Evaluating deep brain stimulation for essential tremor

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial aims to compare the effects of deep brain stimulation (DBS) against the best medical treatment for patients with essential tremor (ET) in a randomized, single-blinded controlled format. It will assess the efficacy of DBS targeting both the ventrolateral thalamus and a new target in the posterior subthalamic area. The study also seeks to map the optimal target areas for stimulation and evaluate the long-term effects of DBS on ET. By refining the approach to DBS, the trial hopes to improve outcomes for patients suffering from this condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of ET, as decided by the movement disorder specialist; Substantial incapacity; Duration of symptoms \> 5 years; Age 18 - 75; unsatisfying effect from β-blockers, or be unable to tolerate the medical therapy.

Exclusion Criteria:

* Cognitive impairment; Co-morbidity or non-compliance likely to jeopardize the result or to confuse the evaluation; Normal surgical exclusion criteria.

Where it's running

• Linköping University Hospital
  Linköping, Sweden Recruiting
• Lund University Hospital
  Lund, Sweden Recruiting
• Karolinska University Hospital
  Stockholm, Sweden Recruiting
• Umeå University Hospital
  Umeå, Sweden Recruiting
• Akademiska Sjukhuset
  Uppsala, Sweden Recruiting
• Sahlgrenska University Hospital
  Gothenburg, Sweden Not yet recruiting

Study contacts

• Principal investigator: Anders Fytagoridis, PhD — Karolinska Institutet
• Study coordinator: Anne-Louice Eriksson
• Email: annelouice.eriksson@vll.se
• Phone: +468907850000

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Encora X1 in Daily Life for Essential Tremor

  This real-world study tests how the Encora X1 wrist device affects day-to-day activities for adults with essential tremor over three years.

  Recruiting Encora, Inc. · Boston, Massachusetts · NCT07911488

• Intraoperative Microelectrode Recordings with MAVEN vs Standard Equipment

  This study tests whether MAVEN can match the recording data collected during DBS surgery for movement disorders using standard equipment.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07868614

• Microelectrode-based brain stimulation for Parkinson’s and essential tremor

  This early feasibility test checks a new microelectrode-based brain stimulation method in adults with Parkinson’s disease or essential tremor who are already getting deep brain stimulation implants.

  Recruiting Lund University · Lund, Skåne County · NCT07820189

• Non-Invasive Nerve Stimulation for Essential Tremor: Long-Term Safety and Effectiveness

  This study tests whether a non-invasive stimulation device called TAPS helps reduce tremor in adults with essential tremor over a long period.

  Recruiting Ruijin Hospital · Shanghai · NCT07774598

• Low Intensity Focused Ultrasound for Essential Tremor in Adults

  This early-stage, open-label study tests whether repeated low-intensity focused ultrasound can safely and briefly modulate tremor in people with essential tremor.

  Recruiting Early Phase 1 University of California, Los Angeles · Los Angeles, California · NCT07599592

• Closed-loop TMS to reduce tremor

  This trial tries phase-locked transcranial magnetic stimulation (TMS) to reduce tremor in people with essential tremor or Parkinson's disease.

  Recruiting University of Oxford · Oxford, Oxfordshire · NCT07574164

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.