MEG to track brain changes after focused ultrasound for essential tremor

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional pilot follows participants for about eight months with six in-person visits, including a screening, a pre-treatment assessment, and post-treatment follow-ups at 1 day, 6 weeks, and 6 months. Participants receive HiFU treatment for tremor and undergo non-invasive brain imaging with magnetoencephalography (MEG) and functional MRI (fMRI), along with sensor-based motor assessments and self-report questionnaires. The study compares brain network activity and motor function before and after treatment to identify how HiFU alters neural circuits linked to tremor. Data are collected at a single site (UF Health, Gainesville) using standardized imaging and motor testing protocols.

Why it matters

Who can join: the full rules

Inclusion:

* Age \>50 years and \<85 years
* Refractory to at least 2 first line tremor medications
* Skull Density Ratio (SDR) \> = 0.35

Exclusion:

* MR/MEG incompatible implants and implantable devices (ex: pacemaker)
* Head tremor interfering with MEG recording
* Severe depression and/or anxiety
* Severe cognitive impairment

Where it's running

• UF Health
  Gainesville, Florida, United States Recruiting

Study contacts

• Principal investigator: Justin Hilliard, MD — University of Florida
• Study coordinator: Kerstin Rodriguez, CCMA, CPT
• Email: Kerstin.Rodriguez@neurosurgery.ufl.edu
• Phone: 352-273-9000

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Encora X1 in Daily Life for Essential Tremor

  This real-world study tests how the Encora X1 wrist device affects day-to-day activities for adults with essential tremor over three years.

  Recruiting Encora, Inc. · Boston, Massachusetts · NCT07911488

• Intraoperative Microelectrode Recordings with MAVEN vs Standard Equipment

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  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07868614

• Microelectrode-based brain stimulation for Parkinson’s and essential tremor

  This early feasibility test checks a new microelectrode-based brain stimulation method in adults with Parkinson’s disease or essential tremor who are already getting deep brain stimulation implants.

  Recruiting Lund University · Lund, Skåne County · NCT07820189

• Non-Invasive Nerve Stimulation for Essential Tremor: Long-Term Safety and Effectiveness

  This study tests whether a non-invasive stimulation device called TAPS helps reduce tremor in adults with essential tremor over a long period.

  Recruiting Ruijin Hospital · Shanghai · NCT07774598

• Low Intensity Focused Ultrasound for Essential Tremor in Adults

  This early-stage, open-label study tests whether repeated low-intensity focused ultrasound can safely and briefly modulate tremor in people with essential tremor.

  Recruiting Early Phase 1 University of California, Los Angeles · Los Angeles, California · NCT07599592

• Closed-loop TMS to reduce tremor

  This trial tries phase-locked transcranial magnetic stimulation (TMS) to reduce tremor in people with essential tremor or Parkinson's disease.

  Recruiting University of Oxford · Oxford, Oxfordshire · NCT07574164

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.