Condition

Tremor clinical trials and research

• 13Clinical trials
• 36NIH research projects
• 12Countries

Newest Tremor clinical trials

All recruiting trials (13)

• MR-guided focused ultrasound thalamotomy for Parkinson's tremor

  This trial will test whether MR-guided focused ultrasound thalamotomy can provide lasting tremor control for people with Parkinson's disease whose tremor does not respond to usual dopamine medication.

  Recruiting Aarhus University Hospital · Aarhus · NCT07284719

• Deep cerebellar nucleus stimulation for refractory tremor

  This study will try deep brain stimulation of the deep cerebellar nuclei with the Medtronic Percept RC device to reduce tremor in adults whose essential tremor, cerebellar outflow tremor, or MS-related tremor did not improve with or are not suitable for thalamic DBS or focused ultrasound.

  Recruiting Phase 1 The Cleveland Clinic · Cleveland, Ohio · NCT07049003

• Using brain stimulation to reduce tremors in Parkinson's disease

  This study is testing a new brain stimulation technique to see if it can help reduce hand tremors in people with Parkinson's disease.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg, Free and Hanseatic City of Hamburg · NCT06993571

• Evaluating outcomes in neurosurgery using standardized measures

  This study is trying to see how different factors affect the results of brain surgeries by collecting information from patients before and after their operations.

  Recruiting at 11 sites Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Bergamo, BG and 26 other locations · NCT06724029

• Observational study on functional neurological disorders in movement disorder patients

  This study looks at how common functional neurological disorders are in patients with movement disorders to see how they differ from those with non-functional movement issues.

  Recruiting Medical University of Graz · Graz, Styria · NCT05943652

• Comparing Lemborexant, Zopiclone, and Clonidine for treating insomnia in chronic pain patients

  This study is testing whether Lemborexant, Zopiclone, or Clonidine can help people with chronic pain sleep better and manage their pain.

  Recruiting Salem Anaesthesia Pain Clinic · Surrey, British Columbia · NCT05618002

• Understanding movement disorders and their impact on families

  This study is gathering information from people with movement disorders like Parkinson's and their families to help improve future treatments.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05413291

• Examining brain function in laryngeal dystonia and voice tremor

  This study is testing how brain function differs in people with laryngeal dystonia and voice tremor compared to healthy individuals to better understand these voice disorders.

  Recruiting Early Phase 1 Massachusetts Eye and Ear Infirmary · Boston, Massachusetts · NCT05216770

• Evaluating voice disorders like laryngeal dystonia and voice tremor

  This study is testing new ways to tell the difference between laryngeal dystonia and voice tremor to help people get the right treatment for their voice disorders.

  Recruiting Massachusetts Eye and Ear Infirmary · Boston, Massachusetts · NCT05150106

• Deep Brain Stimulation for Voice Disorders in Dystonia and Tremor

  This study is testing if deep brain stimulation can improve voice problems in people with laryngeal dystonia and essential tremor.

  Recruiting Massachusetts Eye and Ear Infirmary · Boston, Massachusetts · NCT05150093

• Comparing two formulations of tacrolimus for liver transplant patients

  This study is testing whether a new extended-release version of tacrolimus causes fewer and less severe tremors in liver transplant patients compared to the standard immediate-release version.

  Recruiting Phase 4 University of British Columbia · Vancouver, British Columbia · NCT05089604

• Long-term evaluation of Abbott deep brain stimulation systems for movement disorders

  This study is testing how safe and effective Abbott deep brain stimulation systems are for people with movement disorders like Parkinson's disease over a five-year period.

  Recruiting at 24 sites Abbott Medical Devices · Tucson, Arizona and 47 other locations · NCT04071847

• Using stereotactic radiosurgery to treat essential and Parkinsonian tremors

  This study is testing if a new type of radiation treatment can help people with essential tremor or Parkinsonian tremor feel better and improve their quality of life.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT01734122

NIH-funded research (36)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Vocal Tremor in Essential Tremor: Understanding Physiologic Cues in Older Adults

  This grant studies why and how vocal tremor happens in people with essential tremor, aiming to better understand and describe voice changes in older adults.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11530720

• New therapies for essential tremor from cannabidiol mechanisms

  A patient-facing overview of how cannabis-based medicines might help tremor by targeting specific brain receptors, aiming to find better and better tolerated treatments for essential tremor.

  NIH research VA Greater Los Angeles Healthcare System · Los Angeles, United States · NIH-11517167

• Test to flag essential tremor patients at risk of Parkinson’s progression by detecting phosphorylated alpha-synuclein

  A new test being developed for people with essential tremor to see who might later develop Parkinson’s disease.

