Condition

Essential Tremor clinical trials and research

• 51Clinical trials
• 18NIH research projects
• 1New in 30 days
• 23Countries

Newest Essential Tremor clinical trials

All recruiting trials (51)

• Encora X1 in Daily Life for Essential Tremor

  This real-world study tests how the Encora X1 wrist device affects day-to-day activities for adults with essential tremor over three years.

  Recruiting Encora, Inc. · Boston, Massachusetts · NCT07911488

• Intraoperative Microelectrode Recordings with MAVEN vs Standard Equipment

  This study tests whether MAVEN can match the recording data collected during DBS surgery for movement disorders using standard equipment.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07868614

• Microelectrode-based brain stimulation for Parkinson’s and essential tremor

  This early feasibility test checks a new microelectrode-based brain stimulation method in adults with Parkinson’s disease or essential tremor who are already getting deep brain stimulation implants.

  Recruiting Lund University · Lund, Skåne County · NCT07820189

• Non-Invasive Nerve Stimulation for Essential Tremor: Long-Term Safety and Effectiveness

  This study tests whether a non-invasive stimulation device called TAPS helps reduce tremor in adults with essential tremor over a long period.

  Recruiting Ruijin Hospital · Shanghai · NCT07774598

• Low Intensity Focused Ultrasound for Essential Tremor in Adults

  This early-stage, open-label study tests whether repeated low-intensity focused ultrasound can safely and briefly modulate tremor in people with essential tremor.

  Recruiting Early Phase 1 University of California, Los Angeles · Los Angeles, California · NCT07599592

• Closed-loop TMS to reduce tremor

  This trial tries phase-locked transcranial magnetic stimulation (TMS) to reduce tremor in people with essential tremor or Parkinson's disease.

  Recruiting University of Oxford · Oxford, Oxfordshire · NCT07574164

• How deep brain stimulation affects learning and producing speech in Parkinson's disease and essential tremor

  This research will see if turning deep brain stimulation on and off changes how adults with Parkinson's disease or essential tremor learn and produce new speech sound sequences.

  Recruiting at 2 sites Boston University Charles River Campus · Boston, Massachusetts and 1 other locations · NCT07455760

• MEG to track brain changes after focused ultrasound for essential tremor

  This project uses MEG and MRI to see how high‑intensity focused ultrasound (HiFU) changes brain activity in people aged 50–84 with essential tremor who haven't responded to at least two medications.

  Recruiting University of Florida · Gainesville, Florida · NCT07446192

• Skin biopsy test for phosphorylated alpha‑synuclein to find which essential tremor patients are at risk for Parkinson's disease

  This uses a small skin biopsy (Syn‑One) to see if phosphorylated alpha‑synuclein can identify people aged 50–85 with essential tremor who are more likely to develop Parkinson's disease.

  Recruiting at 8 sites CND Life Sciences · Scottsdale, Arizona and 10 other locations · NCT07428447

• Low-intensity focused ultrasound for movement and seizure disorders

  This trial will try low-intensity focused ultrasound (LIFUS) to see if it can safely change brain activity in people with movement disorders or epilepsy.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07417280

• Dual-site transcranial magnetic stimulation targeting the supplementary motor area and cerebellum for essential tremor

  This trial will test whether five days of combined transcranial magnetic stimulation over the supplementary motor area and cerebellum can reduce tremor in adults whose essential tremor did not improve with standard medications.

  Recruiting Phase 1/2 São Paulo State University · São Paulo, São Paulo · NCT07344194

• Long-term outcomes after MRI-guided focused ultrasound thalamotomy for medication-resistant essential tremor

  This project will see if MRI-guided focused ultrasound thalamotomy provides lasting tremor relief and good long-term safety for people whose essential tremor has not responded to medications.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT07212244

• Low-intensity focused ultrasound targeting a deep brain nucleus to reduce refractory hand tremor.

