Understanding brain activity related to speech in neurological diseases
Cortical-Basal Ganglia Speech Networks
This study is trying to see how brain activity affects speaking in people with neurological disorders like Parkinson's disease and dystonia who are about to have deep brain stimulation surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | Massachusetts General Hospital Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Trial ID | NCT04286308 on ClinicalTrials.gov |
What this trial studies
This research focuses on how brain activity affects speech perception and production in individuals with neurological disorders like Parkinson's disease and dystonia. The study will utilize a novel experimental approach and various analytic techniques to investigate the role of neural activity in cortical-basal ganglia circuits during speech production. Participants will be individuals scheduled for deep brain stimulation surgery, allowing researchers to collect electrophysiological data to better understand these processes.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-85 with a definitive diagnosis of Parkinson's disease, essential tremor, or dystonia who are scheduled for deep brain stimulation surgery.
Not a fit: Patients with hearing loss or those who do not speak English may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatments for speech disorders associated with neurological diseases.
How similar studies have performed: While this approach is innovative, similar studies have shown promise in understanding neural mechanisms in speech production.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Subjects scheduled for DBS implantation, as determined by the clinical multidisciplinary movement disorders board with definitive diagnosis of Parkinson's disease, essential tremor or dystonia. 2. Subjects able to provide informed consent and comply with task instructions. 3. Subjects 18-85 years old Exclusion Criteria: 1. Subjects with reported hearing loss. 2. Non-English-speaking subjects
Where this trial is running
Boston, Massachusetts
- Massachusetts General Hospital — Boston, Massachusetts, United States (Recruiting)
Study contacts
- Study coordinator: Mark Richardson, MD, PhD
- Email: mark.richardson@mgh.harvard.edu
- Phone: 617-726-8849
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.