · NCT07018557

• ASV Therapy for Insomnia: Can Adaptive Servo Ventilation Help Sleep Loss?

  This study tests whether adaptive servo ventilation can lessen insomnia symptoms in adults with moderate to severe chronic insomnia.

  Recruiting ResMed · Detroit, Michigan · NCT07011966

• Lemborexant for insomnia in adults with opioid use disorder on buprenorphine

  This trial will see if taking lemborexant each night for 8 weeks improves sleep, mood, and impulsive behavior in adults with moderate opioid use disorder who are stable on buprenorphine.

  Recruiting Phase 2 Virginia Commonwealth University · Richmond, Virginia · NCT06981195

• Bedtime mindfulness meditation for chronic trouble falling asleep

  This pilot will test whether a 4-week bedtime mindfulness app helps adults with chronic trouble falling asleep compared with an unguided meditation app or sleep hygiene education.

  Recruiting Phase 1/2 Brigham and Women's Hospital · Boston, Massachusetts · NCT06972303

• Combining Cognitive-behavioral Therapy with Transcranial Alternating Current for Treating Insomnia

  This study is testing if combining cognitive-behavioral therapy with a brain stimulation technique can help people with stubborn insomnia get better sleep.

  Recruiting Xuanwu Hospital, Beijing · Beijing · NCT06969040

• Evaluating a mobile app for chronic insomnia treatment in Italy

  This study tests whether a mobile app can help adults with chronic insomnia improve their sleep when used alongside their usual treatment.

  Recruiting Universita di Verona · Verona, Verona · NCT06926348

• Ciprofol dose needs for people with insomnia having digestive endoscopy.

  This project will test whether people with insomnia need higher doses of ciprofol during digestive endoscopy than people with normal sleep.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT06897007

• Exploring how insomnia affects health and fitness

  This study looks at how insomnia affects health and fitness in different groups of people to see what impact it has on things like body composition and exercise ability.

  Recruiting Universidad Autonoma de Baja California · Ensenada, Estado de Baja California · NCT06869486

• Cognitive Behavioral Therapy for Insomnia in Active-Duty Sailors with TBI

  This study is testing whether Cognitive Behavioral Therapy for Insomnia can help active-duty sailors with a history of traumatic brain injury sleep better, comparing traditional in-person sessions to a digital version.

  Recruiting Noctem, LLC · San Diego, California · NCT06867666

• Combining auricular pressure beans, electroacupuncture, and estazolam for treating cancer-related insomnia

  This study is testing whether a new treatment combining auricular pressure beans, electroacupuncture, and estazolam can help cancer patients with insomnia sleep better and feel less anxious or depressed.

  Recruiting Phase 3 Qinghai Red Cross Hospital · Xining, Qinghai · NCT06859190

• Digital sleep program for college students with insomnia

  This study tests whether a digital sleep program can help college students with insomnia sleep better and feel less anxious or depressed.

  Recruiting Taipei Medical University · Taipei · NCT06853106

• Using a dual orexin receptor antagonist to improve sleep and reduce neurodegeneration in adults with insomnia

  This study is testing if a new sleep medication can help adults with insomnia sleep better and possibly protect their brain from damage.

  Recruiting Phase 2 Woolcock Institute of Medical Research · Macquarie Park, New South Wales · NCT06823752

• Inhaled versus oral melatonin for adults with insomnia

  This trial will test whether a low-dose inhaled melatonin taken each night helps adults aged 55 and older with insomnia sleep differently than a standard oral melatonin tablet.

  Recruiting Early Phase 1 Woolcock Institute of Medical Research · Macquarie Park, New South Wales · NCT06802913

• Orexin-blocking treatment to help fear extinction in PTSD and insomnia

  This study tests whether suvorexant, a sleep medication that blocks orexin receptors, helps people with PTSD and insomnia by improving fear extinction learning.

  Recruiting Phase 4 VA Office of Research and Development · San Francisco, California and 1 other locations · NCT06788522

• Impact of massage chairs on sleep quality in people with insomnia

  This study is testing if using advanced massage chairs every night can help people with insomnia sleep better and feel happier over three months.

  Recruiting University of Thessaly · Trikala, Thessaly · NCT06788288

• Using low doses of esketamine to improve sleep quality after breast cancer surgery

  This study is testing whether low doses of esketamine can help improve sleep quality for people recovering from breast cancer surgery.

