Condition

Central Nervous System Diseases clinical trials and research

• 29Clinical trials
• 1NIH research projects
• 1New in 30 days
• 18Countries

Newest Central Nervous System Diseases clinical trials

All recruiting trials (29)

• Registering medical data and care outcomes for ALS, SMA, and other motor disorders

  This registry slowly collects routine-care information from adults with ALS, SMA, or other motor disorders to see how they’re treated and how care affects outcomes.

  Recruiting Ambulanzpartner Soziotechnologie APST GmbH · Berlin, State of Berlin · NCT07900672

• Selective activation of the adrenomedullin receptor to provoke migraine in adults with migraine without aura

  This study tests whether selectively activating the adrenomedullin receptor can trigger migraine attacks in adults who have migraine without aura, after blocking CGRP receptors.

  Recruiting Danish Headache Center · Glostrup Municipality · NCT07451769

• Silevertinib plus temozolomide for newly diagnosed GBM with unmethylated MGMT and EGFRvIII

  This trial tests whether adding silevertinib to standard temozolomide helps people with newly diagnosed glioblastoma that have EGFRvIII and an unmethylated MGMT promoter live longer without the cancer getting worse.

  Recruiting at 38 sites Phase 2 Black Diamond Therapeutics, Inc. · Birmingham, Alabama and 37 other locations · NCT07326566

• Increasing daily physical activity to slow cognitive decline in alpha-synuclein disorders

  This study will test whether using a motivational smartphone app to increase everyday physical activity can help slow cognitive decline in people aged 50–80 with isolated REM sleep behavior disorder (an early sign of alpha‑synuclein disease).

  Recruiting University Hospital, Bonn · Bonn, North Rhine West-Falia · NCT07324330

• Virtual reality plus bilateral brain stimulation to improve arm and hand recovery after stroke

  We will try combining virtual reality exercises with bilateral transcranial direct current stimulation (bi‑tDCS) to improve arm and hand movement in adults at least three months after a unilateral stroke.

  Recruiting King Saud University · Riyadh · NCT07288385

• Slow-SPEED: Can a smartphone app help people with prodromal Parkinson's stay more active?

  This trial tests whether a remote smartphone app can help people with a LRRK2 G2019S or GBA1 N370S mutation increase daily activity and see if exercise might slow prodromal Parkinson's signs.

  Recruiting Radboud University Medical Center · Rochester, New York and 1 other locations · NCT06993142

• Heart assessment to check repeat-stroke risk in people with atrial fibrillation

  This project will test whether detailed heart examinations can find which people with atrial fibrillation who just had an ischemic stroke are at high risk of having another stroke.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT06954610

• Portable EEG to triage suspected stroke patients in ambulances

  This trial will test whether a portable dry‑electrode EEG headset (StrokePointer) can detect large vessel occlusion strokes in adults with suspected acute stroke so ambulance crews can take them directly to hospitals that perform thrombectomy.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, North Holland · NCT06871969

• Evaluating therapy for patients with minor strokes and large vessel occlusion

  This study is testing different treatment options for patients with minor strokes caused by blocked large blood vessels to see which ones help them recover better.

  Recruiting Sir Run Run Shaw Hospital · Hangzhou, Zhejiang · NCT06633809

• Video call assessment for suspected stroke

  This study tests if using video calls between neurologists and emergency responders can help quickly and accurately assess patients who might be having a stroke.

  Recruiting University of Southern Denmark · Aabenraa, Region Syddanmark · NCT06570681

• Using PET/MRI to Monitor Brain Inflammation

  This study is testing how PET/MRI scans can help track brain inflammation in people with conditions like stroke, autoimmune encephalitis, and multiple sclerosis.

  Recruiting Tongji Hospital · Wuhan, Hubei · NCT06467773

• Evaluating the impact of artery calcification on stroke treatment outcomes

  This study is trying to see if the amount of calcium in the arteries affects how well stroke patients do after a specific treatment for blocked blood vessels.

  Recruiting Zhujiang Hospital · Guangzhou, Guangdong · NCT06418698

• Using deep brain stimulation to improve speech and arm function after stroke

  This study is testing if deep brain stimulation can help improve hand movement and speech in people who have had a stroke.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06303869

• Increasing physical activity in patients at risk of Parkinson's disease using a smartphone app

  This study is testing a smartphone app to help people at risk of Parkinson's disease increase their physical activity and exercise intensity over two years.

  Recruiting Radboud University Medical Center · Nijmegen, Gelderland · NCT06193252

• Monitoring brain-derived tau levels in acute ischemic stroke patients

  This study is testing how brain-derived tau levels change in stroke patients over 48 hours to see if it can help understand their condition and improve treatment decisions.

  Recruiting Ludwig-Maximilians - University of Munich · Munich, Bavaria · NCT06121336

• Evaluating a new treatment for cognitive function in mild Alzheimer's dementia

  This study is testing a new treatment that combines brain stimulation and cognitive training to see if it can help people with mild Alzheimer's dementia improve their thinking skills.

