Transcranial Direct Current Stimulation for Long COVID with Headaches and Chronic Pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study investigates the effects of transcranial direct current stimulation (tDCS) in patients with persistent COVID-19 symptoms, focusing on headaches, migraines, chronic pain, and sleep problems. The trial includes an initial open-label phase followed by a randomized, sham-controlled, double-blind extension with four arms: anodal, bifrontal, cathodal, and sham tDCS. Enrollment aims for 27 participants in the initial phase and 60 in the extension phase, with primary outcomes unchanged and sleep measures added as secondary outcomes. Participants are adults with a confirmed past COVID-19 infection and persistent symptoms, and key exclusions include implanted devices or pregnancy. The study is conducted at the Catholic University of Valencia and affiliated sites in Valencia, Spain, under ethics approvals from the same institution.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with Persistent Covid
* Men and women
* All ages from 16 years old
* Patients who passed the Covid in its acute phase in an asymptomatic, mild and severe way.

Exclusion Criteria:

* Patients without confirmation with positive PCR in the acute phase of Covid-19
* Patients with Persistent Covid who do not have at least one of these symptoms: migraines, headaches, chronic pain, neuropathic pain, arthralgia, myalgias
* Patients with pacemaker / defibrillator
* Patients with brain implants
* Patients with cranial fractures
* Pregnant

Where it's running

• Clínica Paiporta
  Paiporta, Valencia, Spain Recruiting
• Escuela de Doctorado. Universidad Católica de Valencia San Vicente Mártir. (Doctoral School. Catholic University of Valencia San Vicente Mártir)
  Valencia, Valencia, Spain Recruiting

Study contacts

• Principal investigator: Laura García Martínez — Escuela de Doctorado. Universidad Católica de Valencia San Vicente Mártir. (Doctoral School. Catholic University of Valencia San Vicente Mártir)
• Study coordinator: Laura García Martínez
• Email: lauragarciamartinez@mail.ucv.es
• Phone: +34691635330

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.