  Recruiting Nanjing First Hospital, Nanjing Medical University · Nanjing, Jiangsu · NCT06773143

• Comparing two therapies for insomnia treatment

  This study is testing whether a new sleep therapy called Bedtime Restriction Therapy works just as well as the more common Cognitive Behavioral Therapy for Insomnia to help adults with insomnia sleep better.

  Recruiting at 2 sites University of Geneva, Switzerland · Bern, Canton of Bern and 1 other locations · NCT06767137

• Online support for men adjusting to prostate cancer

  This study is testing if an online therapy program can help men dealing with emotional challenges after being diagnosed with prostate cancer.

  Recruiting Linkoeping University · Linköping · NCT06766526

• An online program to help adults with sleep difficulties

  This study tests an online program designed to help adults with sleep problems like insomnia and anxiety to see if it can improve their sleep and overall well-being.

  Recruiting University of Regina · Regina, Saskatchewan · NCT06745349

• Testing a sleep intervention for expectant and new mothers

  This study is testing a new sleep program for expectant and new mothers to see if it can help them get better sleep during and after pregnancy.

  Recruiting Rhode Island Hospital · Providence, Rhode Island · NCT06737055

• Rest-Up: brief programs to reduce heavy drinking and cannabis use and improve sleep in young adults

  This program will test short, integrated behavioral sessions to reduce heavy drinking and cannabis use and improve sleep in 18–29-year-olds with sleep problems who live in Washington State.

  Recruiting University of Washington · Seattle, Washington · NCT06736444

• Investigating sleep and cognition in older adults with insomnia

  This study tests how a new light therapy can improve sleep and thinking skills in older adults with insomnia, who are at risk for memory problems.

  Recruiting Northwestern University · Chicago, Illinois · NCT06694441

• Improving sleep in older adults with mild cognitive impairment using brain stimulation and CBT-I

  This trial will try combining gentle transcranial magnetic stimulation (TMS) with cognitive behavioral therapy for insomnia (CBT-I) to improve sleep in people aged 60 and older who have mild cognitive impairment or subjective cognitive decline.

  Recruiting Beth Israel Deaconess Medical Center · Boston, Massachusetts · NCT06687161

• Suvorexant for insomnia in people with alcohol use disorder and PTSD

  This study will test whether suvorexant can reduce insomnia in adults 21–65 who have moderate-to-severe alcohol use disorder and PTSD symptoms.

  Recruiting Phase 2 Pharmacotherapies for Alcohol and Substance Use Disorders Alliance · Los Angeles, California and 1 other locations · NCT06679062

• Program to support healthcare managers in promoting employee recovery

  This study tests a program that helps healthcare managers learn how to better support their employees' recovery from burnout and improve their sleep.

  Recruiting at 2 sites Karolinska Institutet · Gothenburg and 1 other locations · NCT06678347

• Individualized brain stimulation for treating insomnia

  This study is testing whether personalized brain stimulation can help people with insomnia sleep better.

  Recruiting Shanghai Mental Health Center · Shanghai, Shanghai Municipality · NCT06671457

• Timing rTMS sessions to improve sleep in people with insomnia

  This pilot will try giving low-frequency rTMS in the morning versus the evening to see if timing changes sleep for adults with insomnia.

  Recruiting Stanford University · Palo Alto, California · NCT06656533

• Suvorexant to treat insomnia in people with opioid use disorder.

  This trial tests whether suvorexant helps people with opioid use disorder fall asleep faster and stay asleep longer compared with placebo.

  Recruiting at 13 sites Phase 3 Merck Sharp & Dohme LLC · Garden Grove, California and 12 other locations · NCT06655883

• Acupuncture for Adolescents with Psychological Distress and Insomnia

  This trial tests whether Dense Cranial Electroacupuncture Stimulation plus Body Acupuncture helps teens with anxiety and sleep problems more than Minimal Acupuncture Stimulation.

  Recruiting The University of Hong Kong · Hong Kong, Hong Kong · NCT06638450

• Using Transcranial Magnetic Stimulation to Improve Sleep Quality

  This study is testing if a new treatment using magnetic stimulation can help people with insomnia sleep better.

  Recruiting University of Arizona · Tucson, Arizona · NCT06631209

• Investigating how sleep affects smoking cessation

  This study is testing whether improving sleep can help adults trying to quit smoking stay smoke-free longer by comparing two different support methods.

