Condition

Deep Brain Stimulation clinical trials and research

• 30Clinical trials
• 114NIH research projects
• 9Countries

Newest Deep Brain Stimulation clinical trials

All recruiting trials (30)

• How physical activity might help people with Parkinson’s disease who have DBS-STN implants

  This study tests whether adding regular physical activity can help people with Parkinson’s who have DBS-STN stimulation by trying a structured physiotherapy approach alongside standard care.

  Recruiting Medical University of Warsaw · Warsaw · NCT07838636

• See if deep brain stimulation for Parkinson's changes thinking and movement and affects fall risk

  This pilot study tests whether deep brain stimulation in people with Parkinson’s changes thinking or movement and whether those changes relate to how often they fall.

  Recruiting University of Alabama at Birmingham · Homewood, Alabama · NCT07725315

• How aerobic exercise (forced vs voluntary cycling) affects movement, thinking, and brain signals in people with Parkinson’s and deep brain stimulation

  This study tests whether forced or voluntary cycling improves movement, thinking, and brain activity in people with Parkinson’s who already have a DBS device.

  Recruiting Phase 2 The Cleveland Clinic · Cleveland, Ohio · NCT07442747

• Low-intensity focused ultrasound for movement and seizure disorders

  This trial will try low-intensity focused ultrasound (LIFUS) to see if it can safely change brain activity in people with movement disorders or epilepsy.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07417280

• Patterned deep brain stimulation delivered at home for Parkinson's

  This study will test whether three types of patterned deep brain stimulation can be used safely and comfortably at home in people with Parkinson's who already have stable bilateral STN or GPi Boston Scientific DBS systems.

  Recruiting University of Florida · Gainesville, Florida · NCT07410598

• Blood-based predictors of DBS outcomes for Parkinson's disease

  This project will test whether proteins and RNA in blood can predict how people with Parkinson's disease will respond to deep brain stimulation (DBS).

  Recruiting Hong Kong University of Science and Technology · Hong Kong · NCT07376278

• Measuring brain network activity to predict and improve outcomes in children with dystonia

  This project will test whether noninvasive brain and muscle recordings, and comparing DBS on versus off, can predict and help improve motor outcomes for children with dystonia.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT07325175

• Buntanetap for people with Parkinson's disease

  This 36-month open-label trial will try buntanetap 30 mg once daily in people with Parkinson's disease, including those with deep brain stimulation or who previously received buntanetap, to see if it is safe long-term.

  Recruiting at 28 sites Phase 2/3 Annovis Bio Inc. · Birmingham, Alabama and 28 other locations · NCT07284784

• Mediterranean diet for managing weight and body composition after bilateral subthalamic nucleus deep brain stimulation in Parkinson's disease

  It will see if following a Mediterranean diet for three months after bilateral subthalamic nucleus deep brain stimulation helps adults with Parkinson's control weight and improve body composition.

  Recruiting Ankara University · Ankara, Ankara · NCT07187739

• Deep brain stimulator battery replacement for people with Parkinson's disease

  This trial tests whether having a DBS battery replacement under regional chest-wall nerve blocks works as well and is as safe as having it under general anesthesia for people with Parkinson's disease aged 40–85.

  Recruiting Ankara Etlik City Hospital · Ankara, Yenimahalle\Ankara · NCT07176494

• Scalp EEG mapping of DBS-induced electric fields

  This will test whether very high–sampling-rate EEG can record the electric fields produced by DBS in people with Parkinson's disease or related movement disorders who already have implants.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg · NCT07115394

• Frequency-specific stimulation of subthalamic nucleus subregions to improve inhibitory control in Parkinson's disease

  This tests whether stimulating different parts of the subthalamic nucleus at low (5 Hz) or high (130 Hz) frequencies can improve inhibitory control in people with Parkinson's disease who have deep brain stimulation.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07022522

• How deep brain stimulation affects thinking and memory in Parkinson's

  This project will use MRI scans to see if subthalamic nucleus deep brain stimulation (DBS) changes brain networks and relates to thinking or memory declines in people with Parkinson's disease who already have DBS implants.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06960096

• Understanding how Deep Brain Stimulation affects Freezing of Gait in Parkinson's Disease

  This study is testing how Deep Brain Stimulation can help people with Parkinson's Disease who struggle with Freezing of Gait by looking at their brain and behavior before and after the treatment.

  Recruiting Phase 4 Medical University of South Carolina · Charleston, South Carolina · NCT06951906

• Advanced brain imaging for improving deep brain stimulation in Parkinson's and essential tremor patients

  This study is testing if advanced brain imaging can help doctors place and program deep brain stimulation better for people with Parkinson's disease and essential tremor to improve their movement.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, North Holland · NCT06932692

• Investigating how deep brain stimulation affects sleep in Parkinson's disease

  This study is testing how deep brain stimulation affects sleep in people with Parkinson's disease to see if it can help improve their sleep quality.