  This study will try low-intensity NaviFUS-ctbTUS focused ultrasound to see if it reduces hand tremor in adults with Parkinson's disease, essential tremor, or dystonic tremor that have not improved with medication.

  Recruiting National Taiwan University Hospital · Hsinchu, Hsinchu City · NCT07172295

• Targeted mechanical stimulation used at home to relieve tremors

  This project will try a wearable device that delivers targeted mechanical stimulation at home to reduce moderate-to-severe upper limb tremors in adults with essential tremor or Parkinson's disease.

  Recruiting Encora, Inc. · Cambridge, Massachusetts · NCT07078422

• BP1.4979 to reduce essential tremor.

  See if BP1.4979, taken twice daily for four weeks, reduces tremors and is safe in adults with essential tremor.

  Recruiting at 2 sites Phase 2 Bioprojet · Amiens and 13 other locations · NCT07074002

• One‑session bilateral radiofrequency thalamotomy to reduce medication‑resistant essential tremor

  This trial will try a single‑session procedure that creates small lesions on both sides of the thalamus with radiofrequency energy to reduce disabling hand tremor in adults whose essential tremor has not improved with medicines.

  Recruiting Tokyo Women's Medical University · Shinjuku-Ku, Tokyo · NCT07066358

• Deep cerebellar nucleus stimulation for refractory tremor

  This study will try deep brain stimulation of the deep cerebellar nuclei with the Medtronic Percept RC device to reduce tremor in adults whose essential tremor, cerebellar outflow tremor, or MS-related tremor did not improve with or are not suitable for thalamic DBS or focused ultrasound.

  Recruiting Phase 1 The Cleveland Clinic · Cleveland, Ohio · NCT07049003

• Temporal interference deep brain stimulation for essential tremor

  This study will try temporal interference, a noninvasive form of deep brain stimulation, in people aged 30–70 with essential tremor to see if it reduces their tremor.

  Recruiting Xuanwu Hospital, Beijing · Beijing, Beijing Municipality · NCT07016425

• Bilateral Exablate thalamotomy for Essential Tremor

  This study is testing if a new two-sided brain procedure can help people with Essential Tremor who have already had one-sided treatment feel better compared to those who just keep taking their usual medications.

  Recruiting at 7 sites InSightec · Turku and 12 other locations · NCT06974916

• Advanced brain imaging for improving deep brain stimulation in Parkinson's and essential tremor patients

  This study is testing if advanced brain imaging can help doctors place and program deep brain stimulation better for people with Parkinson's disease and essential tremor to improve their movement.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, North Holland · NCT06932692

• How attention and eye movements affect emotion perception in Parkinson's disease

  This project will test whether deep brain stimulation changes attention, eye movements, and how people with Parkinson's disease, essential tremor, or dystonia perceive facial expressions.

  Recruiting University of Nebraska · Omaha, Nebraska · NCT06899022

• Using stereotactic radiosurgery to treat essential tremor

  This study is testing whether a special type of radiation treatment can help adults over 50 with essential tremor who haven't found relief from medications.

  Recruiting Phase 2 Maria Sklodowska-Curie National Research Institute of Oncology · Gliwice · NCT06821906

• Nighttime-adaptive deep brain stimulation for essential tremor

  We will test whether using each patient’s thalamic sleep-related brain signals to automatically turn DBS off at night can reduce side effects while keeping tremor under control in people with essential tremor who already have Medtronic Percept implants.

  Recruiting University of Florida · Gainesville, Florida · NCT06635811

• Using focused ultrasound to treat essential tremor

  This study is testing if low-intensity focused ultrasound can help reduce tremors in people with essential tremor by targeting specific areas of the brain.

  Recruiting University of California, San Francisco · San Francisco, California · NCT06610877

• Evaluating a new therapy for Parkinson's disease and essential tremor

  This study is testing a new home therapy using a special device to see if it can safely help people with Parkinson's disease or essential tremor reduce their tremors over two years.

