Condition

Parkinson's Disease (PD) clinical trials and research

• 55Clinical trials
• 2NIH research projects
• 3New in 30 days
• 20Countries

Newest Parkinson's Disease (PD) clinical trials

All recruiting trials (55)

• Automated language analysis to help diagnose neurodegenerative diseases

  A multilingual AI-powered language test is being tried to see if speech and language patterns can help differentiate Alzheimer’s, frontotemporal dementia, Lewy body dementia, and Parkinson’s from healthy aging.

  Recruiting Istituti Clinici Scientifici Maugeri SpA · Bari · NCT07906769

• Brain alpha-synuclein PET imaging in Parkinson's patients and healthy seniors

  This open-label study tests a radioactive tracer called [18F]MK-0947 to see how it behaves in the brains of people with Parkinson's disease compared with healthy elderly volunteers.

  Recruiting Phase 1 XingImaging, LLC · New Haven, Connecticut · NCT07880379

• Parkinson’s self-sufficiency and rehabilitation in a Czech spa setting

  This intervention tests whether a Czech self-sufficiency test can be used with people with Parkinson’s disease and sees how spa-based rehabilitation affects independence, cognition, balance, and walking.

  Recruiting Palacky University · Olomouc · NCT07872202

• Imaging PD progression with [18F]AV-133 using high- and standard-resolution PET

  This study tests how [18F]AV-133 PET imaging changes over 12 months in people with Parkinson's disease and a small group of healthy controls.

  Recruiting Phase 2 Michael J. Fox Foundation for Parkinson's Research · New Haven, Connecticut · NCT07830654

• Microelectrode-based brain stimulation for Parkinson’s and essential tremor

  This early feasibility test checks a new microelectrode-based brain stimulation method in adults with Parkinson’s disease or essential tremor who are already getting deep brain stimulation implants.

  Recruiting Lund University · Lund, Skåne County · NCT07820189

• Sleep and adaptive DBS in Parkinson’s disease

  This study tests whether adjusting adaptive deep brain stimulation during sleep can improve sleep quality and brain activity in people with Parkinson’s disease who already have DBS.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT07808346

• Biomarker Repository for Age-Related and Inherited Neurodegenerative Diseases

  This study collects blood and genetic samples from people with neurodegenerative diseases and their families to build a shared resource for studying disease risk and biology.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT07798700

• Early PD signals in people with REM sleep behavior disorder

  This study tests whether people with REM sleep behavior disorder show early signs of Parkinson’s disease before classic symptoms appear.

  Recruiting Danish Research Centre for Magnetic Resonance · Hvidovre · NCT07790744

• Left vs right subthalamic nucleus deep brain stimulation: how it changes thinking and mood in Parkinson’s

  This study tests whether turning DBS on the left or the right side of the brain changes cognition and mood in people with Parkinson’s disease.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT07777419

• STN-tTIS with Different Intervals Compared to Standard Parkinson’s Medicine

  This study tests whether different schedules of subthalamic nucleus-targeted transcranial temporal interference stimulation (STN-tTIS) can better improve motor symptoms in people with Parkinson’s disease than standard medications alone.

  Recruiting Ruijin Hospital · Shanghai, Shanghai Municipality · NCT07774312

• Music therapy for people with Parkinson's disease

  This study tests whether a personalized music therapy session using gentle string-playing, singing, and lyre can help reduce anxiety and improve quality of life for people with Parkinson's disease.

  Recruiting Klinik Arlesheim · Arlesheim, Basel-Landschaft · NCT07734181

• LSVT-LOUD therapy for Turkish-speaking people with Parkinson’s disease

  A Turkish-speaking group with Parkinson’s will try the LSVT-LOUD voice therapy to see if it improves loudness and speech quality.

  Recruiting Atlas University · Kâğıthane, Istanbul · NCT07730073

• Personalized music-guided walking for Parkinson’s disease

  A 3-month, self-directed walking program using a digital, music-based device is tested to see if it improves walking quality, everyday walking, and walking automaticity for people with Parkinson’s disease.

  Recruiting at 3 sites Boston University Charles River Campus · Boston, Massachusetts and 2 other locations · NCT07705373

• Directional PSA vs STN DBS for tremor-dominant PD

  This study tests whether directional DBS targeting the PSA or the STN helps people with tremor-dominant Parkinson’s disease, using a blinded crossover design.

