Rest-Up: brief programs to reduce heavy drinking and cannabis use and improve sleep in young adults
Official title: Efficacy of Brief Interventions to Reduce Comorbid Alcohol and Cannabis Misuse and Sleep Impairment in Young Adults (Rest-Up RCT)
Run by University of Washington · NCT06736444 · Data updated 2026-11-12
This program will test short, integrated behavioral sessions to reduce heavy drinking and cannabis use and improve sleep in 18–29-year-olds with sleep problems who live in Washington State.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 29 Years |
| Sex | All |
| Enrollment | 800 (estimated) |
| Sponsor | University of Washington Academic / other |
| Locations | 1 site (Seattle, Washington) |
| Status | Recruiting |
| Started | July 2, 2025 |
| Main results expected | April 1, 2029 |
| Study ends | April 1, 2029 |
| Registry record updated | April 14, 2026 |
| Trial ID | NCT06736444 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are 18–29-year-olds who live in Washington State, have at least moderate insomnia (ISI ≥10), report recent heavy episodic drinking as defined by the protocol, and have used cannabis four or more times in the past month.
✕Probably not a fit
People outside the age or residency requirements, those without sleep impairment or without recent heavy drinking or cannabis use, and individuals with more severe substance use disorders needing specialized care may not receive benefit from this brief intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized interventional study enrolls young adults with insomnia, recent heavy episodic drinking, and regular cannabis use to receive a brief integrated intervention or an attention-control condition. The active intervention combines Brief Behavioral Therapy for Insomnia (BBTI) with the Brief Alcohol Screening and Intervention for College Students (BASICS) to target sleep, alcohol, and cannabis use together. Outcomes include changes in alcohol and cannabis use and related consequences, plus sleep severity and daytime functioning, measured over follow-up. Recruitment is limited to residents of Washington State and sessions are delivered through the University of Washington research program.
Why it matters
Potential benefit: If successful, this brief combined approach could help young adults reduce heavy drinking and cannabis use and improve sleep using short, scalable sessions.
How similar studies have gone: Components of this approach have prior support—BBTI improves insomnia and BASICS reduces college drinking—but using them together to treat co-occurring alcohol, cannabis, and sleep problems is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants must: 1) be 18-29 years old; 2) reside in Washington State; 3) have valid email address; 4) score on the Insomnia Severity Index (ISI) of 10 or higher, indicating at least a moderate score (score of 2 or more) on one or more of the first three items of the ISI measuring difficulty falling asleep, staying asleep, or waking up too early; 5a) report at least two heavy drinking episodes (4+ drinks for women /gender diverse, 5+ for men in a 2-hour period) in the past month; or 5b) 1 heavy drinking occasion and at least 4 total drinking occasions in the past month; 6) have used cannabis 4+ times in the past month; and 7) did not participate in the R34 pilot feasibility trial on which the current RCT is based. Exclusion Criteria: * Participants that don't meet inclusion criteria and/or failure to consent to further participation.
Where it's running
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University of Washington
Seattle, Washington, United States Recruiting
Study contacts
- Principal investigator: Mary E Larimer, Ph.D. — University of Washington
- Study coordinator: Mary E Larimer, Ph.D.
- Email: larimer@uw.edu
- Phone: 206-543-3513
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.