Treating insomnia to improve heart and metabolic health in older adults with PTSD

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot trial aims to explore the effects of treating insomnia in older adults with Posttraumatic Stress Disorder (PTSD) on their cardiometabolic health. Participants will undergo Cognitive Processing Therapy (CPT) for PTSD followed by Cognitive Behavioral Therapy for Insomnia (CBT-I) to address residual sleep difficulties. The study will evaluate the impact of these interventions on sleep quality, PTSD symptoms, cardiometabolic risk factors, and overall quality of life. Participants will be monitored through various assessments, including wearable devices for sleep patterns and continuous glucose monitoring.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Community-dwelling Veterans aged 50 years and older
* Received care from a Veterans Health Administration (VHA) facility in the prior year
* Diagnosis of PTSD
* Diagnosis of insomnia disorder
* Lives within a 50-mile radius of the research offices at the VA Sepulveda Ambulatory Care Center

Exclusion Criteria:

* Active substance use or in recovery with less than 90 days of sobriety
* Too ill to engage in the study procedures (e.g., unable to attend the in-person meetings)
* Unable to self-consent to participate
* Unstable housing (as this will impact the research team's ability to retrieve costly and difficult to replace monitoring equipment)
* Severe cardiovascular or respiratory disease (e.g., ventilatory failure, CHF)
* Unstable medical or psychiatric disorders (which are a contraindication for behavioral treatment of insomnia)
* Comorbid sleep disorders (i.e., central sleep apnea syndrome, diagnosed narcolepsy or circadian rhythm sleep-wake phase disorders) based on medical record review and baseline assessment data, or untreated, severe sleep disordered breathing (SDB) as assessed via WatchPAT or previous clinical evaluation (apnea-hypopnea index \[AHI\] ≥ 30; or AHI ≥ 15 plus Epworth Sleepiness Scale \[ESS\] score ≥ 10) that better explain sleep difficulties

Where it's running

• VA Greater Los Angeles Healthcare System
  North Hills, California, United States Recruiting

Study contacts

• Principal investigator: Monica Kelly, PhD — UCLA / VA Greater Los Angeles
• Study coordinator: Monica Kelly, PhD
• Email: monica.kelly2@va.gov
• Phone: 818-891-7711

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Lowering blood pressure by adding stair climbing to brisk walking

  We will test whether adding short daily stair climbing to a brisk-walking program lowers systolic blood pressure in adults 35 and older who have high blood pressure, are overweight, and are not regularly active.

  Recruiting Karolinska Institutet · Stockholm and 3 other locations · NCT06952348

• Exploring how insomnia affects health and fitness

  This study looks at how insomnia affects health and fitness in different groups of people to see what impact it has on things like body composition and exercise ability.

  Recruiting Universidad Autonoma de Baja California · Ensenada, Estado de Baja California · NCT06869486

• Examining drug interactions in older adults living with HIV

  This study looks at how different medications interact in older adults with HIV to see if we can improve their treatment plans.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna · NCT06717581

• Predicting depression in patients after heart surgery

  This study is trying to see if a new tool can help predict which patients might develop depression after heart surgery, so they can get help sooner.

  Recruiting University of Zurich · Zurich and 1 other locations · NCT06706323

• Collection of biospecimens for cardiovascular and metabolic research

  This study is collecting blood, urine, stool, and heart tissue samples from people with and without heart and metabolic diseases to help researchers learn more about these conditions and improve treatments.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06560424

• Comparing three short running HIIT schedules for cardiometabolic health in young adults with obesity

  This project will try three different short-term running HIIT schedules versus no training to see which best improves cardiometabolic markers in 18–25-year-olds with obesity.

  Recruiting Syracuse University · Syracuse, New York · NCT05838950

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.