  Recruiting Ruijin Hospital · Shanghai · NCT07700862

• Moving Yourself in Space and Time: MYSTIC

  This study tests a music-based stepping therapy to see if people with Parkinson's disease benefit from learning new steps and rhythms set to music.

  Recruiting Emory University · Atlanta, Georgia · NCT07697664

• Tele-rehab for Parkinson’s: twin-task upper‑extremity training at home vs. in clinic

  This trial tests whether tele-rehabilitation with synchronous or asynchronous dual-task upper-extremity training helps people with Parkinson’s compare to clinic-based dual-task training and standard single-task training.

  Recruiting Saglik Bilimleri Universitesi · Ankara · NCT07641556

• MTX325 in Parkinson’s Disease: a first-in-human dose study in adults

  This trial tests MTX325 versus placebo to see if it can help people with Parkinson’s disease, starting with healthy volunteers and extending to patients with mild to moderate PD.

  Recruiting at 9 sites Phase 1 Mission Therapeutics · Adelaide and 17 other locations · NCT07630545

• STN-targeted non-invasive brain stimulation for Parkinson’s symptoms

  A non-invasive procedure called tTIS is tested in people with Parkinson’s to see if it helps motor and non-motor symptoms.

  Recruiting Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine · Shanghai, Shanghai Municipality · NCT07625540

• Psilocybin Therapy for Depression in Parkinson’s Disease

  This study tests whether psilocybin therapy can help reduce depressive symptoms in people with Parkinson’s disease.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT07610369

• How EMST helps swallowing in Parkinson's patients

  This study tests whether four weeks of expiratory muscle strength training can improve swallowing in people with Parkinson’s-related dysphagia.

  Recruiting University Hospital Muenster · Münster · NCT07606547

• SST001 PET tracer safety and pharmacokinetics in healthy adults and people with PD or MSA

  This study tests SST001, a PET tracer, to see if it is safe and how it behaves in the body for healthy adults and people with Parkinson’s disease or multiple system atrophy.

  Recruiting at 2 sites Phase 1 Synusight Biotech (Shanghai) Co., Ltd. · Wuxi, Jiangsu and 1 other locations · NCT07604116

• Closed-loop TMS to reduce tremor

  This trial tries phase-locked transcranial magnetic stimulation (TMS) to reduce tremor in people with essential tremor or Parkinson's disease.

  Recruiting University of Oxford · Oxford, Oxfordshire · NCT07574164

• How hip abductor muscle control relates to balance and walking in aging and Parkinson's disease

  This project will test whether hip abductor muscle strength and steadiness affect balance and walking in healthy adults of different ages and people with Parkinson's disease.

  Recruiting at 2 sites Chang Gung Memorial Hospital · Taoyuan and 1 other locations · NCT07568951

• Wearable exoskeleton to support walking and balance in older adults and people with Parkinson's

  This project will test whether a wearable robotic exoskeleton can help older adults and people with Parkinson's walk steadier, improve balance, and reduce effort.

  Recruiting Centre intégré de santé et de services sociaux de l'Outaouais · Gatineau, Quebec · NCT07567482

• Comparing cervical versus thoracic trans‑spinal magnetic stimulation added to brain TMS to improve walking in Parkinson's disease

  This trial will test whether adding cervical or thoracic trans‑spinal magnetic stimulation to repetitive brain TMS helps people with Parkinson's and gait problems walk better and move more easily.

  Recruiting Universidade Federal de Pernambuco · Recife, Pernambuco · NCT07488026

• Using subcortical brain signals to guide DBS contact selection for Parkinson's

  It will test whether local field potential (LFP) recordings can help pick the best deep brain stimulation contact for people with Parkinson's disease during routine hospital visits.

  Recruiting University Hospital of Leuven Leuven · Leuven, Vlaams-Brabant · NCT07485621

• Phygital exergames to improve hand and arm function in Parkinson's

  This pilot will see if adding real physical objects to exergames helps people with early Parkinson's improve hand and arm function during a 12-week program.

  Recruiting University of Health Sciences Lahore · Lahore, Punjab Province · NCT07475741

• Remote Haptic Rehab for Parkinson's Disease

  This trial tests a remote, hands-on rehabilitation system to help adults with Parkinson's disease improve motor function at home.

  Recruiting Virginia Polytechnic Institute and State University · Blacksburg, Virginia · NCT07457710

• How deep brain stimulation affects learning and producing speech in Parkinson's disease and essential tremor

  This research will see if turning deep brain stimulation on and off changes how adults with Parkinson's disease or essential tremor learn and produce new speech sound sequences.