  Recruiting at 2 sites Phase 2 Yale University · New Haven, Connecticut and 1 other locations · NCT06609369

• Combining exercise coaching with insomnia treatment to reduce knee pain in older adults

  This study tests if adding sleep treatment to exercise coaching can help older adults with knee pain feel better than just exercise coaching alone.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT06580561

• Improving sleep and cognitive function in breast cancer survivors using an app

  This study is testing whether an app that helps with sleep can improve thinking skills in breast cancer survivors who have trouble sleeping.

  Recruiting Aarhus University Hospital · Aarhus N · NCT06553235

• Behavioral treatment for insomnia in military personnel with mild traumatic brain injury

  This study is testing two different types of therapy for insomnia to see which one helps active duty military personnel with mild traumatic brain injury sleep better.

  Recruiting The University of Texas Health Science Center at San Antonio · Fort Cavazos, Texas · NCT06551987

• Adapted Cognitive Behavioral Therapy for Insomnia in Teens

  This study is testing a new version of therapy for insomnia designed for teens to see if it helps them sleep better compared to those who aren't getting the treatment right away.

  Recruiting Indiana University · Indianapolis, Indiana · NCT06541886

• Progressive muscle relaxation exercises for pregnant women with pain and insomnia

  This study is testing if progressive muscle relaxation exercises can help pregnant women with pain and trouble sleeping feel better during their second and third trimesters.

  Recruiting Riphah International University · Mirpur, Azad Jammu & Kashmir · NCT06536764

• End sleepless nights during perimenopause.

  This trial will test whether hormone replacement therapy or weekly cognitive behavioral therapy for insomnia helps perimenopausal women with insomnia sleep better than weekly sleep-hygiene advice.

  Recruiting Phase 4 Insel Gruppe AG, University Hospital Bern · Bern · NCT06497894

• Improving sleep and reducing sedentary behavior in people with Type 2 diabetes

  This study is testing whether a program that includes therapy for sleep issues and support for being more active can help people with Type 2 diabetes sleep better and move more.

  Recruiting University of Leicester · Leicester, Leicestershire · NCT06471634

• Helping patients reduce reliance on sleep medications in primary care

  This study is testing a new way to help people with insomnia safely cut back on sleep medications by using a combination of online therapy and a plan to reduce their medication, compared to regular care.

  Recruiting Phase 4 National Jewish Health · Denver, Colorado · NCT06435520

• Comparing telehealth and web-based cognitive behavioral therapy for insomnia in people with multiple sclerosis

  This study is testing whether online therapy for insomnia delivered through video calls works better than web-based therapy or standard treatment to help people with multiple sclerosis sleep better and feel less tired.

  Recruiting Phase 2 University of Kansas Medical Center · Kansas City, Kansas · NCT06434571

• Mindfulness-based sleep program for pregnant women to prevent depression

  This study is testing a mindfulness-based sleep program to see if it can help pregnant women with insomnia reduce their risk of depression.

  Recruiting Phase 2 Henry Ford Health System · Novi, Michigan · NCT06430333

• Online prenatal CBT‑I program to improve sleep and reduce postpartum stress and depression risk

  This project will try an online cognitive behavioral sleep program for pregnant women with insomnia to see if better sleep lowers postpartum stress and depression.

  Recruiting at 2 sites University of Rome G. Marconi · Bologna, Bologna and 1 other locations · NCT06379074

• Comparing anesthetic dosage in insomnia patients during digestive endoscopy

  This study looks at whether people with insomnia need different amounts of anesthesia during digestive endoscopy compared to those who sleep normally.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT06376760

• Intelligent model for diagnosing and treating insomnia

  This study is trying to create better ways to diagnose and treat insomnia by following 16,000 people over two years to see how the condition affects their lives and what helps improve it.

  Recruiting at 3 sites Xuanwu Hospital, Beijing · Beijing and 4 other locations · NCT06375447

• Digital sleep optimization for older surgical patients

  This study is testing if a digital sleep program can help older patients sleep better and think clearer after major joint surgery compared to regular sleep education.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT06375265

• Investigating how sleep therapy affects emotional regulation

  This study is testing if sleep therapy can help improve emotional control and reduce feelings of depression in people struggling with insomnia.

  Recruiting Stanford University · Palo Alto, California · NCT06373718

• Digital therapy to improve sleep and mood in adolescents

  This study is testing a new online therapy for sleep problems to see if it can also help teenagers aged 12-18 who are dealing with both insomnia and depression feel better.