  Recruiting Xuanwu Hospital, Beijing · Beijing, Beijing Municipality · NCT06914466

• Adaptive versus continuous subthalamic nucleus deep brain stimulation for people with Parkinson's

  This project will try adaptive DBS versus regular continuous DBS in people with Parkinson's who already have Medtronic Percept STN implants to see if one gives more daily ON time without troublesome dyskinesia over six months.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Leuven and 3 other locations · NCT06909045

• Personalized deep brain stimulation for Tourette syndrome

  This study is testing if personalized deep brain stimulation can help people with Tourette syndrome reduce their tics and improve related issues like anxiety and attention problems.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT06889480

• Investigating non-invasive brain stimulation for drug-resistant epilepsy

  This study is testing a new non-invasive brain stimulation method to see if it can help people aged 14-60 with epilepsy that doesn't respond to medication.

  Recruiting Xuanwu Hospital, Beijing · Beijing, Beijing Municipality · NCT06663969

• Registry for pediatric deep brain stimulation outcomes

  This study is creating a database to collect information on how deep brain stimulation helps children with movement disorders like dystonia and Tourette syndrome, to see how safe and effective the treatment is.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT06585618

• Deep brain stimulation for treatment-resistant mental disorders

  This study is testing a new brain stimulation treatment for people with severe mental disorders like OCD and schizophrenia to see if it can help them feel better.

  Recruiting Shanghai Mental Health Center · Shanghai · NCT06112067

• Comparing awake and asleep deep brain stimulation for essential tremor

  This study is testing whether deep brain stimulation done while patients are awake works better than when it's done while they're asleep for people with essential tremor who haven't found relief with medication.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, North Holland · NCT05968976

• Deep brain stimulation therapy for sleep issues in Parkinson's disease

  This study is testing if deep brain stimulation can help people with Parkinson's disease improve their sleep problems.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05962489

• Using advanced MRI to improve deep brain stimulation for Parkinson's disease

  This study is testing if using advanced MRI technology can help improve deep brain stimulation for people with advanced Parkinson's disease by better targeting the brain areas that control movement.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, North Holland · NCT05843084

• Understanding brain connectivity in Parkinson's disease and deep brain stimulation

  This study is trying to see how deep brain stimulation affects brain connections in people with Parkinson's disease to improve their treatment and help with movement and thinking.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05568199

• Optimizing brain stimulation for epilepsy treatment

  This study is testing if adjusting the settings of brain stimulation devices can help people with hard-to-treat epilepsy have fewer seizures.

  Recruiting Early Phase 1 University of Minnesota · Minneapolis, Minnesota · NCT05493722

• Comparing two types of deep brain stimulation for craniofacial dystonia

  This study is testing whether a new type of brain stimulation can help people with craniofacial dystonia feel better compared to a standard method after a year.

  Recruiting Beijing Tiantan Hospital · Beijing · NCT05416905

• CereGate Therapy for Freezing of Gait in Parkinson's Disease

  This study is testing if CereGate therapy can help people with Parkinson's Disease who have freezing of gait feel more mobile and improve their movement after having deep brain stimulation.

  Recruiting at 7 sites CereGate Inc. · Redwood City, California and 6 other locations · NCT05292794

• Image-guided programming for deep brain stimulation in dystonia

  This study is testing a new way to program deep brain stimulation for people with dystonia to see if it can improve their treatment results.

  Recruiting Wuerzburg University Hospital · Würzburg, Bavaria · NCT05097001

• Understanding motivation in Parkinson's patients using neurophysiology

  This study is testing how a brain device affects motivation and decision-making in people with Parkinson's disease while they do tasks that involve rewards.

  Recruiting University of California, San Francisco · San Francisco, California · NCT05065151

NIH-funded research (newest 40 of 114)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Cerebellar Deep Brain Stimulation for Spinocerebellar Ataxias

  A preliminary clinical trial will test delivering electrical stimulation to the cerebellum in people with spinocerebellar ataxia to see if it improves balance and coordination.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11602642

• Improving deep brain stimulation with MRI and AI

  We use brain scans and artificial intelligence to speed up and personalize deep brain stimulation settings for people getting DBS.

  NIH research Ge Medical Systems Information Technologies, INC · Niskayuna, United States · NIH-11478774

• Adaptive deep brain stimulation to help Parkinson's patients respond to daily changes

  A new, smarter brain stimulation approach for Parkinson’s disease aims to automatically adjust therapy throughout the day to better control symptoms.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11472896

• Automated programming for personalized deep brain stimulation in Parkinson’s disease

  Aims to create an AI-powered system that automatically tunes the brain stimulation settings for people with Parkinson’s disease to improve benefits and reduce side effects.

