Insomnia subtypes and sleep meds: CBT-I and trazodone for adults with high blood pressure

Who could benefit from this research

What this research studies

This project will enroll adults with insomnia and elevated blood pressure to see if CBT-I works differently for those who sleep short vs. normal duration. After a 4-site observational phase, participants who do not fully respond to CBT-I may be randomized to trazodone or placebo to see if the medication helps sleep and lowers blood pressure. The study builds on prior findings showing ISS may respond differently to CBT-I and trazodone, with potential effects on sleep time, blood pressure, and cortisol. If successful, the approach could personalize insomnia treatment for people at cardiovascular risk.

Why it matters

Where this research is happening

• Pennsylvania State Univ Hershey Med Ctr
  Hershey, United States Active

Researchers

• Principal investigator: Vgontzas, Alexandros N — Pennsylvania State Univ Hershey Med Ctr
• Study coordinator: Vgontzas, Alexandros N

Related research

Other NIH-funded projects on the same topics.

• Cognitive behavioral therapy and trazodone for insomnia phenotypes with high blood pressure

  A clinical study tests how CBT-I and the sleep drug trazodone work for adults with insomnia and high blood pressure, focusing on a specific sleep duration pattern.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11635771

• Cognitive-Behavioral Therapy and Trazodone for Sleep and Blood Pressure in Insomnia Subtypes

  This program tests how CBT-I and trazodone help sleep and blood pressure in adults with insomnia, focusing on those with short sleep duration versus normal sleep duration.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11416636

• Sleep therapy versus trazodone for short-sleep insomnia and high blood pressure

  This project compares a talk-based sleep program (CBT-I) and the medication trazodone to help adults with insomnia who also have elevated blood pressure, especially those who sleep less at night.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11416298

• Behavioral therapy and trazodone for insomnia types that affect sleep time and blood pressure

  This research will compare cognitive behavioral therapy and the medication trazodone to help adults with insomnia and high blood pressure sleep more and lower their blood pressure.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11168708

• Cognitive behavioral therapy and trazodone for insomnia-related short sleep and high blood pressure

  This project compares talk-based sleep therapy and the medication trazodone to help adults with insomnia sleep longer and lower their blood pressure, especially if they sleep less than usual.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11166505

• Effects of therapy and medication on sleep and blood pressure in people with insomnia

  This study is looking at how two different treatments—Cognitive Behavioral Therapy for Insomnia (CBT-I) and the medication trazodone—can help improve sleep quality and lower blood pressure in adults who struggle with insomnia, especially those who don’t get enough sleep.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-10951138

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.