Mapping the brain changes in essential tremor and understanding neurodegeneration
Deep Dive: Mapping the Neuropathology of Essential Tremor and Exploring the Molecular Underpinnings of Neurodegeneration
This study is looking at the brains of people who had essential tremor to find out how the condition affects different parts of the brain, which could help us understand it better and improve treatments for those living with it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11023052 on NIH RePORTER |
What this research studies
This research investigates essential tremor, a common neurological disorder affecting millions, by examining the brain tissue of individuals who had the condition. The team has established a comprehensive brain repository and is conducting detailed postmortem studies to identify specific patterns of degeneration in the cerebellum and other brain regions. By analyzing the connections within the brain's tremor circuits, the research aims to uncover the underlying mechanisms of the disease, which could lead to better understanding and treatment options for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with essential tremor, particularly those who may be willing to donate their brain tissue postmortem.
Not a fit: Patients with essential tremor who are not willing to participate in brain donation or those with other neurological disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment strategies for individuals suffering from essential tremor.
How similar studies have performed: Previous research has shown promising results in understanding other neurodegenerative diseases through postmortem brain analysis, suggesting potential for success in this novel approach.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Faust, Phyllis L — Columbia University Health Sciences
- Study coordinator: Faust, Phyllis L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.