Temporal interference deep brain stimulation for essential tremor

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center, prospective study testing temporal interference (TI), a noninvasive method that produces overlapping electric fields to focus stimulation in deep brain nuclei. Eligible participants aged 30–70 with action and postural tremor will receive TI stimulation with clinical and imaging data collected before and after treatment. Clinical scores and imaging will be analyzed to measure changes in tremor severity and brain response. The goal is to determine whether TI can serve as a feasible noninvasive alternative to invasive deep brain stimulation for essential tremor.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 30-70 years old, regardless of gender. Action tremor and postural tremor in both upper limbs, or action tremor and postural tremor in one limb;
* No history of mental diseases;
* Informed consent signed.

Exclusion Criteria:

* Presence of other neurological diseases affecting the study (such as epilepsy);
* Patients with moderate to severe cognitive impairment (Montreal Cognitive Assessment ≤ 18 points);
* Orthopedic diseases that may affect motor symptoms;
* Patients taking antipsychotic or antidepressant medications;
* Presence of metal implants in the body (such as brain pacemakers or cardiac pacemakers);
* History of electroconvulsive therapy;
* Presence of cardiovascular risk factors, etc.

Where it's running

• Xuanwu Hospital, Capital Medical University
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Liankun Ren, MD — Xuanwu Hospital, Beijing
• Study coordinator: Liankun Ren, MD
• Email: renlk2022@outlook.com
• Phone: +86 13681576621

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Microelectrode-based brain stimulation for Parkinson’s and essential tremor

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• Non-Invasive Nerve Stimulation for Essential Tremor: Long-Term Safety and Effectiveness

  This study tests whether a non-invasive stimulation device called TAPS helps reduce tremor in adults with essential tremor over a long period.

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• Low Intensity Focused Ultrasound for Essential Tremor in Adults

  This early-stage, open-label study tests whether repeated low-intensity focused ultrasound can safely and briefly modulate tremor in people with essential tremor.

  Recruiting Early Phase 1 University of California, Los Angeles · Los Angeles, California · NCT07599592

• Closed-loop TMS to reduce tremor

  This trial tries phase-locked transcranial magnetic stimulation (TMS) to reduce tremor in people with essential tremor or Parkinson's disease.

  Recruiting University of Oxford · Oxford, Oxfordshire · NCT07574164

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.