  Recruiting Chinese University of Hong Kong · Shatin, New Territories · NCT06358898

• Improving sleep to prevent depression and anxiety in at-risk adolescents

  This study is testing if a short therapy for sleep problems can help prevent depression and anxiety in teens aged 12 to 18 who are at risk because of their family history.

  Recruiting University of Calgary · Calgary, Alberta · NCT06358495

• Improving sleep for better mental health and school performance in teenagers

  This study tests two school programs designed to help teenagers aged 13-19 improve their sleep to see if it can boost their mental health and school performance.

  Recruiting Kristianstad University · Kristianstad, Skåne County · NCT06306092

• Improving sleep to reduce alcohol use

  This study is testing if treating insomnia can help people who drink heavily cut back on their alcohol use.

  Recruiting University of Missouri-Columbia · Columbia, Missouri · NCT06286774

• Effects of Cognitive Behavioral Therapy and Trazodone on Sleep and Blood Pressure in Insomnia

  This study is testing whether Cognitive Behavioral Therapy and trazodone can improve sleep quality and blood pressure in people with insomnia who either sleep less or have normal sleep duration.

  Recruiting at 4 sites Early Phase 1 Milton S. Hershey Medical Center · Denver, Colorado and 3 other locations · NCT06281756

• Transanal irrigation for sleep issues after rectal cancer surgery

  This study tests if a treatment called transanal irrigation can help adults with sleep problems after surgery for rectal cancer feel better and improve their sleep.

  Recruiting Seoul National University Hospital · Seoul, Jongro-gu · NCT06222255

• Comparing CBT-I and CBT-I with ACT for Youth Insomnia and Anxiety

  This study is testing whether combining cognitive-behavioral therapy for insomnia with acceptance and commitment therapy can help young people aged 15-24 sleep better and feel less anxious compared to just using cognitive-behavioral therapy alone.

  Recruiting Chinese University of Hong Kong · Shatin, New Territories · NCT06156306

• Examining the effects of pregabalin on sleep and pain in neuropathic pain patients

  This study is testing how pregabalin affects sleep and pain in people with chronic neuropathic pain to see if it helps them feel better.

  Recruiting at 2 sites Helsinki University Central Hospital · Helsinki, HUS and 1 other locations · NCT06155916

• Improving sleep to reduce pain after joint surgery

  This study is testing if helping people with insomnia sleep better before knee or hip surgery can reduce their pain after the operation.

  Recruiting Uppsala University · Uppsala, Uppland · NCT06145516

• Improving sleep and reducing nighttime urination in older adults

  This study is testing a new combined treatment to see if it can help older adults sleep better and reduce nighttime trips to the bathroom.

  Recruiting at 2 sites Atlanta VA Medical Center · Los Angeles, California and 1 other locations · NCT06110091

• A stepped care model to improve access to cognitive behavioral therapy for insomnia

  This study is testing a new way to make cognitive behavioral therapy for insomnia more accessible to people in Hong Kong to see if it helps them sleep better.

  Recruiting Chinese University of Hong Kong · Shatin, New Territories · NCT06109363

• Using Lemborexant to treat insomnia in patients with dementia

  This study is testing if a new sleep medication called lemborexant can help people with early-onset dementia sleep better without causing the usual side effects of other sleep aids.

  Recruiting Phase 4 Nova Scotia Health Authority · Halifax, Nova Scotia · NCT06093126

• Testing melatonin and low-dose quetiapine for insomnia in patients with psychiatric disorders

  This study is testing whether melatonin and a low dose of quetiapine can help people with psychiatric disorders sleep better compared to a placebo.

  Recruiting Phase 2/3 University of Copenhagen · Copenhagen NV · NCT06062953

• Online cognitive behavioral therapy for sleep and mental health in older adults with insomnia

  This study is testing an online therapy program to see if it can help older adults with insomnia improve their sleep and mental health.

  Recruiting at 2 sites Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal · Ottawa, Ontario and 1 other locations · NCT06032377

• mHealth intervention for improving sleep and cognition in low-income older adults

  This study is testing a mobile health program to see if it can help low-income older adults sleep better and think more clearly by encouraging physical activity and providing coaching.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT05935241

• Auricular acupuncture for treating depression during the Covid-19 pandemic

  This study is testing if auricular acupuncture can help university students with moderate depression feel better during the Covid-19 pandemic.

