Understanding brain networks in movement disorders
Motor Network Physiology Characterization During Deep Brain Stimulation Surgery
This study tests how deep brain stimulation and medication affect brain networks in people with Parkinson's disease and essential tremor to better understand their movement problems.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 120 (estimated) |
| Ages | 18 Years to 89 Years |
| Sex | All |
| Sponsor | University of Texas Southwestern Medical Center Academic / other |
| Locations | 1 site (Dallas, Texas) |
| Trial ID | NCT04957095 on ClinicalTrials.gov |
What this trial studies
This study investigates the brain networks involved in movement control, particularly in patients with Parkinson's disease and essential tremor. It aims to explore how deep brain stimulation and levodopa medication affect these networks and their relationship to disease symptoms. By analyzing the dynamics of the basal ganglia thalamocortical circuit, the research seeks to develop a unified theory that explains the rigidity and bradykinesia associated with Parkinson's disease. Participants will undergo awake deep brain stimulation to gather data on brain function during movement.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with Parkinson's disease who are recommended for deep brain stimulation to manage their movement disorder.
Not a fit: Patients with significant cognitive deficits or recent use of anticoagulant medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for movement disorders, enhancing patient quality of life.
How similar studies have performed: Other studies have shown promise in using deep brain stimulation for movement disorders, suggesting that this approach may yield valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of Parkinson's disease who have been recommended to undergo deep brain stimulation for management of their movement disorder * Preoperative MRI without evidence of cortical or subdural adhesions or vascular abnormalities * Willingness and ability to cooperate during conscious operative procedure for up to 40 minutes Exclusion Criteria: * Patients with recent use (within one week) of anticoagulant or antiplatelet agents * Neurocognitive testing indicating amnestic cognitive deficits
Where this trial is running
Dallas, Texas
- UT Southwestern Medical Center — Dallas, Texas, United States (Recruiting)
Study contacts
- Principal investigator: Nader Pouratian, MD, PhD — University of Texas Southwestern Medical Center
- Study coordinator: Nader Pouratian, MD, PhD
- Email: nader.pouratian@utsouthwestern.edu
- Phone: (214)645-5465
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.