  Recruiting at 2 sites Boston University Charles River Campus · Boston, Massachusetts and 1 other locations · NCT07455760

• Ear-based vagus nerve stimulation to boost decision-making and other thinking skills in people with Parkinson's and healthy adults

  This project will try gentle electrical stimulation of the ear (taVNS) to see if it improves decision-making and other thinking skills in people with Parkinson's disease and in healthy adults.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT07424365

• Low-intensity focused ultrasound for movement and seizure disorders

  This trial will try low-intensity focused ultrasound (LIFUS) to see if it can safely change brain activity in people with movement disorders or epilepsy.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07417280

• Measuring Hsp90 levels in the human brain

  This trial tests whether a PET tracer called [11C]HSP990 can measure Hsp90 levels in the brains of healthy adults and people with Parkinson's disease, Alzheimer's disease, or ALS.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven, Vlaam-Brabant · NCT07380204

• Shanghai clinical cohort for Parkinson's disease and multiple system atrophy (Reserve)

  This project will try to use clinical exams, brain scans, electrical tests, genetic and biosample data from people with Parkinson's disease or multiple system atrophy to find early markers and better subtypes.

  Recruiting Ruijin Hospital · Shanghai · NCT07353463

• Brain-signal guided DBS programming for Parkinson's

  This study will test whether using brain signals recorded from your Percept DBS device (beta power or a broad-band algorithm) can pick stimulation settings that work as well or better than standard clinician programming for people with Parkinson's.

  Recruiting University of Florida · Gainesville, Florida · NCT07348705

• Using patient-reported ratings to guide DBS programming

  This project tests whether combining patients' own ratings with brain signal recordings can help find better DBS settings for people with Parkinson's who already have STN-DBS implants.

  Recruiting Ludwig-Maximilians - University of Munich · München · NCT07336199

• SUL-238 effects on brain energy (31P‑MRS) in early, untreated Parkinson's disease

  This study will test whether taking SUL-238 for 28 days improves brain mitochondrial energy markers in people with early, untreated Parkinson's disease, using 31P‑MRS scans and a placebo comparison.

  Recruiting Phase 2 GEN İlaç ve Sağlık Ürünleri A.Ş. · Groningen · NCT07322887

• Atomoxetine to reduce freezing of gait in Parkinson's disease by targeting the brain's noradrenaline system

  This trial will test whether the medication atomoxetine can reduce how often or how severely people with Parkinson's disease experience freezing of gait.

  Recruiting Phase 3 Radboud University Medical Center · Nijmegen, Gelderland · NCT07316296

• Checking the safety of the oral drug VT-5006 in adults with and without Parkinson's disease

  This will test whether taking an oral medicine called VT-5006 is safe and tolerable for healthy adults and for adults with Parkinson's disease.

  Recruiting Phase 1 Vertero Therapeutics · Leiden · NCT07310264

• Online Acceptance and Commitment Therapy to support people with young-onset Parkinson's disease

  This project will test whether an eight-week online group Acceptance and Commitment Therapy (ACT) program can help adults aged 21-65 with young-onset Parkinson's disease improve psychological flexibility and quality of life.

  Recruiting University of Coimbra · Coimbra · NCT07310147

• Biological causes and brain compensation of swallowing problems in Parkinson's disease

  This study will test whether specific biological markers and brain activity patterns explain and help compensate for swallowing problems in people with Parkinson's disease.

  Recruiting Heinrich-Heine University, Duesseldorf · Düsseldorf, North Rhine-Westphalia · NCT07299448

• Buntanetap for people with Parkinson's disease

  This 36-month open-label trial will try buntanetap 30 mg once daily in people with Parkinson's disease, including those with deep brain stimulation or who previously received buntanetap, to see if it is safe long-term.

  Recruiting at 28 sites Phase 2/3 Annovis Bio Inc. · Birmingham, Alabama and 28 other locations · NCT07284784

• Non-invasive retinal imaging for early diagnosis of Parkinson's disease

  This project will test whether a quick, non-invasive eye (fundus) scan can spot early Parkinson's disease in people aged 40–80, including those with early PD, atypical parkinsonism, essential tremor, and healthy volunteers.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07244640

• Vagus nerve stimulation to improve ankle muscle activity and posture in Parkinson's disease

  This project will test whether non-invasive vagus nerve stimulation at the neck can improve ankle muscle activation, walking, and balance in people with Parkinson's disease.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07226284

• Diet-driven approach to ease constipation in people with Parkinson’s

  A dietitian-guided nutritional plan is tested to see if it increases weekly bowel movements and improves gut health in adults with Parkinson’s disease and functional constipation.