  Recruiting at 11 sites Advanced Technology & Communications · Incheon, Bupyeong 6(yuk)-dong, Bupyeong-gu and 10 other locations · NCT06088121

• Using virtual reality to help stroke patients walk again

  This study tests whether using virtual reality during walking rehab can help stroke patients who can't walk feel more motivated and improve their walking ability compared to regular rehab methods.

  Recruiting University Hospital, Limoges · Limoges · NCT06053619

• Comparing awake and asleep deep brain stimulation for essential tremor

  This study is testing whether deep brain stimulation done while patients are awake works better than when it's done while they're asleep for people with essential tremor who haven't found relief with medication.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, North Holland · NCT05968976

• Using virtual and mixed reality technology with mirror therapy for stroke rehabilitation

  This study is testing new virtual and mixed reality therapies combined with mirror therapy to see if they can help stroke patients recover their movement better than traditional methods.

  Recruiting Chang Gung Memorial Hospital · Taoyuan City · NCT05903235

• Intra-arterial tenecteplase given after thrombectomy for anterior large-vessel ischemic stroke with no-reflow or residual clot

  This trial will test whether giving tenecteplase directly into the artery at the end of thrombectomy helps people with anterior large-vessel ischemic stroke treated within 24 hours of symptom onset.

  Recruiting at 11 sites Phase 2/3 University of Melbourne · Gold Coast, Queensland and 11 other locations · NCT05892510

• Multi-domain lifestyle intervention for older adults at risk of cognitive decline in China

  This study is testing a lifestyle program that includes exercise, healthy eating, brain training, and managing health risks to see if it can help older adults in China avoid memory problems and dementia.

  Recruiting Zhejiang University · Hangzhou, Zhejiang · NCT05886114

• Transcutaneous spinal stimulation to improve blood pressure after a recent spinal cord injury

  We will try a noninvasive spinal stimulation to see if it raises and steadies blood pressure in people 7–30 days after a thoracic spinal cord injury who have low blood pressure or dizziness when sitting up.

  Recruiting Kessler Foundation · West Orange, New Jersey · NCT05731986

• Transcutaneous spinal stimulation to stabilize blood pressure after spinal cord injury

  This will test whether noninvasive transcutaneous spinal cord stimulation can raise and stabilize blood pressure in people with chronic high-level spinal cord injuries who experience orthostatic hypotension.

  Recruiting Kessler Foundation · West Orange, New Jersey · NCT05725499

• Combination treatment for brain metastasis from ER+/HER-2- breast cancer

  This study is testing a new combination treatment of elacestrant and abemaciclib to see if it can help people with brain metastases from estrogen receptor-positive, HER-2 negative breast cancer.

  Recruiting at 78 sites Phase 1/2 Stemline Therapeutics, Inc. · Fullerton, California and 85 other locations · NCT05386108

• Analyzing Inflammatory Biomarkers for Diagnosing CNS Autoimmune Diseases

  This study is testing if certain markers in blood and spinal fluid can help doctors more accurately diagnose multiple sclerosis and other similar brain conditions.

  Recruiting Centre Hospitalier Universitaire de Nice · Nice · NCT05056740

• Combining testosterone therapy with walking training to improve health after spinal cord injury

  This study is testing if combining testosterone therapy with walking training can help men with spinal cord injuries who have low testosterone and trouble walking improve their health and mobility.

  Recruiting at 2 sites Phase 2 North Florida Foundation for Research and Education · Gainesville, Florida and 1 other locations · NCT04460872

• Exploring Brain Connections for Arm Movement After Stroke

  This study is testing how different parts of the brain work together to control arm movement before and after a stroke, to see if new stimulation methods can help stroke patients regain better use of their arms.

  Recruiting VA Office of Research and Development · Pittsburgh, Pennsylvania · NCT04286516

• Using a virus therapy to treat recurrent cerebellar brain tumors in children

  This study is testing a new virus treatment for children with recurring brain tumors to see if it can help them get better when combined with a low dose of radiation.

  Recruiting at 3 sites Phase 1 M.D. Anderson Cancer Center · Birmingham, Alabama and 2 other locations · NCT03911388

• A smartphone app to help manage depression symptoms

  This study is testing a smartphone app that helps people with depression track their symptoms and treatment to see if it can improve their care.

  Recruiting Centre Hospitalier Charles Perrens, Bordeaux · Bordeaux · NCT03678194

NIH-funded research (1)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Exploring tiny RNAs as potential markers for brain diseases linked to gammaherpesvirus.

  This study is looking at tiny pieces of genetic material linked to the Epstein-Barr virus to see if they can help doctors diagnose brain-related issues in people with weakened immune systems, and patients may be asked to share samples to help with this research.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-10839906

Related topics

Quick answers

How many Central Nervous System Diseases clinical trials are recruiting right now?

29, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 18 countries. The most sites are in United States (9 trials), France (4 trials), Germany (4 trials), China (4 trials), Netherlands (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 2/3: 1, Phase 1/2: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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