Remote ischemic conditioning for post-stroke insomnia
Official title: The Role and Mechanism of Adenosine A2A Receptor-Mediated Neuroinflammation in the Alleviation of Post-Stroke Sleep Disorders by Remote Ischemic Conditioning
Run by Sichuan Academy of Medical Sciences · NCT07874594 · Data updated 2026-11-12
A 136-person, randomized study will test whether a non-invasive arm-cuff procedure done twice daily for 90 days can improve sleep after a first ischemic stroke in adults 18–80.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 136 (estimated) |
| Sponsor | Sichuan Academy of Medical Sciences Academic / other |
| Locations | 1 site (Chengdu, Sichuan) |
| Status | Recruiting |
| Started | September 1, 2026 |
| Main results expected | December 31, 2028 |
| Study ends | December 31, 2029 |
| Registry record updated | October 15, 2026 |
| Trial ID | NCT07874594 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–80 who had a first ischemic stroke 3–6 months ago, are right-handed, have mRS ≤3, and report insomnia (PSQI >5).
✕Probably not a fit
Patients without insomnia, with other sleep disorders, or with conditions that exclude sleep-modifying meds or severe comorbidity may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a single-center, prospective, randomized, double‑blind, sham‑controlled trial. Participants with insomnia after a first ischemic stroke 3–6 months earlier are assigned to remote ischemic conditioning (RIC) or a sham control, delivered via arm cuffs at 200 mmHg vs 60 mmHg for 45 minutes per session, twice daily for 90 days. The study will look at sleep quality using the Pittsburgh Sleep Quality Index (PSQI) at 90 days as the primary outcome, with secondary measures relating to sleep and potential mechanisms involving adenosine A2A receptors and neuroinflammation. Eligible adults are right-handed, 18–80, with mRS ≤3 and PSQI >5; several sleep-related or medical exclusions apply. The trial is led by Sichuan Academy of Medical Sciences in Chengdu, with no listed collaborators.
Why it matters
Potential benefit: If successful, the approach could provide a non-pharmacologic option to improve sleep after stroke.
How similar studies have gone: Prior research in neuromodulation and non-invasive conditioning has shown signals of potential benefit in related conditions, but this exact approach for post-stroke insomnia is exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 to 80 years. * Right-handed. * First-ever stroke, with imaging-confirmed ischemic cerebral infarction. * Receiving routine treatment for ischemic stroke. * Time since stroke onset: 3 months ≤ onset time ≤ 6 months. * Modified Rankin Scale (mRS) score ≤3. * Presence of insomnia complaints, defined as Pittsburgh Sleep Quality Index (PSQI) score \>5. Exclusion Criteria: * Diagnosis of chronic insomnia within 3 months before stroke onset, or a history of other sleep disorders. * Presence of significant manifestations of sleep apnea. * Concomitant other neuropsychiatric disorders. * Concomitant severe somatic diseases, such as acute illness or infectious diseases. * Use of medications that affect sleep within 2 weeks before enrollment. * History of shift work or jet lag within 4 months before enrollment, or planned shift work or jet lag within 3 months after enrollment. * Pregnant or breastfeeding women. * History of alcohol abuse or psychoactive substance use within the past year. * Inability to complete CT, MRI, or other imaging examinations. * Body mass index (BMI) ≥35 kg/m². * Current participation in another clinical trial. * Dementia, aphasia, or other conditions that, in the investigator's opinion, make the participant unsuitable for enrollment.
Where it's running
-
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
Chengdu, Sichuan, China Recruiting
Study contacts
- Study coordinator: Xian Wang
- Email: cowangxian@163.com
- Phone: +86-132-6908-7917
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.