  Recruiting Hospital de Clinicas de Porto Alegre · Porto Alegre, Rio Grande do Sul · NCT07213856

• Edmond J. Safra Parkinson's multi-arm, multi-stage treatment platform

  This project tests whether adding telmisartan or terazosin (versus placebo) helps people with Parkinson's disease who are already taking Parkinson's medications.

  Recruiting at 2 sites Phase 3 University College, London · London and 1 other locations · NCT07207057

• Changes in a gut bacterial gene (csgA) in people with Parkinson's disease

  This project tests whether a gut bacterial gene called csgA is present or differs in people with Parkinson's disease who have gastrointestinal symptoms.

  Recruiting Vertero Therapeutics · Leiden · NCT07175922

• Combined febuxostat and inosine treatment for people with early Parkinson's

  We will test whether taking febuxostat plus inosine twice daily for 12 weeks is safe for adults with early-stage Parkinson's disease.

  Recruiting Phase 1 Fujita Health University · Toyoake, Aichi-ken · NCT07170475

• Increase brain and blood glutathione with gamma‑glutamylcysteine in early Parkinson's

  This will test whether daily gamma‑glutamylcysteine supplements raise brain and blood glutathione and improve motor, thinking, and gut symptoms in people with early Parkinson's.

  Recruiting Phase 1 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07064005

• Brain imaging to map a newly discovered motor-control network in Parkinson's disease.

  Using MRI, researchers will see if a newly discovered brain network called the Somato-Cognitive Action Network (SCAN) is altered in people with Parkinson's disease.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT07024875

• Using brain stimulation to reduce tremors in Parkinson's disease

  This study is testing a new brain stimulation technique to see if it can help reduce hand tremors in people with Parkinson's disease.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg, Free and Hanseatic City of Hamburg · NCT06993571

• Bemdaneprocel for motor symptoms in adults with Parkinson's disease

  This Phase 3 study will test whether bemdaneprocel, a dopaminergic cell therapy, can improve motor symptoms in adults aged 45–75 with Parkinson's disease compared with sham surgery.

  Recruiting at 43 sites Phase 3 BlueRock Therapeutics · Scottsdale, Arizona and 42 other locations · NCT06944522

• Testing a new PET tracer for measuring brain protein in neurodegenerative diseases

  This study is testing a new imaging tool to see if it can help detect a specific brain protein in people with conditions like Parkinson's Disease and Dementia.

  Recruiting Early Phase 1 AC Immune SA · Solna · NCT06891703

• Using brain stimulation to improve movement and reduce fatigue in Parkinson's disease

  This study is testing if a type of brain stimulation can help people with Parkinson's disease move better and feel less tired.

  Recruiting Sanford Health · Fargo, North Dakota · NCT06883266

• Acupuncture and Moxibustion for Motor Symptoms in Early Parkinson's Disease

  This study is testing a special acupuncture method to see if it can help improve movement problems in people with early Parkinson's Disease.

  Recruiting Guang'anmen Hospital of China Academy of Chinese Medical Sciences · Beijing, Beijing Municipality · NCT06874803

• Comprehensive assessment of neurodegeneration and dementia

  This project will collect brain scans, cognitive tests, and biological samples over time to see how dementia and related conditions progress in adults aged 50–90, including people with Parkinson's and people without cognitive problems.

  Recruiting at 11 sites McGill University · Calgary, Alberta and 18 other locations · NCT03402919

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Using brain-computer signals to detect color-vision changes linked to Parkinson's

  This project uses a noninvasive brain-computer interface test to find color-vision changes that could signal Parkinson’s disease in people with or at risk for PD.

  NIH research Albany Research Institute, INC. · Albany, United States · NIH-11326723

• Using brain-computer interfaces to identify color vision issues in Parkinson's disease patients

  This study is looking at how special technology can help find color vision problems in people with Parkinson's disease, making it easier to spot these issues early and improve care for patients.

  NIH research Albany Research Institute, INC. · Albany, United States · NIH-11162312

Related topics

Quick answers

How many Parkinson's Disease (PD) clinical trials are recruiting right now?

55, as of November 12, 2026. 3 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 20 countries. The most sites are in United States (17 trials), China (7 trials), Germany (5 trials), Netherlands (4 trials), Canada (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 6, Phase 2: 3, Phase 3: 3, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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