  NIH research Emory University · Atlanta, United States · NIH-11450554

• Ventral pallidum brain stimulation for epilepsy

  A brain stimulation therapy in people with epilepsy whose seizures aren’t controlled by medicines or surgery is being studied to see if it can help achieve seizure freedom.

  NIH research University of Louisville · Louisville, United States · NIH-11450530

• TinyML-powered closed-loop DBS for Parkinson's disease

  A small, energy-efficient brain-stimulation system using lightweight AI runs on an implanted device to adapt DBS in real time for people with Parkinson's disease.

  NIH research Michigan Technological University · Houghton, United States · NIH-11444690

• Neuronal signals guiding deep brain stimulation for neuropsychiatric disorders

  A doctor-scientist at Stanford plans to study how deep brain stimulation changes brain cells and circuits in people with OCD, depression, and movement disorders to improve how DBS therapies work.

  NIH research Stanford University · Stanford, United States · NIH-11438671

• Adaptive Deep Brain Stimulation for Parkinson's Disease

  A safety-focused study tests a new brain-stimulation device that could tailor therapy for people with Parkinson’s by adapting stimulation based on brain signals and sleep stages.

  NIH research University of Florida · Gainesville, United States · NIH-11424885

• Deep Brain Stimulation for Chronic Low Back Pain

  A new brain-targeted therapy is tested to help people with long-standing, hard-to-treat low back pain that hasn’t improved with other treatments.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11417113

• Understanding how deep-brain stimulation affects stopping movement in Parkinson’s disease

  This grant tests how stimulating a brain region used to treat Parkinson’s might change a person’s ability to stop moving quickly.

  NIH research University of Iowa · Iowa City, United States · NIH-11412473

• Automated DBS programming to improve Parkinson’s care at home and clinic

  A new software tool helps doctors and patients set deep brain stimulation parameters for movement disorders like Parkinson’s disease more quickly and accurately, in clinics or at home.

  NIH research Great Lakes Neurotechnologies · Independence, UNITED STATES · NIH-11398197

• Theta Burst Deep Brain Stimulation for Cognitive and Motor Benefits in Parkinson’s-Related Dementia

  A study from USC will test a new brain stimulation approach to help people with Parkinson’s disease and Lewy body dementia improve thinking skills and movement.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11396247

• Closed-loop Deep Brain Stimulation for Disrupting Abnormal Brain Signals in Alzheimer’s Disease

  This grant funds research to test a smart, responsive brain stimulation approach to help people with Alzheimer’s-related brain changes feel fewer symptoms.

  NIH research San Jose State University · San Jose, United States · NIH-11393673

• Mood-state classifiers to guide brain stimulation for treatment-resistant bipolar depression

  This project tests a brain stimulation therapy combined with wearable and smartphone data to help people with treatment-resistant bipolar depression regain mood stability.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11392518

• Imaging clues to how deep brain stimulation helps freezing of gait in Parkinson’s

  This study uses brain imaging to understand why deep brain stimulation helps or doesn’t help freezing of gait in people with Parkinson’s disease.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11389591

• Post-trial access and ongoing care for people with implanted brain stimulation devices

  This grant explores how to help people who received deep brain stimulation keep benefiting from the devices after trials end, including care, support, and navigation of new life with the technology.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11382327

• Effects of DBS on voice, swallowing, and coughing in Parkinson’s disease

  This grant tests how deep brain stimulation targeting different brain regions affects voice, swallowing, and coughing in people with Parkinson’s disease.

  NIH research University of Florida · Gainesville, United States · NIH-11381806

• Studying how deep brain stimulation helps Rett syndrome in mice

  Researchers are testing how deep brain stimulation affects brain cells and memory in a mouse model of Rett syndrome to uncover mechanisms that could guide future therapies.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11380840

• Calcium imaging guides deep brain stimulation to boost chronic stroke recovery in a rat model

  A research team is testing how customizing deep brain stimulation parameters in rats with stroke can improve long-term motor recovery, with the goal of guiding future patient treatments.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11377407

• Optical voltage imaging to understand how deep brain stimulation works

  A research study will use advanced imaging to reveal how deep brain stimulation changes brain cells and networks in people with brain disorders.

  NIH research Boston University (Charles River Campus) · Boston, United States · NIH-11377255

• Using deep brain stimulation to study how the parietal cortex supports memory in people

  A research team is exploring how deep brain stimulation in the parietal cortex affects the brain signals involved in forming and recalling memories in people with memory-related conditions.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11362439

• Spatiotemporal Tuning of Deep Brain Stimulation for Parkinson’s Disease

  Aims to personalize deep brain stimulation by adjusting where and when the brain is stimulated to better control Parkinson’s symptoms.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11362362

• Targeted deep brain stimulation to reduce infantile epilepsy spasms

  This project will see if tiny electrical pulses delivered to specific deep brain areas can reduce severe infantile spasms, first in animal models to help design future treatments for babies.