  Recruiting Universidade do Sul de Santa Catarina · Palhoça, Santa Catarina · NCT05855421

• Improving sleep in adults with cannabis use issues

  This study is testing whether a special online therapy for sleep problems can help adults who use cannabis for sleep feel better and sleep more soundly compared to regular sleep education.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT05814822

• Treating insomnia to improve weight loss in breast cancer survivors

  This study is testing whether a sleep therapy can help overweight or obese breast cancer survivors lose weight more effectively.

  Recruiting at 4 sites Johns Hopkins University · Washington D.C., District of Columbia and 3 other locations · NCT05780814

• Transcranial Direct Current Stimulation for Long COVID with Headaches and Chronic Pain

  This study tests whether applying mild brain stimulation (tDCS) can help people with long COVID who have headaches, migraines, and ongoing pain.

  Recruiting at 2 sites Fundación Universidad Católica de Valencia San Vicente Mártir · Paiporta, Valencia and 1 other locations · NCT05780450

• Evaluating behavioral treatments for insomnia in disadvantaged adults

  This study is testing whether a shorter online treatment for insomnia works just as well as a more traditional therapy for people with low income who have trouble sleeping.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT05759065

• Examining two behavioral methods to improve sleep in infants

  This study is testing two different ways to help infants with insomnia sleep better, comparing a method that involves checking on them at bedtime to a standard method that also helps with waking up at night.

  Recruiting Ben-Gurion University of the Negev · Beersheba · NCT05726890

• Light therapy to help adults with insomnia fall asleep faster

  This trial will test whether daily light delivered through special glasses helps adults aged 30–60 with insomnia fall asleep faster.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT05715411

• Improving sleep for individuals with traumatic brain injury

  This study tests a new online therapy program to help people with moderate to severe traumatic brain injury improve their sleep quality compared to standard treatment.

  Recruiting VA Eastern Colorado Health Care System · Aurora, Colorado · NCT05683145

• Training therapists to provide evidence-based therapies for cancer patients

  This study is testing whether training therapists to provide personalized therapy can help cancer patients manage their stress and improve their overall well-being during treatment.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT05674357

• Comparing two therapies for insomnia in veterans with traumatic brain injury

  This study is testing whether online therapy for insomnia or mindfulness techniques can help veterans with brain injuries sleep better and feel less depressed.

  Recruiting at 5 sites Johns Hopkins University · Eglin Air Force Base, Florida and 4 other locations · NCT05663034

• Internet-based therapy for insomnia and cognitive health

  This study is testing whether an online therapy for insomnia can help improve sleep and thinking skills in people with mild cognitive impairment.

  Recruiting Phase 2 University of Virginia · Charlottesville, Virginia · NCT05565833

• Treating insomnia to improve heart and metabolic health in older adults with PTSD

  This study is testing if treating insomnia with therapy can help older adults with PTSD improve their heart health and overall well-being.

  Recruiting University of California, Los Angeles · North Hills, California · NCT05516277

• Forehead temperature therapy for insomnia in adults with Tourette's disorder

  This study tests if a forehead temperature therapy can help adults with Tourette's disorder sleep better and feel less anxious and depressed.

  Recruiting University of California, Los Angeles · Los Angeles, California · NCT05499741

• Preventing insomnia in at-risk youth

  This study is testing a program to help young people aged 15-24 who are at risk of insomnia to see if it can prevent them from developing sleep problems in the future.

  Recruiting Chinese University of Hong Kong · Shatin, NT · NCT05451524

• Pimavanserin for treating insomnia in veterans with PTSD

  This study is testing if a medication called pimavanserin can help veterans with PTSD sleep better by comparing it to a placebo over eight weeks.

  Recruiting Phase 2 VA Office of Research and Development · Houston, Texas · NCT05441280

• Nurse-guided treatment for insomnia in patients recovering from brain injuries

  This study is testing whether a nurse-guided treatment for insomnia can help people recovering from brain injuries sleep better and improve their mood and thinking.

  Recruiting at 2 sites Taipei Medical University · Taipei and 1 other locations · NCT05402761

• Investigating how sleep loss affects emotion regulation

  This study is testing how losing sleep for three nights affects people's ability to handle their emotions compared to those with insomnia and healthy individuals.

  Recruiting Beth Israel Deaconess Medical Center · Boston, Massachusetts · NCT05393830

• Program to improve sleep and reduce suicidal behavior in adolescents

  This study is testing a new program to help teenagers who have trouble sleeping and are feeling suicidal, to see if it can improve their sleep and reduce their suicidal thoughts.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT05390918

• Registry of patients with sleep disorders

  This study is collecting information from people with sleep disorders to see how these conditions affect their lives and to track their progress over time.

