Using advanced MRI to improve deep brain stimulation for essential tremor
The STEREO-DBS Study: 7-Tesla MRI Brain Network Analysis for Deep Brain Stimulation in Essential Tremor
This study is testing if using advanced MRI technology can help doctors place deep brain stimulation electrodes better for people with essential tremor, aiming to improve their movement and quality of life.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Academic / other |
| Locations | 1 site (Amsterdam, North Holland) |
| Trial ID | NCT05909839 on ClinicalTrials.gov |
What this trial studies
This study aims to enhance the effectiveness of deep brain stimulation (DBS) for patients with essential tremor by utilizing 7-Tesla MRI technology. The approach focuses on visualizing brain networks connected to the thalamus, which is crucial for DBS electrode placement. By creating detailed structural connectivity maps, the study seeks to individualize DBS settings, potentially leading to better patient outcomes and fewer side effects. The primary goal is to determine if this advanced imaging technique can improve motor symptoms and overall quality of life for patients undergoing DBS.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old with idiopathic essential tremor who have undergone deep brain stimulation.
Not a fit: Patients who are legally incompetent or unable to provide written informed consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective and personalized treatment options for patients with essential tremor.
How similar studies have performed: Other studies have shown promise in using advanced MRI techniques for DBS, suggesting that this approach could be a meaningful advancement in treatment.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \> 18 years * Idiopathic essential tremor who underwent DBS Exclusion Criteria: * Legally incompetent adults * No written informed consent
Where this trial is running
Amsterdam, North Holland
- Amsterdam UMC, location AMC — Amsterdam, North Holland, Netherlands (Recruiting)
Study contacts
- Study coordinator: Maarten Bot, MD, PhD
- Email: m.bot@amsterdamumc.nl
- Phone: 0031621514048
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.