Test to flag essential tremor patients at risk of Parkinson’s progression by detecting phosphorylated alpha-synuclein
Official title: Analysis of Cutaneous Phosphorylated alpha-Synuclein to Identify Patients at Risk of Progressing from Essential Tremor to Parkinson's Disease
Funded at Cnd Life Sciences, INC. · NIH-11401181 · Data updated 2026-11-12
A new test being developed for people with essential tremor to see who might later develop Parkinson’s disease.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cnd Life Sciences, INC. NIH-funded |
| Lab location | 1 site (Scottsdale, UNITED STATES) |
| Project start | September 5, 2025 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,012,800 |
| NIH project number | 5R44NS143486-02 |
| Project ID | NIH-11401181 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults diagnosed with essential tremor who are at risk of developing Parkinson’s disease and are candidates for biomarker testing.
✕Less likely to help
Patients without essential tremor or those not at risk for phenoconversion may not benefit from this test.
What this research studies
This project aims to create and validate a biomarker test that looks for phosphorylated alpha-synuclein in patients with essential tremor to predict if and when they may develop Parkinson’s disease. It uses direct-to-phase II SBIR funding to advance test development and evaluate predictive capability. If successful, the test could help doctors tailor monitoring and treatment plans for those at higher risk.
Why it matters
Potential benefit: If successful, patients with essential tremor could receive earlier guidance and closer monitoring for Parkinson's progression.
How similar studies have gone: Prior studies show phosphorylated alpha-synuclein is associated with Parkinson’s features, but a clinically practical predictive test for ET patients is still being developed.
Where this research is happening
-
Cnd Life Sciences, INC.
Scottsdale, United States Active
Researchers
- Principal investigator: Gibbons, Christopher H — Cnd Life Sciences, INC.
- Study coordinator: Gibbons, Christopher H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.