  NIH research Cnd Life Sciences, INC. · Scottsdale, UNITED STATES · NIH-11401181

• Next-generation clinical profiling for laryngeal dystonia and voice tremor

  A multi-site program is exploring what makes laryngeal dystonia and voice tremor different from other conditions, aiming to improve diagnosis and targeted treatments for people affected by these voice disorders.

  NIH research Massachusetts Eye and Ear Infirmary · Boston, United States · NIH-11389177

• Clinical Pathology of Essential Tremor-Related Dementia

  A patients-facing study asks how essential tremor may be linked to dementia, with the goal of better understanding risks and potential biomarkers for people living with ET.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11366277

• m6A RNA modifications and FXTAS: uncovering new paths to treatment

  A small, patient-focused study will explore how a brain RNA modification called m6A may influence the progression of Fragile X-associated tremor/ataxia syndrome (FXTAS) and point toward new treatment ideas.

  NIH research Emory University · Atlanta, United States · NIH-11356174

• Personalized tremor relief for older adults using a new tremor-decomposition tool

  A study aims to tailor tremor treatment for people 65 and older by refining a method that identifies which muscles cause tremor, with the goal of guiding practical, wearable relief options.

  NIH research Brigham Young University · Provo, United States · NIH-11348834

• PET scans to measure a brain protein (SV2A) in essential tremor

  This project uses PET brain scans to look for changes in the SV2A protein in people with essential tremor to help diagnose and follow the condition over time.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11303460

• Thalamic Coordinated Reset Deep Brain Stimulation for Essential Tremor

  A new brain stimulation approach is being tested to help people with essential tremor by using coordinated, lower-intensity stimulation to the thalamus.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11263676

• Tracking changes and causes of Fragile X-associated tremor/ataxia syndrome (FXTAS)

  Researchers will follow people who carry FMR1 premutations—some with FXTAS, some without, and healthy volunteers—over two years to find brain, movement, and molecular markers linked to disease changes.

  NIH research University of Kansas Lawrence · Lawrence, United States · NIH-11239018

• Stopping leaky calcium channels in the cerebellum for essential tremor

  This work tries to reduce tremor in people with essential tremor by correcting abnormal calcium leaks in a brain cell channel called RyR1.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11238453

• Targeted thalamus stimulation to reduce voice tremor

  Seeing if targeted deep brain stimulation of a thalamus region can reduce voice tremor in people with essential tremor.

  NIH research University of Florida · Gainesville, United States · NIH-11237070

• New deep brain stimulation technique for treating essential tremor

  This study is testing a new way to use deep brain stimulation to help people with essential tremor by using a gentler method that aims to reduce side effects, so you can feel better without as many complications.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11223028

• Deep brain stimulation to improve voice in laryngeal dystonia and voice tremor

  Researchers will record brain activity during and before DBS surgery to learn how stimulation changes voice control in people with laryngeal dystonia or voice tremor.

  NIH research Massachusetts Eye and Ear Infirmary · Boston, United States · NIH-11161200

• Brain causes of vocal spasms (laryngeal dystonia) and voice tremor

  This project uses advanced brain imaging while people speak to find when and where brain activity goes wrong in laryngeal dystonia and voice tremor.

  NIH research Massachusetts Eye and Ear Infirmary · Boston, United States · NIH-11161199

• Telling strained voices apart from shaky voices to improve diagnosis

  This project looks for clear voice and clinical features to help people with strained, stopped, or shaky speech get the right diagnosis faster.

  NIH research Massachusetts Eye and Ear Infirmary · Boston, United States · NIH-11161197

• Understanding voice spasms and tremors (laryngeal dystonia and voice tremor)

  This program will map patterns and causes of voice spasms and tremors to help people with laryngeal dystonia or voice tremor get more accurate diagnoses and better treatments.

  NIH research Massachusetts Eye and Ear Infirmary · Boston, United States · NIH-11161195

• Understanding how brain connectivity changes after DBS for essential tremor

  A study of how deep brain stimulation in essential tremor patients changes brain connections over time and how this relates to long-term tremor control and side effects.

  NIH research Feinstein Institute for Medical Research · Manhasset, United States · NIH-11146409

• 3-D guided focused ultrasound for essential tremor

  This project uses 3-D tractography to guide focused ultrasound ablation of a brain target to help people whose essential tremor does not respond well to medications.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11136917

• Measuring brain proteins to understand essential tremor

  This study is looking at how a special brain protein can help doctors better understand and track essential tremor, so they can improve diagnosis and treatment for people living with this condition.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11072936

• Improving tremor control for patients with severe essential tremor using advanced brain stimulation techniques

  This study is testing a new way to help people with severe essential tremor by using a special device that stimulates two areas of the brain at once, aiming to better control tremors and reduce side effects, especially for those who haven't found relief with regular treatments.