  Recruiting Stimvia s.r.o. · Ostrava · NCT06570421

• Outcomes of radiofrequency ablation for movement disorders

  This study looks at how well a specific treatment called radiofrequency ablation works for people with movement disorders like Parkinson's disease and essential tremor.

  Recruiting at 4 sites Boston Scientific Corporation · Cologne and 3 other locations · NCT06553625

• Using 3-D imaging to improve ultrasound treatment for essential tremor

  This study is testing whether using 3-D imaging can make ultrasound treatment for essential tremor more effective for patients who haven't found relief from medication.

  Recruiting University of North Carolina, Chapel Hill · Chapel Hill, North Carolina · NCT06331052

• Bilateral thalamic stimulation for essential tremor treatment

  This study is testing a new brain stimulation treatment for people with essential tremor to see if it can safely improve their symptoms.

  Recruiting University of Toronto · Toronto, Ontario · NCT06325852

• Examining brain changes in patients with essential tremor receiving deep brain stimulation

  This study is testing how deep brain stimulation affects brain activity in people with essential tremor to find better ways to manage their symptoms.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06293638

• Using magnetic stimulation to treat essential tremor

  This study is testing if a type of magnetic stimulation can help people with essential tremor feel better by comparing it to a fake treatment.

  Recruiting Second Affiliated Hospital of Soochow University · Suzhou · NCT06145932

• Evaluating ulixacaltamide for treating essential tremor

  This study is testing if a new medication called ulixacaltamide can help people with essential tremor feel better compared to a placebo.

  Recruiting Phase 3 Praxis Precision Medicines · Morgantown, West Virginia · NCT06087276

• Comparing awake and asleep deep brain stimulation for essential tremor

  This study is testing whether deep brain stimulation done while patients are awake works better than when it's done while they're asleep for people with essential tremor who haven't found relief with medication.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, North Holland · NCT05968976

• Using advanced MRI to improve deep brain stimulation for essential tremor

  This study is testing if using advanced MRI technology can help doctors place deep brain stimulation electrodes better for people with essential tremor, aiming to improve their movement and quality of life.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, North Holland · NCT05909839

• New deep brain stimulation method for treating essential tremor

  This study is testing a new deep brain stimulation method for people with essential tremor to see if it works better than the usual treatment for shaking in the arms and hands.

  Recruiting Phase 1 University of Minnesota · Minneapolis, Minnesota · NCT05897775

• Validation of a deep learning platform for diagnosing isolated dystonia

  This study is testing a new deep learning tool to see if it can help doctors diagnose isolated dystonia more accurately and quickly.

  Recruiting Massachusetts Eye and Ear Infirmary · Boston, Massachusetts · NCT05317390

• Neurofeedback with implanted brain electrodes for neurological disorders

  This study is testing whether using real-time brain feedback from implanted electrodes can help improve symptoms in people with Parkinson's disease, epilepsy, and essential tremor.

  Recruiting ETH Zurich · Zurich, Canton of Zurich · NCT05101161

• Understanding brain networks in movement disorders

  This study tests how deep brain stimulation and medication affect brain networks in people with Parkinson's disease and essential tremor to better understand their movement problems.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT04957095

• Directional versus nondirectional deep brain stimulation for essential tremor

  This study will try directional deep brain stimulation in people with essential tremor to see if it controls tremor better and causes fewer speech, gait, or balance side effects than nondirectional DBS.

  Recruiting Oregon Health and Science University · Portland, Oregon · NCT04828798

• Understanding brain changes in essential tremor after deep brain stimulation

  This study is testing how deep brain stimulation affects brain connections in people with essential tremor who haven't found relief from medication.

  Recruiting Northwell Health · Manhasset, New York · NCT04758624

• Understanding brain activity related to speech in neurological diseases

  This study is trying to see how brain activity affects speaking in people with neurological disorders like Parkinson's disease and dystonia who are about to have deep brain stimulation surgery.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT04286308

• New approach to control severe essential tremor using advanced brain stimulation

  This study is testing a new brain stimulation device to see if it can better control severe tremors in people who haven't found relief with standard treatments.

  Recruiting University of Florida · Gainesville, Florida · NCT04212780

• Registry for patients with Essential Tremor in China

  This study is creating a registry to collect information from people with Essential Tremor in China to better understand the condition and its different forms.

  Recruiting Xiangya Hospital of Central South University · Changsha, Hunan · NCT04198246

• Long-term evaluation of Abbott deep brain stimulation systems for movement disorders

  This study is testing how safe and effective Abbott deep brain stimulation systems are for people with movement disorders like Parkinson's disease over a five-year period.

  Recruiting at 24 sites Abbott Medical Devices · Tucson, Arizona and 47 other locations · NCT04071847

• Registry of Deep Brain Stimulation for Essential Tremor

  This study is collecting information from people with Essential Tremor who are using a specific brain stimulation device to see how well it works in real life.

  Recruiting at 18 sites Boston Scientific Corporation · Innsbruck and 19 other locations · NCT04032470

• Collecting clinical outcomes for deep brain stimulation in movement disorders

  This study is tracking the experiences of people with movement disorders like Parkinson's disease who are getting deep brain stimulation to see how well it works and what risks it might have over time.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT03992625

• Using algorithms to optimize deep brain stimulation for essential tremor

  This study is testing a new way to improve deep brain stimulation for people with essential tremor by using advanced imaging to find the best settings for their treatment.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT03984643

• Evaluating deep brain stimulation for essential tremor

  This study is testing if deep brain stimulation can help people with essential tremor feel better compared to the best current medication.

  Recruiting at 5 sites Karolinska Institutet · Gothenburg and 5 other locations · NCT03832712

• Evaluating outcomes of Deep Brain Stimulation for movement disorders

  This study looks at how well Deep Brain Stimulation works for people with Parkinson's Disease, Essential Tremor, and Dystonia by reviewing past patient records.

  Recruiting at 16 sites Boston Scientific Corporation · Phoenix, Arizona and 19 other locations · NCT03664609

• Using stereotactic radiosurgery to treat essential and Parkinsonian tremors

  This study is testing if a new type of radiation treatment can help people with essential tremor or Parkinsonian tremor feel better and improve their quality of life.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT01734122

• Deep brain stimulation for movement disorders like Parkinson's disease

  This study tests whether deep brain stimulation surgery can help people with movement disorders like Parkinson's disease feel better when other treatments haven't worked.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT01581580

• Development of a brain atlas for improved treatment of neurological conditions

  This study is trying to create a detailed brain map to help doctors find the best treatment spots for patients with conditions like Parkinson's, OCD, and epilepsy.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT00575081

NIH-funded research (18)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Vocal Tremor in Essential Tremor: Understanding Physiologic Cues in Older Adults

  This grant studies why and how vocal tremor happens in people with essential tremor, aiming to better understand and describe voice changes in older adults.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11530720

• New therapies for essential tremor from cannabidiol mechanisms

  A patient-facing overview of how cannabis-based medicines might help tremor by targeting specific brain receptors, aiming to find better and better tolerated treatments for essential tremor.

  NIH research VA Greater Los Angeles Healthcare System · Los Angeles, United States · NIH-11517167

• Test to flag essential tremor patients at risk of Parkinson’s progression by detecting phosphorylated alpha-synuclein

  A new test being developed for people with essential tremor to see who might later develop Parkinson’s disease.

  NIH research Cnd Life Sciences, INC. · Scottsdale, UNITED STATES · NIH-11401181

• Clinical Pathology of Essential Tremor-Related Dementia

  A patients-facing study asks how essential tremor may be linked to dementia, with the goal of better understanding risks and potential biomarkers for people living with ET.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11366277

• Personalized tremor relief for older adults using a new tremor-decomposition tool

  A study aims to tailor tremor treatment for people 65 and older by refining a method that identifies which muscles cause tremor, with the goal of guiding practical, wearable relief options.

  NIH research Brigham Young University · Provo, United States · NIH-11348834

• PET scans to measure a brain protein (SV2A) in essential tremor

  This project uses PET brain scans to look for changes in the SV2A protein in people with essential tremor to help diagnose and follow the condition over time.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11303460

• Thalamic Coordinated Reset Deep Brain Stimulation for Essential Tremor

  A new brain stimulation approach is being tested to help people with essential tremor by using coordinated, lower-intensity stimulation to the thalamus.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11263676

• Stopping leaky calcium channels in the cerebellum for essential tremor

  This work tries to reduce tremor in people with essential tremor by correcting abnormal calcium leaks in a brain cell channel called RyR1.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11238453

• New deep brain stimulation technique for treating essential tremor

  This study is testing a new way to use deep brain stimulation to help people with essential tremor by using a gentler method that aims to reduce side effects, so you can feel better without as many complications.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11223028

• Understanding how brain connectivity changes after DBS for essential tremor

  A study of how deep brain stimulation in essential tremor patients changes brain connections over time and how this relates to long-term tremor control and side effects.

  NIH research Feinstein Institute for Medical Research · Manhasset, United States · NIH-11146409

• 3-D guided focused ultrasound for essential tremor

  This project uses 3-D tractography to guide focused ultrasound ablation of a brain target to help people whose essential tremor does not respond well to medications.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11136917

• Measuring brain proteins to understand essential tremor

  This study is looking at how a special brain protein can help doctors better understand and track essential tremor, so they can improve diagnosis and treatment for people living with this condition.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11072936

• Improving tremor control for patients with severe essential tremor using advanced brain stimulation techniques

  This study is testing a new way to help people with severe essential tremor by using a special device that stimulates two areas of the brain at once, aiming to better control tremors and reduce side effects, especially for those who haven't found relief with regular treatments.

  NIH research University of Florida · Gainesville, United States · NIH-11061909

• Mapping the brain changes in essential tremor and understanding neurodegeneration

  This study is looking at the brains of people who had essential tremor to find out how the condition affects different parts of the brain, which could help us understand it better and improve treatments for those living with it.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11023052

• Investigating calcium handling in the brain to understand essential tremor

  This study is looking into essential tremor, a condition that causes shaking, by using mice to see how changes in calcium in brain cells might be causing the tremors, with the hope of finding new treatments for people who have this condition.

  NIH research Columbia University Health Sciences · New York, United States · NIH-10991337

• New deep brain stimulation technique for treating essential tremor

  This study is testing a new way to help people with essential tremor by using a special brain stimulation technique that aims to reduce shaking while causing fewer side effects, making it a friendlier option for managing their condition.

  NIH research University of Minnesota · Minneapolis, United States · NIH-10886836

• Monitoring the effects of essential tremor on daily activities

  This study is testing a new wearable device called ETAware that helps people with essential tremor by tracking how their tremors affect daily activities, so doctors can better understand their needs and improve treatment options.

  NIH research Great Lakes Neurotechnologies · Independence, UNITED STATES · NIH-10819790

• Understanding vocal tremors in people with essential tremor

  This study is looking at what causes vocal tremors in people with essential tremor, especially how these tremors affect communication when you're feeling stressed, to help find better ways to diagnose and treat those who experience them.

  NIH research University of Utah · Salt Lake City, United States · NIH-10552587

Related topics

Quick answers

How many Essential Tremor clinical trials are recruiting right now?

51, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 23 countries. The most sites are in United States (28 trials), Germany (5 trials), Canada (4 trials), China (4 trials), Italy (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 2, Phase 2: 2, Early Phase 1: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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