Deep brain stimulation for movement disorders like Parkinson's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of deep brain stimulation (DBS) surgery on patients with movement disorders such as Parkinson's disease, essential tremor, and dystonia. It aims to collect data on brain and nerve cell function during the surgery while providing standard care treatment. Patients aged 18 and older who have not responded well to other treatments will be screened for eligibility and may undergo DBS to alleviate their symptoms. The study will utilize pre- and post-operative imaging and intra-operative recordings to assess the effectiveness of the procedure.

Why it matters

Who can join: the full rules

* INCLUSION CRITERIA:

To be eligible for entry into the study, candidates must meet all the following criteria:

Be 18 years of age or older.

Able to provide informed consent.

Have a clinical diagnosis of one of the following as confirmed by the NIH movement disorders clinic team and the multi-disciplinary DBS surgical conference, and deemed as appropriate for the use of Deep Brain Stimulation therapy:

* idiopathic PD not adequately controlled with medication or
* primary dystonia that is medically refractory, or
* ET that is not adequately controlled by medications or constitutes a significant functional disability.

EXCLUSION CRITERIA:

Candidates will be excluded if they:

Are unable or unwilling to give informed consent to the research procedures.

Where it's running

• National Institutes of Health Clinical Center
  Bethesda, Maryland, United States Recruiting

Study contacts

• Principal investigator: Kareem A Zaghloul, M.D. — National Institute of Neurological Disorders and Stroke (NINDS)
• Study coordinator: Sharon C Park
• Email: sharon.park@nih.gov
• Phone: (301) 496-2921

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Intraoperative Microelectrode Recordings with MAVEN vs Standard Equipment

  This study tests whether MAVEN can match the recording data collected during DBS surgery for movement disorders using standard equipment.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07868614

• Investigating the relationship between genetic mutations and brain changes in dystonia

  This study is trying to see how genetic changes linked to dystonia affect the brain in people with the condition compared to healthy individuals.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT03428009

• Development of a brain atlas for improved treatment of neurological conditions

  This study is trying to create a detailed brain map to help doctors find the best treatment spots for patients with conditions like Parkinson's, OCD, and epilepsy.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT00575081

• Low-intensity focused ultrasound for movement and seizure disorders

  This trial will try low-intensity focused ultrasound (LIFUS) to see if it can safely change brain activity in people with movement disorders or epilepsy.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07417280

• Outcomes of radiofrequency ablation for movement disorders

  This study looks at how well a specific treatment called radiofrequency ablation works for people with movement disorders like Parkinson's disease and essential tremor.

  Recruiting at 4 sites Boston Scientific Corporation · Cologne and 3 other locations · NCT06553625

• Validation of a deep learning platform for diagnosing isolated dystonia

  This study is testing a new deep learning tool to see if it can help doctors diagnose isolated dystonia more accurately and quickly.

  Recruiting Massachusetts Eye and Ear Infirmary · Boston, Massachusetts · NCT05317390

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.