Advanced brain imaging for improving deep brain stimulation in Parkinson's and essential tremor patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to enhance the effectiveness of deep brain stimulation (DBS) for patients with Parkinson's disease and essential tremor by utilizing advanced imaging techniques, specifically 7-Tesla MRI and magnetoencephalography (MEG). The researchers will analyze brain networks to improve electrode placement and programming of DBS, which could lead to better patient-specific treatment outcomes. By focusing on the intricate motor networks within the brain, the study seeks to address the limitations of current DBS methods that rely on lower-resolution imaging. The goal is to achieve more significant motor improvements for patients who currently experience insufficient benefits from DBS.

Why it matters

Who can join: the full rules

Inclusion Criteria:

In order to be eligible to participate in this study, a subject must meet all of the following criteria:

* Age \> 18 years;
* Idiopathic PD/ET with at least six months of DBS
* Underwent a preoperative 7-Tesla MRI scan

Exclusion Criteria:

A potential subject who meets any of the following criteria will be excluded from participation in this study:

* Legally incompetent adults;
* No written informed consent.
* A spinal stimulation or deep brain stimulation system is not compatible with 7-Tesla MRI
* There a no implants inadmissible in the MEG, although patients will be questioned for possible (non-removable) implants such as pacemakerand/or dental as they may interfere with the magnetic signals

Where it's running

• Amsterdam UMC
  Amsterdam, North Holland, Netherlands Recruiting

Study contacts

• Study coordinator: Maarten Bot Bot, MD PhD
• Email: m.bot@amsterdamumc.nl
• Phone: 0031621514048

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.