Cognitive-Behavioral Therapy and Trazodone for Sleep and Blood Pressure in Insomnia Subtypes

Who could benefit from this research

What this research studies

Insomnia is common and tied to higher risks for heart, metabolism, and mental health issues. The study zeroes in on a insomnia with short sleep duration (ISS) phenotype and compares its treatment response to insomnia with normal sleep duration (INS) when adults also have elevated blood pressure. It starts with a four-site observational cohort, then moves to a placebo-controlled randomized trial to test CBT-I and trazodone in 600 adults. The goal is to see if ISS and INS respond differently to these treatments, with CBT-I as the standard first-line therapy and trazodone as an additional option for non-responders. The research will measure sleep outcomes, blood pressure, and hormonal stress markers to guide future personalized insomnia care.

Why it matters

Where this research is happening

• University of Pittsburgh at Pittsburgh
  Pittsburgh, United States Active

Researchers

• Principal investigator: Wisniewski, Stephen R — University of Pittsburgh at Pittsburgh
• Study coordinator: Wisniewski, Stephen R

Related research

Other NIH-funded projects on the same topics.

• Cognitive behavioral therapy and trazodone for insomnia phenotypes with high blood pressure

  A clinical study tests how CBT-I and the sleep drug trazodone work for adults with insomnia and high blood pressure, focusing on a specific sleep duration pattern.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11635771

• Insomnia subtypes and sleep meds: CBT-I and trazodone for adults with high blood pressure

  We’re testing whether a sleep therapy (CBT-I) and the antidepressant trazodone help adults with insomnia and high blood pressure, especially those with the short-sleep-insomnia subtype.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11418414

• Sleep therapy versus trazodone for short-sleep insomnia and high blood pressure

  This project compares a talk-based sleep program (CBT-I) and the medication trazodone to help adults with insomnia who also have elevated blood pressure, especially those who sleep less at night.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11416298

• Behavioral therapy and trazodone for insomnia types that affect sleep time and blood pressure

  This research will compare cognitive behavioral therapy and the medication trazodone to help adults with insomnia and high blood pressure sleep more and lower their blood pressure.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11168708

• Cognitive behavioral therapy and trazodone for insomnia-related short sleep and high blood pressure

  This project compares talk-based sleep therapy and the medication trazodone to help adults with insomnia sleep longer and lower their blood pressure, especially if they sleep less than usual.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11166505

• Effects of therapy and medication on sleep and blood pressure in people with insomnia

  This study is looking at how two different treatments—Cognitive Behavioral Therapy for Insomnia (CBT-I) and the medication trazodone—can help improve sleep quality and lower blood pressure in adults who struggle with insomnia, especially those who don’t get enough sleep.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-10951138

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.