Etomidate dose needed for adults with insomnia during digestive endoscopy.
Official title: Changes in Etomidate Dosage in Patients With Insomnia Undergoing Intravenous Anesthesia: a Prospective Cohort Study
Run by Beijing Tiantan Hospital · NCT07028177 · Data updated 2026-11-12
This will see if adults with insomnia need higher doses of etomidate than adults with normal sleep when having digestive endoscopy under intravenous anesthesia.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 64 Years |
| Sex | All |
| Enrollment | 840 (estimated) |
| Sponsor | Beijing Tiantan Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Status | Recruiting |
| Started | June 12, 2025 |
| Main results expected | March 31, 2027 |
| Study ends | March 31, 2027 |
| Registry record updated | July 22, 2026 |
| Trial ID | NCT07028177 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults 18–64 with ASA I–II and BMI 15–30 who are scheduled for digestive endoscopy under intravenous anesthesia and who meet DSM-5 criteria for insomnia with an SCI score of 16 or less.
✕Probably not a fit
Patients with neurological disease, daily alcohol use, contraindications to intravenous anesthetics, drug allergies, those outside the 18–64 age range, ASA class >II, BMI outside 15–30, or not undergoing endoscopy are unlikely to benefit from this observational comparison.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study compares the amount of etomidate used to induce and maintain sedation during digestive endoscopy between adults with insomnia and adults with normal sleep patterns. Eligible participants are aged 18–64 with ASA physical status I–II and BMI 15–30 who are scheduled for digestive endoscopy under intravenous anesthesia, with insomnia defined by DSM-5 criteria and an SCI score of 16 or less. Investigators will record etomidate dose requirements and routine clinical outcomes without assigning experimental interventions. The work is led by Beijing Tiantan Hospital with collaboration from several regional hospitals.
Why it matters
Potential benefit: If successful, the findings could help anesthesiologists tailor etomidate dosing for patients with insomnia to improve safety and comfort.
How similar studies have gone: Direct comparisons of etomidate dosing in insomnia versus normal sleepers are limited, so this approach is relatively novel with limited prior evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with insomnia: 1. Age of 18 - 64 years; 2. American Society of Anesthesiologists (ASA) physical status of I - II; 3. Body mass index (BMI) of 15 - 30; 4. Patients undergoing elective thoracoscopy, laparoscopy, hysteroscopy, open abdominal surgery, open thoracic surgery, open spinal surgery, craniotomy surgery, and digestive endoscopy under general anesthesia; 5. Positive screening results according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for insomnia disorder; 6. 8-item Sleep Condition Indicator (SCI; score 0-4; range 0-32, higher score means better sleep) scored 16 or less. * Patients with normal sleep: 1. Age of 18 - 64 years; 2. ASA physical status of I - II; 3. BMI of 15 - 30; 4. Patients undergoing elective thoracoscopy, laparoscopy, hysteroscopy, open abdominal surgery, open thoracic surgery, open spinal surgery, craniotomy surgery, and digestive endoscopy under general anesthesia; 5. No history or evidence of insomnia. Exclusion Criteria: 1. Associated with any neurological disease; 2. Daily alcohol consumption; 3. Any contraindication to intravenous anesthetic drug, such as hypotension or shock; 4. History of allergy to any drug used in the study; 5. Pregnancy or breastfeeding; 6. Patients with sleep apnea syndrome; 7. acute upper respiratory infection; 8. Patients with psychological diseases who report suicidal thoughts; 9. Patients who need to work or take care of children/elderly people frequently at night.
Where it's running
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Beijing Tiantan Hospital
Beijing, Beijing Municipality, China Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.