  Recruiting Johannes Gutenberg University Mainz · Mainz, Rhineland-Palatinate · NCT05321355

• Comparing two treatments for insomnia in veterans with PTSD

  This study is trying out a new treatment for insomnia that combines different therapy techniques to see if it helps veterans with PTSD sleep better and feel less anxious compared to standard therapy.

  Recruiting VA Office of Research and Development · Sepulveda, California and 1 other locations · NCT05194930

• A smartphone app to improve mental health and sleep

  This study is testing a free smartphone app that helps people in France manage stress and improve their sleep through personalized support and digital therapy.

  Recruiting University of Bordeaux · Bordeaux · NCT05074901

• Digital platform for treating insomnia with cognitive-behavioral therapy

  This study is testing a digital program that uses therapy to help people aged 20 to 60 with mild insomnia sleep better compared to traditional treatments.

  Recruiting SleepUp Tecnologia em Saúde Ltda · São Caetano do Sul, São Paulo · NCT04949360

• Using wearable technology to improve sleep staging

  This study is testing whether using wearable devices and smartphones can help improve how we track and understand sleep patterns in healthy young adults compared to traditional sleep studies.

  Recruiting at 2 sites SleepUp Tecnologia em Saúde Ltda · São Caetano do Sul, São Paulo and 1 other locations · NCT04943562

• Evaluating the impact of self-help CBT in primary care behavioral health

  This study is testing if adding guided self-help therapy to regular mental health care can help patients feel better and improve their daily lives.

  Recruiting at 2 sites Linnaeus University · Varberg, Halland County and 3 other locations · NCT04900064

• Web-based intervention for insomnia in rural dementia caregivers

  This study is testing a new online program to help rural caregivers of people with dementia improve their sleep and overall well-being.

  Recruiting University of South Florida · Tampa, Florida · NCT04896775

• Understanding how drugs work in children

  This study is trying to find the best and safest doses of certain medications for children and young adults under 21 who are being treated for conditions like COVID-19 and pulmonary arterial hypertension.

  Recruiting at 5 sites Duke University · Phoenix, Arizona and 51 other locations · NCT04278404

• Investigating brain response variability to predict success in online therapy for mental health

  This study is testing if changes in brain activity can help predict how well online therapy works for people with depression, anxiety, and insomnia.

  Recruiting Karolinska Institutet · Huddinge, Stockholm County · NCT04191811

NIH-funded research (newest 40 of 101)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Cognitive behavioral therapy and trazodone for insomnia phenotypes with high blood pressure

  A clinical study tests how CBT-I and the sleep drug trazodone work for adults with insomnia and high blood pressure, focusing on a specific sleep duration pattern.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11635771

• DESCANSO: A friendly CBT plan to ease depression, sleep problems, and fatigue in Latino cancer patients

  A Spanish-speaking CBT program called DESCANSO is being tested to help Latino cancer patients feel less tired, sleep better, and happier.

  NIH research Ponce School of Medicine · Ponce, United States · NIH-11601026

• Pimavanserin for Sleep Problems in Veterans with PTSD

  This grant supports Dr. Melissa Jones to study a new medicine, pimavanserin, to help veterans with PTSD sleep better.

  NIH research Michael E Debakey VA Medical Center · Houston, United States · NIH-11591888

• Improving WTC responder mental health with personalized sleep treatment for COMISA

  Aimed at helping World Trade Center responders who have both insomnia and sleep apnea feel better by using a tailored combination of sleep therapies.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11578881

• A new sleep-help approach for Veterans with PTSD

  A new ACT-based insomnia treatment tailored for Veterans with PTSD aims to improve sleep and quality of life.

  NIH research Miami VA Health Care System · Miami, United States · NIH-11547958

• Cognitive Behavioral Therapy for Insomnia to Help Veterans with Psychosis

  A veteran-focused CBT-I program tailored for those with psychosis aims to improve sleep and daily functioning.

  NIH research Baltimore VA Medical Center · Baltimore, United States · NIH-11511695

• Insomnia, Depression, and Sleep Medications in Mild Cognitive Impairment Leading to Dementia

  This project looks at how sleep problems and depression, along with the medicines used to treat them, may affect the progression from mild cognitive issues to dementia in older adults.

