Clinical Pathology of Essential Tremor-Related Dementia

Who could benefit from this research

What this research studies

This grant funds a long-term study of older adults with essential tremor to understand how cognitive decline and dementia may develop in this group. It builds on prior work by following participants over time and analyzing brain tissue after death to identify what tissues and biomarkers are associated with ET-related dementia. The approach combines clinical assessments, neuropsychology tests, imaging data, and postmortem neuropathology to map how ET progresses to cognitive impairment. The findings could help doctors recognize dementia risk earlier and guide future therapies for people with ET who may be at higher risk. Overall, the project aims to fill crucial gaps in how ET relates to dementia and its underlying biology.

Why it matters

Where this research is happening

• Ut Southwestern Medical Center
  Dallas, United States Active

Researchers

• Principal investigator: Louis, Elan D — Ut Southwestern Medical Center
• Study coordinator: Louis, Elan D

Related research

Other NIH-funded projects on the same topics.

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  NIH research Brigham Young University · Provo, United States · NIH-11348834

• PET scans to measure a brain protein (SV2A) in essential tremor

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• Thalamic Coordinated Reset Deep Brain Stimulation for Essential Tremor

  A new brain stimulation approach is being tested to help people with essential tremor by using coordinated, lower-intensity stimulation to the thalamus.

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.