Investigating calcium handling in the brain to understand essential tremor
Targeting Cerebellar Endoplasmic Reticulum Calcium Handling in Essential Tremor
This study is looking into essential tremor, a condition that causes shaking, by using mice to see how changes in calcium in brain cells might be causing the tremors, with the hope of finding new treatments for people who have this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10991337 on NIH RePORTER |
What this research studies
This research focuses on essential tremor (ET), a common and progressive movement disorder that affects many individuals. The study aims to understand the underlying mechanisms of ET by examining changes in calcium handling within brain cells, particularly in the cerebellum. Researchers are utilizing a mouse model that mimics the condition to explore how abnormal calcium signaling contributes to tremors. By identifying these mechanisms, the research seeks to pave the way for new therapeutic options for patients suffering from ET.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with essential tremor, particularly those experiencing progressive symptoms.
Not a fit: Patients with tremors caused by other conditions, such as Parkinson's disease or those without a diagnosis of essential tremor, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for essential tremor, potentially reducing symptoms and enhancing the quality of life for patients.
How similar studies have performed: Previous research has shown promising results in understanding calcium handling in other neurological disorders, suggesting potential for success in this area as well.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Kuo, Sheng-Han — Columbia University Health Sciences
- Study coordinator: Kuo, Sheng-Han
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.