  NIH research Saint Louis University · Saint Louis, United States · NIH-11438046

• Healthy sleep and pain relief for people living with HIV

  A patient-centered plan tests a non-drug sleep program to reduce insomnia and pain in people with HIV who also have ongoing pain.

  NIH research Washington University · Saint Louis, United States · NIH-11421404

• Insomnia subtypes and sleep meds: CBT-I and trazodone for adults with high blood pressure

  We’re testing whether a sleep therapy (CBT-I) and the antidepressant trazodone help adults with insomnia and high blood pressure, especially those with the short-sleep-insomnia subtype.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11418414

• Cognitive-Behavioral Therapy and Trazodone for Sleep and Blood Pressure in Insomnia Subtypes

  This program tests how CBT-I and trazodone help sleep and blood pressure in adults with insomnia, focusing on those with short sleep duration versus normal sleep duration.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11416636

• Sleep therapy versus trazodone for short-sleep insomnia and high blood pressure

  This project compares a talk-based sleep program (CBT-I) and the medication trazodone to help adults with insomnia who also have elevated blood pressure, especially those who sleep less at night.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11416298

• Somni: a digital program to treat insomnia and insufficient sleep in adults

  A new digital sleep program called Somni tests whether a combined coaching, education, sleep products, and wearable monitoring helps adults with insomnia and short sleep duration.

  NIH research Pure Somni Corporation · Madison, United States · NIH-11405325

• Hybrid approach to treating insomnia in socioeconomically disadvantaged adults in primary care

  A study tests whether a shorter, easier-to-deliver insomnia treatment works as well as standard therapy for low-income adults seen in primary care.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11402725

• Online sleep therapy to prevent depression during and after pregnancy

  This project will see whether an online cognitive behavioral therapy for insomnia can help prevent depression during pregnancy and in the first year after childbirth for pregnant people with insomnia.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11402619

• Parent-Mediated Telehealth Sleep Therapy for Autistic Children

  A large, multisite telehealth program helps families of autistic children improve nighttime sleep and reduce caregiver stress using parent-led behavioral strategies.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11400968

• Bright light therapy added to sleep training to reduce pain after knee surgery in older adults

  This project tests whether adding morning bright light therapy to cognitive-behavioral therapy for insomnia can lower chronic pain and reduce opioid use after knee replacement in older adults.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11387674

• Move and Snooze: add sleep help to an exercise plan to ease knee pain in older adults

  A program combines a personalized exercise plan with a digital sleep-improvement course to reduce knee pain for adults aged 65 and up who have osteoarthritis.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11384493

• Understanding insomnia during alcohol withdrawal through brain cell activity

  Researchers study how brain sleep and wake signals change during alcohol withdrawal in a mouse model to understand why insomnia occurs and how it might be treated.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11380979

• How sleep and the brain's orexin system affect recovery while on buprenorphine

  This project tests whether targeting the brain's orexin system can improve sleep and lower relapse risk for people taking buprenorphine for opioid use disorder.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11371168

• Using CBT for insomnia to help women veterans engage in PTSD care

  This project will try giving Cognitive Behavioral Therapy for Insomnia (CBT‑I) to women veterans with PTSD to help them get into and stick with PTSD treatment.

  NIH research VA Greater Los Angeles Healthcare System · Los Angeles, United States · NIH-11365625

• Improving Sleep to Help Weight Loss in Breast Cancer Survivors

  A study tests whether improving sleep with a proven therapy helps breast cancer survivors lose more weight when they start a weight loss program.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11365036

• Understanding how the brain’s orexin system links sleep, mood, and opioid use disorder

  Scientists will study how the orexin system in the brain relates to insomnia and relapse risk in adults with opioid use disorder who are on buprenorphine treatment.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11362669

• Targeting insomnia to help adults who use cannabis

  We’re testing a sleep-focused treatment to help adults with heavy cannabis use reduce sleep problems and cannabis use.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11359689

• CBT for Insomnia to Help Adults Who Smoke Quit and Sleep Better

  A sleep-focused therapy is tested to help adults who smoke sleep better, feel less negative, and improve their ability to quit smoking.

  NIH research Yale University · New Haven, United States · NIH-11353933

• Understanding how sleep problems in older couples relate to thinking skills and Alzheimer's risk

  This project looks at how insomnia in older couples may influence memory and thinking over time, with the goal of better understanding Alzheimer’s disease progression.