  NIH research University of Florida · Gainesville, United States · NIH-11061909

• Mapping the brain changes in essential tremor and understanding neurodegeneration

  This study is looking at the brains of people who had essential tremor to find out how the condition affects different parts of the brain, which could help us understand it better and improve treatments for those living with it.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11023052

• Understanding disease progression in Fragile X-associated tremor/ataxia syndrome (FXTAS)

  This study is looking for ways to better understand and track the progression of Fragile X-associated tremor/ataxia syndrome (FXTAS) in older adults, and it’s inviting people with FXTAS, those who carry the gene but aren’t showing symptoms, and healthy individuals to participate over two years.

  NIH research University of Kansas Lawrence · Lawrence, United States · NIH-11015811

• Improving treatment for voice tremors in people with essential tremor

  This study is looking at how deep brain stimulation can help people with essential voice tremor feel better and communicate more easily by finding the best spot in the brain to target for treatment.

  NIH research University of Florida · Gainesville, United States · NIH-10999473

• Investigating calcium handling in the brain to understand essential tremor

  This study is looking into essential tremor, a condition that causes shaking, by using mice to see how changes in calcium in brain cells might be causing the tremors, with the hope of finding new treatments for people who have this condition.

  NIH research Columbia University Health Sciences · New York, United States · NIH-10991337

• Using deep brain stimulation to improve voice control in patients with movement disorders

  This study is looking at how a treatment called deep brain stimulation can help people with movement disorders, like laryngeal dystonia and essential tremor, improve their voice control while they talk, so they can better understand how the brain affects voice production and find new ways to help those struggling with

  NIH research Massachusetts Eye and Ear Infirmary · Boston, United States · NIH-10915599

• Exploring brain function in voice disorders like laryngeal dystonia and voice tremor

  This study is looking at how the brain helps people with laryngeal dystonia and voice tremor speak, using special brain scans to find out what’s happening in their brains during speech, so we can better understand these conditions and improve treatment options for those affected.

  NIH research Massachusetts Eye and Ear Infirmary · Boston, United States · NIH-10915598

• Understanding voice disorders like laryngeal dystonia and voice tremor

  This study is looking at two uncommon voice disorders, laryngeal dystonia and voice tremor, to help doctors better understand and diagnose them, so that people with these conditions can get the right treatment faster.

  NIH research Massachusetts Eye and Ear Infirmary · Boston, United States · NIH-10915596

• Understanding and improving treatment for laryngeal dystonia and voice tremor

  This study is looking into laryngeal dystonia and voice tremor to better understand how they affect speech and daily life, with the goal of improving diagnosis and treatment for people dealing with these conditions.

  NIH research Massachusetts Eye and Ear Infirmary · Boston, United States · NIH-10915594

• Investigating mutations in a protein linked to muscle weakness and tremors

  This study is looking at how changes in a specific protein called Myosin Binding Protein-C can lead to muscle problems like weakness and tremors, and it aims to help patients by figuring out how these changes affect muscle function and finding new ways to treat these issues.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-10908598

• New deep brain stimulation technique for treating essential tremor

  This study is testing a new way to help people with essential tremor by using a special brain stimulation technique that aims to reduce shaking while causing fewer side effects, making it a friendlier option for managing their condition.

  NIH research University of Minnesota · Minneapolis, United States · NIH-10886836

• Investigating how sex and estrogen affect Parkinson's disease and related cognitive impairments in mice.

  This study is looking at how differences between men and women, along with the hormone estrogen, affect the progression of Parkinson's disease and Dementia with Lewy bodies, using special mouse models to find new ways to help treat these conditions.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-10880982

• Investigating how brain connections in the cerebellum affect tremors

  This study is looking at how certain brain connections might affect the worsening of essential tremor in people over 40, with the hope of finding new ways to help manage the condition.

  NIH research Columbia University Health Sciences · New York, United States · NIH-10843910

• Monitoring the effects of essential tremor on daily activities

  This study is testing a new wearable device called ETAware that helps people with essential tremor by tracking how their tremors affect daily activities, so doctors can better understand their needs and improve treatment options.

  NIH research Great Lakes Neurotechnologies · Independence, UNITED STATES · NIH-10819790

• Improving smartphone use for people with hand tremors

  This study is testing a new software that helps people with hand tremors use their smartphones and other devices more easily, making everyday tasks simpler and improving their quality of life.

  NIH research Minnesota Healthsolutions Corporation · Saint Paul, United States · NIH-10695531

• Understanding vocal tremors in people with essential tremor

  This study is looking at what causes vocal tremors in people with essential tremor, especially how these tremors affect communication when you're feeling stressed, to help find better ways to diagnose and treat those who experience them.

  NIH research University of Utah · Salt Lake City, United States · NIH-10552587

Related topics

Quick answers

How many Tremor clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (7 trials), Germany (2 trials), Italy (2 trials), Canada (2 trials), Australia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 1, Early Phase 1: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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