Using low doses of esketamine to improve sleep quality after breast cancer surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of subanesthetic doses of esketamine on sleep quality in patients undergoing modified radical mastectomy for breast cancer. A total of 184 participants will be enrolled, and their sleep quality will be assessed using various scales before and after surgery. The study aims to understand how esketamine can mitigate postoperative sleep disturbances, which are common in patients undergoing surgery after neoadjuvant chemotherapy. Blood samples will also be collected to analyze potential biomarkers related to sleep and inflammation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients diagnosed with breast cancer by pathology and immunohistochemistry
2. Patients receiving neoadjuvant chemotherapy
3. Age 18 to 65 years old; d) ;
4. ASA grade Ⅰ - Ⅲ
5. BMI 18 to 30 kg/m2

Exclusion Criteria:

* 1: Patients refuse to participate in the study

  2: BMI \> 30 kg/m2

  3: Recent history of drug abuse

  4: Allergy to or contraindications to esketamine

  5: Cognitive dysfunction or inability to communicate

  6: Severe dysfunction of important organs such as liver and kidney function

Where it's running

• Nanjing First Hospital
  Nanjing, Jiangsu, China Recruiting

Study contacts

• Study coordinator: wenwen zhang, Dr
• Email: 1395626955@qq.com
• Phone: +8615366110306

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.