  NIH research University of Missouri-Columbia · Columbia, United States · NIH-11333382

• An adaptive plan to help pain after CBT for insomnia in people with chronic back pain

  A patient-facing program will test a supplemental, hopeful approach added to standard CBT for insomnia to see if it can reduce pain for people who have chronic low back pain and insomnia.

  NIH research University of Virginia · Charlottesville, United States · NIH-11332862

• Sleep therapy tailored for adults in opioid treatment

  A tailored cognitive-behavioral sleep program aims to help adults with opioid use disorder and insomnia sleep better and stay in medication treatment.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11325031

• Can CBT-I change a brain receptor linked to depression?

  This project looks at whether a sleep therapy called CBT-I changes a brain glutamate receptor (mGluR5) and helps adults with depression and insomnia.

  NIH research State University New York Stony Brook · Stony Brook, United States · NIH-11324636

• Redefining Insomnia by marrying how people feel with what’s happening in the body

  A doctor-scientist team at the University of Pennsylvania is exploring a new way to understand insomnia by combining patients’ sleep experiences with biological clues to guide more personalized care.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11321094

• Brief insomnia treatment for Veterans with PTSD

  A home-friendly, short program using video and phone calls to help Veterans who have insomnia and PTSD sleep better and feel more able to function in daily life.

  NIH research Veterans Affairs Med Ctr San Francisco · San Francisco, United States · NIH-11310801

• Suvorexant to improve sleep in people receiving treatment for opioid use disorder

  People on medications for opioid use disorder who have insomnia will be given suvorexant or a placebo to see if it helps their sleep, cravings, and withdrawal symptoms.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11309185

• Mi Sleep Coach: A digital helper to improve sleep for adults with cancer

  A smartphone app helps adults with cancer-related insomnia sleep better using a survivor-centered digital coaching approach.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11295812

• Improving sleep to lower diabetes risk

  This program gives adults with prediabetes and insomnia a six-session online cognitive behavioral therapy for insomnia to see if improving sleep lowers blood sugar.

  NIH research Kaiser Foundation Research Institute · Oakland, UNITED STATES · NIH-11289310

• Using kava to help adults quit smoking by easing stress and improving sleep

  This project looks at whether a kava supplement can help adult smokers quit by reducing withdrawal-related stress and sleep problems.

  NIH research University of Florida · Gainesville, United States · NIH-11283931

• Acceptance-based sleep program for Veterans with PTSD

  This program combines behavioral sleep techniques with Acceptance and Commitment Therapy to help Veterans with PTSD who have chronic insomnia.

  NIH research VA Greater Los Angeles Healthcare System · Los Angeles, United States · NIH-11269164

• Path to Better Sleep: online insomnia program with virtual coaching for Veterans

  This program offers Veterans with insomnia an online CBTi course called Path to Better Sleep plus virtual coaching to help them complete the program and sleep better.

  NIH research VA Connecticut Healthcare System · West Haven, United States · NIH-11231661

• Targeting Insomnia to Prevent Depression in Menopause

  A large study will test whether treating sleep problems with a digital cognitive-behavioral therapy program can help prevent depression in women going through menopause.

  NIH research Sri International · Menlo Park, United States · NIH-11219445

• Comparing a sleep medication and therapy for Veterans with PTSD and insomnia

  This study is looking at whether a sleep medication called eszopiclone or short therapy sessions can help Veterans with PTSD sleep better and stick to using their CPAP machines, so they can feel more rested and improve their overall well-being.

  NIH research VA Western New York Healthcare System · Buffalo, United States · NIH-11212732

• Maternal insomnia and child social-emotional outcomes: following families over time

  A study tests whether treating a mother’s sleep problems during pregnancy and after birth improves her child’s social and emotional development by age 2–4 years.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11208690

• Improving sleep for veterans with psychosis using therapy

  This study is testing a special sleep therapy called Cognitive Behavioral Therapy for Insomnia (CBT-I) to help veterans with psychosis get better sleep and feel more functional in their daily lives.

  NIH research Baltimore VA Medical Center · Baltimore, United States · NIH-11196057

Related topics

Quick answers

How many Insomnia clinical trials are recruiting right now?

147, as of November 12, 2026. 3 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 25 countries. The most sites are in United States (60 trials), China (15 trials), Hong Kong (11 trials), Canada (9 trials), Sweden (7 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 12, Phase 4: 7, Early Phase 1: 3, Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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