  NIH research New York Medical College · Valhalla, United States · NIH-11354757

• Understanding sleep problems in Parkinson’s disease using at-home brain recordings and adaptive stimulation

  Scientists are testing how brain signals during sleep relate to sleep problems in Parkinson’s and whether a special DBS device at home can improve sleep by adapting stimulation.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11330586

• Connectomic Deep Brain Stimulation for Obsessive-Compulsive Disorder

  This project studies how targeting brain networks with DBS could improve symptoms for people with OCD who don’t respond to standard treatments.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11323974

• Cerebellum-targeted deep brain stimulation for severe movement problems and spasticity in cerebral palsy

  This project tests whether implanted electrodes that stimulate a cerebellar motor area can reduce severe involuntary movements and muscle tightness in children and young adults with cerebral palsy.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11322723

• How Parkinson's and deep brain stimulation change brain circuits that control sleep and wakefulness

  This project looks at how Parkinson's disease and different deep brain stimulation targets change the brain circuits that control sleep for people with PD who struggle with sleep problems.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11322070

• Finding the brain circuit behind focal epilepsy using lesions and deep brain stimulation

  This project uses patterns of brain injury and responses to deep brain stimulation to find the brain circuit that causes and treats focal epilepsy in people with lesions from stroke, trauma, or tumors.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11307081

• Subthalamic Deep Brain Stimulation to Help with Visuo-Vestibular Conflicts in Parkinson's

  A study to improve how people with Parkinson's use visual and balance cues when moving, by optimizing deep brain stimulation in the subthalamic nucleus to help navigation and balance.

  NIH research Cleveland VA Medical Research/ed/fdn · Cleveland, United States · NIH-11304149

• Continuing care and support after deep brain stimulation

  This project is working to make sure people who get experimental deep brain stimulation can keep getting device care, medical follow-up, and psychosocial support after their research participation ends.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11302830

• Deep brain stimulation to improve visual search in Parkinson’s disease

  A brain stimulation approach is explored to help people with Parkinson’s find things more easily in their surroundings by improving how they visually search and scan the environment.

  NIH research Louis Stokes Cleveland VA Medical Center · Cleveland, United States · NIH-11300391

• New imaging to map tiny brain wiring near deep brain stimulation targets

  This project builds a label-free, high-resolution imaging system to map microscopic brain wiring around areas used for deep brain stimulation, aiming to help people with movement and psychiatric disorders.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11284034

• Personalized adaptive deep brain stimulation for Parkinson's disease

  This project is creating DBS that automatically adjusts stimulation using brain signals and movement markers to help people with Parkinson's get better symptom control.

  NIH research Duke University · Durham, United States · NIH-11264820

• Improving deep brain stimulation for Parkinson's disease using advanced imaging techniques

  This study is looking to make deep brain stimulation for Parkinson's disease even better by using new imaging technology to help doctors find the right spot in the brain during surgery, which could lead to improved results for patients.

  NIH research Duke University · Durham, United States · NIH-11264350

• Thalamic Coordinated Reset Deep Brain Stimulation for Essential Tremor

  A new brain stimulation approach is being tested to help people with essential tremor by using coordinated, lower-intensity stimulation to the thalamus.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11263676

• MRI and AI to personalize deep brain stimulation for Parkinson's

  This project uses brain MRI and artificial intelligence to help personalize deep brain stimulation settings so people with Parkinson's get faster, safer symptom relief.

  NIH research Ge Medical Systems Information Technologies, INC · Niskayuna, United States · NIH-11263609

• Improving personalized deep brain stimulation models using brain recordings

  This work uses each person's brain images and electrical recordings to build better computer models that predict how deep brain stimulation affects brain circuits in Parkinson's disease and related conditions.

  NIH research Emory University · Atlanta, United States · NIH-11249623

• Deep brain stimulation targeting the medial forebrain bundle for severe treatment‑resistant depression

  This project will use deep brain stimulation of a key brain pathway to help people whose depression hasn't improved with other treatments.

  NIH research Feinstein Institute for Medical Research · Manhasset, United States · NIH-11239120

• Deep brain stimulation in the motor thalamus to help muscle control after stroke

  This research uses targeted deep brain stimulation in the motor thalamus to strengthen brain-to-muscle signals for people with lasting weakness after stroke.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11235829

• New deep brain stimulation technique for treating essential tremor

  This study is testing a new way to use deep brain stimulation to help people with essential tremor by using a gentler method that aims to reduce side effects, so you can feel better without as many complications.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11223028

Related topics

Quick answers

How many Deep Brain Stimulation clinical trials are recruiting right now?

30, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (13 trials), China (6 trials), Netherlands (4 trials), Turkey (Türkiye) (2 trials), Germany (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1, Early Phase 1: 1, Phase 2/3: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →