Mediterranean diet for managing weight and body composition after bilateral subthalamic nucleus deep brain stimulation in Parkinson's disease
Official title: Investigation of the Effect of the Mediterranean Diet on Nutritional Status in Parkinson's Patients Undergoing Bilateral Subthalamic Nucleus Deep Brain Stimulation
Run by Ankara University · NCT07187739 · Data updated 2026-11-12
It will see if following a Mediterranean diet for three months after bilateral subthalamic nucleus deep brain stimulation helps adults with Parkinson's control weight and improve body composition.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 45 Years to 64 Years |
| Sex | All |
| Enrollment | 24 (estimated) |
| Sponsor | Ankara University Academic / other |
| Locations | 1 site (Ankara, Ankara) |
| Status | Recruiting |
| Started | September 25, 2025 |
| Main results expected | March 2026 |
| Study ends | March 2026 |
| Registry record updated | December 3, 2025 |
| Trial ID | NCT07187739 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 45–64 with Parkinson's disease scheduled for or having undergone bilateral STN DBS who have MMSE ≥24 and can follow dietary guidance while continuing antiparkinsonian therapy.
✕Probably not a fit
Patients with psychiatric illness, cognitive impairment (MMSE <24), or medical conditions requiring a special diet are unlikely to benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized interventional trial will assign adults with Parkinson's disease undergoing bilateral subthalamic nucleus DBS to either Mediterranean diet guidance for three months or to continue their usual diet. Researchers will measure body weight, body composition, nutritional status, appetite, quality of life, and physical activity before and after the intervention. Eligible participants are 45–64 years old, have a Mini Mental State Examination score ≥24, and continue their antiparkinsonian medications. The trial is conducted at Ankara Etlik City Hospital and focuses on post-surgical dietary management to limit weight gain commonly seen after DBS.
Why it matters
Potential benefit: If successful, the Mediterranean diet could reduce post-DBS weight gain and improve body composition, appetite, nutritional status, and overall quality of life.
How similar studies have gone: The Mediterranean diet has documented metabolic and general health benefits and has been associated with better outcomes in some Parkinson's cohorts, but using it specifically to prevent weight gain after STN DBS is relatively novel and not well established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Being between 45-64 years of age * Signing informed consent * Undergoing STN DBS surgery * Continuing antiparkinsonian therapy * Those with a Mini Mental Test result of ≥24 points Exclusion Criteria: * Having any psychiatric illness * Those with a Mini Mental Test result of \<24 points * Those with a disease requiring a special diet other than Parkinson's Disease
Where it's running
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Ankara Etlik City Hospital
Ankara, Ankara, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Nursena ERSOY SÖKE, MsC
- Email: ersoynursena73@gmail.com
- Phone: (+90) 534 330 11 11
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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How physical activity might help people with Parkinson’s disease who have DBS-STN implants
This study tests whether adding regular physical activity can help people with Parkinson’s who have DBS-STN stimulation by trying a structured physiotherapy approach alongside standard care.
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Patterned deep brain stimulation delivered at home for Parkinson's
This study will test whether three types of patterned deep brain stimulation can be used safely and comfortably at home in people with Parkinson's who already have stable bilateral STN or GPi Boston Scientific DBS systems.
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Frequency-specific stimulation of subthalamic nucleus subregions to improve inhibitory control in Parkinson's disease
This tests whether stimulating different parts of the subthalamic nucleus at low (5 Hz) or high (130 Hz) frequencies can improve inhibitory control in people with Parkinson's disease who have deep brain stimulation.
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How deep brain stimulation affects thinking and memory in Parkinson's
This project will use MRI scans to see if subthalamic nucleus deep brain stimulation (DBS) changes brain networks and relates to thinking or memory declines in people with Parkinson's disease who already have DBS implants.
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Advanced brain imaging for improving deep brain stimulation in Parkinson's and essential tremor patients
This study is testing if advanced brain imaging can help doctors place and program deep brain stimulation better for people with Parkinson's disease and essential tremor to improve their movement.
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Adaptive versus continuous subthalamic nucleus deep brain stimulation for people with Parkinson's
This project will try adaptive DBS versus regular continuous DBS in people with Parkinson's who already have Medtronic Percept STN implants to see if one gives more daily ON time without troublesome dyskinesia over six months.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.