Image-guided programming for deep brain stimulation in dystonia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the feasibility of using image-guided programming for pallidal deep brain stimulation (DBS) in patients with dystonia. Dystonia is characterized by involuntary muscle contractions, and while DBS is an established treatment, outcomes can be unpredictable, with a significant number of patients not responding to therapy. The researchers have developed a computer model to predict optimal stimulation settings based on data from previously treated patients, which may improve treatment outcomes. The study will involve a randomized, double-blind crossover design to assess the effectiveness of this new programming approach.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Chronic deep brain stimulation (\> 1 year) in the internal globus pallidus in patients with isolated dystonia.
* Deep brain stimulation settings and dystonia medication stable for \> 3 months.
* Understanding about and consent to the study and signed informed consent form.

Exclusion Criteria:

* Relevant comorbidities that might interfere with study endpoints (esp. palliative disease and severe neurologic or psychiatric comorbidities).

Where it's running

• Department of Neurology, University Hospital Würzburg
  Würzburg, Bavaria, Germany Recruiting

Study contacts

• Principal investigator: Martin Reich — Department of Neurology - University Hosiptal Würzburg
• Study coordinator: Martin Reich, Dr.
• Email: Reich_M1@ukw.de
• Phone: 0931-201-0

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Investigating the relationship between genetic mutations and brain changes in dystonia

  This study is trying to see how genetic changes linked to dystonia affect the brain in people with the condition compared to healthy individuals.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT03428009

• Low-intensity focused ultrasound for movement and seizure disorders

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• Measuring brain network activity to predict and improve outcomes in children with dystonia

  This project will test whether noninvasive brain and muscle recordings, and comparing DBS on versus off, can predict and help improve motor outcomes for children with dystonia.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT07325175

• Registry for pediatric deep brain stimulation outcomes

  This study is creating a database to collect information on how deep brain stimulation helps children with movement disorders like dystonia and Tourette syndrome, to see how safe and effective the treatment is.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT06585618

• Deep brain stimulation therapy for sleep issues in Parkinson's disease

  This study is testing if deep brain stimulation can help people with Parkinson's disease improve their sleep problems.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05962489

• Intraoperative Microelectrode Recordings with MAVEN vs Standard Equipment

  This study tests whether MAVEN can match the recording data collected during DBS surgery for movement disorders using standard equipment.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07868614

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.